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Microvesicles in Health and Disease

  • Review
  • Published:
Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of MVs in terms of intercellular communication and ensuant signal transduction, including the transport of proteins (unconventional protein export) as well as of mRNA and microRNA. MVs also have roles in membrane repair, the removal of misfolded proteins, and in the control of apoptosis. We also discuss the role MVs have been shown to have in invasive growth and metastasis as well as in hypoxia in tumours and cerebral ischaemia. The association of MVs in infectious and autoimmune disease is also summarised together with their possible use as therapeutic agents.

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Acknowledgments

We thank M. McCrossan (London School of Hygiene and Tropical Medicine) for help with obtaining the electron microscopy images.

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Authors and Affiliations

  1. Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK

    Jameel M. Inal, Ephraim A. Ansa-Addo, Dan Stratton, Sharad Kholia, Samuel S. Antwi-Baffour & Samireh Jorfi

  2. Perinatal Brain Repair Group, Institute for Women’s Health, University College London, London, UK

    Sigrun Lange

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  1. Jameel M. Inal
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  2. Ephraim A. Ansa-Addo
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  3. Dan Stratton
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  4. Sharad Kholia
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  5. Samuel S. Antwi-Baffour
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  6. Samireh Jorfi
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  7. Sigrun Lange
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Correspondence to Jameel M. Inal.

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E. A. Ansa-Addo and D. Stratton contributed equally to this work.

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Inal, J.M., Ansa-Addo, E.A., Stratton, D. et al. Microvesicles in Health and Disease. Arch. Immunol. Ther. Exp. 60, 107–121 (2012). https://doi.org/10.1007/s00005-012-0165-2

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  • DOI: https://doi.org/10.1007/s00005-012-0165-2

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