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Protein Kinase C Isoforms in Neutrophil Adhesion and Activation

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Neutrophils are the first line of defense against bacterial and mycotic pathogens. In order to reach the pathogens, neutrophils need to transmigrate through the vascular endothelium and migrate to the site of infection. Defense strategies against pathogens include phagocytosis, production and release of oxygen radicals through the oxidative burst, and degranulation of antimicrobial and inflammatory molecules. Protein kinase C (PKC)-δ is required for full assembly of NADPH oxidase and activation of the respiratory burst. Neutrophils also express PKC-α and -β, which may be involved in adhesion, degranulation and phagocytosis, but the evidence is not conclusive yet. This review focuses on the potential impact of protein kinase C isoforms on neutrophil adhesion and activation.

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Abbreviations

BPI:

Bactericidal permeability increasing protein

CXCL:

CXC ligand

DAG:

Diacylglycerol

ERM:

Ezrin/radixin/moesin

fMLP:

Formyl-methionyl-leucyl-phenylalanine

GEF:

Guanine nucleotide exchange factor

GPCR:

G-protein coupled receptor

ICAM:

Intercellular adhesion molecule

IL:

Interleukin

LFA-1:

Lymphocyte function-related antigen-1

Mac-1:

Macrophage receptor-1

MAPK:

Mitogen-activated protein kinase

PKC:

Protein kinase C

PLC:

Phospholipase C

PMA:

Phorbol 12-myristate 13-acetate

PI3K:

Phosphoinositide 3-kinase

PS:

Phosphatidylserine

PSGL-1:

P-selectin glycoprotein ligand-1

TNF-α:

Tumor necrosis factor-α

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  1. Department of Nephrology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Anna Bertram

  2. Division of Inflammation Biology, La Jolla Institute for Allergy and Inflammation, 9420 Athena Circle, La Jolla, CA, 92037, USA

    Klaus Ley

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  1. Anna Bertram
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  2. Klaus Ley
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Bertram, A., Ley, K. Protein Kinase C Isoforms in Neutrophil Adhesion and Activation. Arch. Immunol. Ther. Exp. 59, 79–87 (2011). https://doi.org/10.1007/s00005-011-0112-7

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