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Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide

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Abstract

Introduction

The mast cell is an immunocyte, but its functions in the brain remain unclear.

Materials and methods

In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.

Conclusion

We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.

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Fig. 1

References

  1. Dropp JJ. Mast cells in mammalian brain. Acta Anat. 1976;94:1–21.

    Article  PubMed  CAS  Google Scholar 

  2. Silverman AJ, Sutherland AK, Wilhelm M, Silver R. Mast cells migrate from blood to brain. J Neurosci. 2000;20:401–8.

    PubMed  CAS  Google Scholar 

  3. Nautiyal KM, McKellar H, Silverman AJ, Silver R. Mast cells are necessary for the hypothermic response to LPS-induced sepsis. Am J Physiol-Regul Integr Comp Physiol. 2009;296:595–602.

    Article  Google Scholar 

  4. Kovács P, Hernádi I, Wilhelm M. Mast cells modulate maintained neuronal activity in the thalamus in vivo. J Neuroimmunol. 2006;171:1–7.

    Article  PubMed  Google Scholar 

  5. Dubayle D, Servière J, Menétrey D. Evidence for serotonin influencing the thalamic infiltration of mast cells in rat. J Neuroimmunol. 2005;159:20–30.

    Article  PubMed  CAS  Google Scholar 

  6. Biran V, Cochois V, Karroubi A, Arrang JM, Charriaut-Marlangue C, Héron A. Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain. Brain Pathol. 2008;18:1–9.

    Article  PubMed  CAS  Google Scholar 

  7. Lindsberg PJ, Strbian D, Karjalainen-Lindsberg ML. Mast cells as early responders in the regulation of acute blood-brain-barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab. 2010;30:689–702.

    Article  PubMed  Google Scholar 

  8. Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. Mast cells and inflammation. Biochim Biophys Acta. 1822;2012:21–33.

    Google Scholar 

  9. Dubayle D, Servière J, Menétrey D. The effects of viscero-somatic interactions on thalamic mast cell recruitment in cystitic rats. J Neuroimmunol. 2007;190:18–27.

    Article  PubMed  CAS  Google Scholar 

  10. Turrin NP, Gayle D, Ilyin SE, Flynn MC, Langhans W, Schwartz GJ, Plata-Salamán CR. Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intra-peritoneal administration of bacterial lipopolysaccharide. Brain Res Bull. 2001;54:443–53.

    Article  PubMed  CAS  Google Scholar 

  11. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd ed. Sydney: Academic Press; 1986.

    Google Scholar 

  12. Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H. Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol. 2001;167:2250–6.

    PubMed  CAS  Google Scholar 

  13. Moreno B, Jukes JP, Vergara-Irigaray N, Errea O, Villoslada P, Perry VH, Newman TA. Systemic inflammation induces axon injury during brain inflammation. Ann Neurol. 2011;70:932–42.

    Article  PubMed  CAS  Google Scholar 

  14. Gaboury JP, Niu XF, Kubes P. Nitric oxide inhibits numerous features of mast cell-induced inflammation. Circulation. 1996;93:318–26.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Neurophysics and Physiology, CNRS UMR 8119, Paris Descartes University, 45 Rue Des Saints Pères, 75270, Paris, France

    David Dubayle

  2. Experimental, Metabolic and Clinical Biology Department, Faculty of Phamaceutical Sciences, Paris Descartes University, 4 Avenue de L’Observatoire, 75270, Paris, France

    Anne Héron

Authors
  1. David Dubayle
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  2. Anne Héron
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Corresponding author

Correspondence to Anne Héron.

Additional information

Responsible Editor: Andras Falus.

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Dubayle, D., Héron, A. Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide. Inflamm. Res. 61, 1295–1297 (2012). https://doi.org/10.1007/s00011-012-0565-0

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  • DOI: https://doi.org/10.1007/s00011-012-0565-0

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