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Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats

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Abstract

Objective

This study was conducted to evaluate the effect of p-Coumaric acid, a common dietary phenol, on monosodium urate crystal-induced inflammation in rats—an experimental model for acute gouty arthritis.

Methods

Paw edema, levels/activities of lysosomal enzymes, lipid peroxidation, enzymic antioxidants and a histopathological examination of ankle joints were evaluated in control and monosodium urate crystal-induced inflamed rats. Further, an acetic acid-induced writhing test and tail immersion test were employed to screen for analgesic effects, yeast-induced pyrexia was used to test for antipyretic effects, and gastric ulceration was used to evaluate ulcerogenic effects.

Results

A significant increase in paw edema, lysosomal enzyme activity and lipid peroxidation levels was observed in monosodium urate crystal-induced rats, whereas activities of enzymic antioxidants were found to be decreased when compared to control rats. Nevertheless, treatment with p-Coumaric acid (100 mg/kg b.wt) significantly reverted the altered physical and biochemical parameters back to near normal levels, as evidenced by the histopathology of the ankle joints. In addition, p-Coumaric acid also exhibited potent analgesic and antipyretic effects devoid of any adverse impact on gastric mucosa.

Conclusion

The results of this study reveal the potential anti-inflammatory effect of p-Coumaric acid against monosodium urate crystal-induced inflammation in rats.

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The authors have declared no conflicts of interests.

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Authors and Affiliations

  1. Immunopathology Lab, School of Bio Sciences and Technology, VIT University, Vellore, 632 014, Tamil Nadu, India

    Samuel Joshua Pragasam & MahaboobKhan Rasool

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  1. Samuel Joshua Pragasam
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  2. MahaboobKhan Rasool
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Correspondence to MahaboobKhan Rasool.

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Responsible Editor: Jerauld Skotnicki.

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Pragasam, S.J., Rasool, M. Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats. Inflamm. Res. 62, 489–498 (2013). https://doi.org/10.1007/s00011-013-0602-7

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  • DOI: https://doi.org/10.1007/s00011-013-0602-7

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