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Helicobacter pylori: a ROS-inducing bacterial species in the stomach

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Abstract

Background

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been reported to impact gastric inflammation and carcinogenesis. However, the precise mechanism by which Helicobacter pylori induces gastric carcinogenesis is presently unclear.

Aim

This review focuses on H. pylori-induced ROS/RNS production in the host stomach, and its relationship with gastric carcinogenesis.

Results

Activated neutrophils are the main source of ROS/RNS production in the H. pylori-infected stomach, but H. pylori itself also produces ROS. In addition, extensive recent studies have revealed that H. pylori-induced ROS production in gastric epithelial cells might affect gastric epithelial cell signal transduction, resulting in gastric carcinogenesis. Excessive ROS/RNS production in the stomach can damage DNA in gastric epithelial cells, implying its involvement in gastric carcinogenesis.

Conclusion

Understanding the molecular mechanism behind H. pylori-induced ROS, and its involvement in gastric carcinogenesis, is important for developing new strategies for gastric cancer chemoprevention.

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research (B) to T.Y. (no. 21390184) and (C) to Y.N. (no.22590705) from Japan Society for the Promotion of Science, by a City Area Program to T.Y. and Y.N. from Ministry of Education, Culture, Sports, Science and Technology, Japan, and by an Adaptable and Seamless Technology Transfer Program through target-driven R&D to Y.N. from Japan Science and Technology Agency.

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  1. Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kajiicho, Kawaramachidori Hirokouji Agaru, Kamigyou-ku, Kyoto, 602-8566, Japan

    Osamu Handa, Yuji Naito & Toshikazu Yoshikawa

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  1. Osamu Handa
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  2. Yuji Naito
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  3. Toshikazu Yoshikawa
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Correspondence to Osamu Handa.

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Responsible Editor: Kumar Visvanathan.

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Handa, O., Naito, Y. & Yoshikawa, T. Helicobacter pylori: a ROS-inducing bacterial species in the stomach. Inflamm. Res. 59, 997–1003 (2010). https://doi.org/10.1007/s00011-010-0245-x

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