Human cornea: Superior and central oxygen demands

Abstract

Corneal oxygen demands, expressed as ratios of uptake rate relative to baseline rates derived from unstressed corneas, were determined with a micropolarographic system for central (closed eye) and superior (open eye) locations of one cornea of each of seven human subjects. The closed-eye central corneal measurements were repeated during two additional experimental sessions. Intrasubject variability of the three mean closed-eye central corneal rate ratios ranged as high as 23%, possibly representing effects of homeostatic mechanisms on the palpebral conjunctival capillaries of some subjects. For the open-eye superior cornea, which was covered by the upper eyelid of every subject prior to measurement, oxygen demand was found to have a greater intersubject range, but was diminished in magnitude relative to the demand associated with the closed-eye central cornea. Superior corneal oxygen demand was not found to be predictable from closed-eye central corneal oxygen demand or extent of eyelid overlap onto the cornea and thus indicated localized open-eye superior corneal environments that were significantly different from those of the corresponding closed-eye central corneas. Such localized environments may be critically important when gauging the susceptibility of particular eyes to superior corneal pathology during contact lens wear.