Skip to main content
SpringerLink
Log in

Topical tretinoin 0.1% for pregnancy-related abdominal striae: An open-label, multicenter, prospective study

  • Published:
Advances in Therapy Aims and scope Submit manuscript

Abstract

In an open-label, multicenter, prospective study, 20 women applied tretinoin (retinoic acid) cream 0.1% daily for 3 months to pregnancy-related stretch marks in the abdominal area. Efficacy was evaluated by analysis of one preselected target lesion, which was rated on a six-point scale (−1 = worse to 4 = cleared). At week 12, significant global improvement was noted from baseline in all stretch marks, and the target lesion decreased in length by 20% (P = .01). Erythema and scaling, the most common adverse events, occurred in 11 patients, decreased in severity after the first month of treatment, and were controlled with continued application of tretinoin and petroleum jelly ointment. In this small study, topical application of tretinoin significantly improved the clinical appearance of pregnancy-related stretch marks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Madlon-Kay DJ. Striae gravidarum: folklore and fact.Arch Fam Med. 1993;2:507–511.

    Article  PubMed  CAS  Google Scholar 

  2. Erickson CV, Matus NR. Skin disorders of pregnancy.Am Fam Physician. 1994;9:605–610.

    Google Scholar 

  3. Hanno R, Saleeby ER, Krull EA. Disorders of pregnancy. In: Dermis DJ, ed.Clinical Dermatology. Philadelphia: Lippincott; 1991:1–5.

    Google Scholar 

  4. Shuster S. The cause of striae distensae.Acta Derm Venereol. 1979;59(suppl 85):161–169.

    CAS  Google Scholar 

  5. Pribanich S, Simpson FG, Yarbrough CL, White S. Low-dose tretinoin does not improve striae distensae: a double-blind, placebo-controlled study.Cutis. 1994;54:121–124.

    PubMed  CAS  Google Scholar 

  6. Hecker H. New treatments for stretch marks.Am Baby. 1997;59:6.

    Google Scholar 

  7. Levin W. Striae gravidarum: folklore and fact.Arch Fam Med. 1995;4:98. Letter.

    Article  PubMed  CAS  Google Scholar 

  8. Elson ML. Treatment of striae distensae with topical tretinoin.J Dermatol Surg Oncol. 1990;16: 267–270.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gynecological-Obstetrics Clinic, ISSEMYM Hospital, Mexico City, Mexico

    Onésimo Rangel M.D.

  2. Mexico City, Mexico

    Isabel Arias M.D. & Edith García M.D.

  3. León, Gto, Mexico

    Sergio Lopez-Padilla M.D.

Authors
  1. Onésimo Rangel M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Isabel Arias M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Edith García M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sergio Lopez-Padilla M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rangel, O., Arias, I., García, E. et al. Topical tretinoin 0.1% for pregnancy-related abdominal striae: An open-label, multicenter, prospective study. Adv Therapy 18, 181–186 (2001). https://doi.org/10.1007/BF02850112

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02850112

Keywords

Search

Navigation