Summary
The roles of the four genes of the prn gene cluster involved in L-proline catabolism in Aspergillus nidulans have been investigated. prnD and prnC encode, respectively, proline exidase and ΔI-pyrroline-5-carboxylate (P5C) dehydrogenase. prnB is almost certainly the structural gene for the proline-inducible major proline permease. The prnA product has no structural role in these activities but is a positive acting regulatory molecule necessary for the expression of prnD, prnC and, to a lesser extent, prnB. Evidence favouring de novo synthesis of P5C dehydrogenase upon induction in the presence of a functional prnA allele is also presented.
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Jones, S.A., Arst, H.N. & MacDonald, D.W. Gene roles in the prn cluster of Aspergillus nidulans . Curr Genet 3, 49–56 (1981). https://doi.org/10.1007/BF00419580
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DOI: https://doi.org/10.1007/BF00419580