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The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein

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Summary

In this study, we show that HPV-16 E5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevation. In addition, Ras-dependent pathway, as well as PKC-dependent pathway, leads to HPV-16 E5-induced c-jun gene expression.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, Republic of China

    S. -L. Chen, C. -H. Huang, T. -C. Tsai & Y. -P. Tsao

  2. Department of Microbiology, Soochow University, Taipei, Taiwan, Republic of China

    K. -Y. Lu

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  1. S. -L. Chen
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  2. C. -H. Huang
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  3. T. -C. Tsai
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  4. K. -Y. Lu
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  5. Y. -P. Tsao
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Chen, S.L., Huang, C.H., Tsai, T.C. et al. The regulation mechanism of c-jun and junB by human papillomavirus type 16 E5 oncoprotein. Archives of Virology 141, 791–800 (1996). https://doi.org/10.1007/BF01718155

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  • DOI: https://doi.org/10.1007/BF01718155

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