Abstract.
Objectives:
To describe the concentrations of sTREM-1 in patients with sepsis and to explore the effects of their serum on the expression of TREM-1 on U937 monocytes.
Methods:
Blood was sampled at regular time intervals in 56 patients with sepsis. Concentrations of tumour necrosis factor-alpha (TNFα), interleukin-1beta (IL-1α), IL-6, IL-8, IL-10 and IL-12p70 and sTREM-1 were measured. U937 monocytes were incubated in the presence of serum at sepsis onset.
Results:
Median sTREM-1 concentration on day 1 for patients with septic shock was 915 pg/ml and 228.5 pg/ml for those without shock (p = 0.002). TNFα, IL-1α, IL-6, IL-8 and IL-10 did not differ between them. A positive correlation was found between changes of sTREM-1 and SOFA scores from day 1 to 7. Sera of patients with septic shock evoked a significant increase of the expression of TREM-1. The concentrations of TNFα and IL-8 in supernatants increased only after stimulating with sera of patients without shock, but not after stimulating with sera of patients with shock.
Conclusions:
Levels of sTREM-1 correlated with sepsis severity. sTREM-1 is considerably higher in patients with shock compared to patients without shock. The serum of shocked patients could stimulate the expression of TREM-1 on U937 monocytes.
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Received 5 March 2007; returned for revision 4 June 2007; received from final revision 26 February 2008; accepted by K. Visvanathan 21 May 2008
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Dimopoulou, I., Orfanos, S.E., Pelekanou, A. et al. Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes. Inflamm. Res. 58, 127–132 (2009). https://doi.org/10.1007/s00011-008-7039-4
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DOI: https://doi.org/10.1007/s00011-008-7039-4