Abstract
In order to evaluate the methionine uptake of a glioma with positron emission tomography (PET), the kinetics of carbon-11 methionine was investigated in 11 patients by measuring the free 11C-methionine in plasma as an input function following intravenous administration. When the mean clearance curve of free 11C-methionine in plasma instead of individual 11C-methionine clearance curves was used, mean differences in uptake rate and distribution volume were 4.0% and 4.6% respectively. By applying the mean clearance curve of free 11C-methionine in 18 glioma patients, significant differences in 11C-methionine uptake rate and distribution volume were found according to pathological grading. For the accurate evaluation of the metabolism of 11C-methionine, it is therefore preferable that the actual level of free 11C-methionine in the plasma be measured, especially for the follow-up of individual cases. The study also demonstrated that the mean clearance curve of 11C-methionine in plasma might be employed as an input curve for calculating the uptake rate and distribution volume with small errors.
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References
Aguilar TS, Benevenga NJ, Harper AE (1974) Effect of dietary methionine level on its metabolism in rats. J Nutr 104:761–771
Bergström M, Ericson K, Hagenfeldt L, Mosskin M, Holst H von, Narén G, Eriksson L, Ehrin E, Peter J (1987) PET study of methionine accumulation in glioma and normal brain tissue: competition with branched chain amino acids. J Comput Assist Tomogr 11:208–312
Bustany P, Chatel M, Derlon JM, Sgouropoulos P, Soussaline F, Syrota A (1986) Brain tumor protein synthesis and histological grades: a study by positron emission tomography with C-11-l-methionine. J Neurooncol 3:397–404
Derlon JM, Bourdet C, Bustany P, Chatel M, Therson J, Darcel F, Syrota A (1989) [11C]L-methionine uptake in gliomas. Neurosurgery 25:720–728
Ericson K, Bromqvist G, Bergström M, Eriksson L, Stone-Elander S (1987) Application of a kinetic model on the methionine accumulation in intracranial tumors studied with positron emission tomography. Acta Radiol 28:505–509
Hatazawa J, Ishiwata K, Itoh M, Kameyama M, Kubota K, Ido T, Matsuzawa T, Yoshimoto T, Watanuki S, Seo S (1989) Quantitative evaluation of l-[methyl-C11]methionine uptake in tumor using positron emission tomography. J Nucl Med 30:1809–1813
Hoshino T, Rodriguez LA, Cho KG, Lee KS, Wilson CB, Edwards MSB, Levin VA, Davis AR (1988) Prognostic implications of the proliferative potential of low-grade astrocytoma. J Neurosurg 69:839–842
Ishiwata K, Vaalburg W, Elsinga PH, Paans AMJ, Woldring MG (1988) Comparison of l-[1-11C]methionine and l-methyl-[11C]methionine for measuring in vivo protein synthesis rate with PET. J Nucl Med 29:1419–1427
Ishiwata K, Hatazawa J, Kubota K, Kameyama M, Itch M, Matsuzawa T, Takahashi T, Iwata R, Ido T (1989) Metabolic fate of l-[methyl-11C]methionine in human plasma. Eur J Nucl Med 15:665–669
Kameyama M, Shirane R, Itoh J, Sato K, Katakura R, Yoshimoto T, Hatazawa J, Itoh M, Ido T (1990) The accumulation of 11C-methionine and histological grade in cerebral glioma patients studied with PET. Acta Neurochir 104:8–12
Lija A, Bergström K, Hartvig P, Spännare B, Halldin C, Lundqvist H, Långström B (1985) Dynamic study of supratentorial gliomas with l-methyl-11C-methionine and positron emission tomography. AJNR 6:505–514
Lundqvist H, Stålnacke CG, Langström B, Jones B (1985) Labeled metabolites in plasma after intravenous administration of [11CH3]-l-methionine. In: The metabolism of the human brain studied with positron emission tomography. Raven, New York, pp 233–240
Mosskin M, Holst H, Bergström M, Collins VP, Eriksson L, Johnström, Norén G (1987) Positron emission tomography with 11C-methionine and computed tomography of intracranial tumors compared with histopathologic examination of multiple biopsies. Acta Radiol 28:673–681
Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple time uptake data. J Cereb Blood Flow Metab 3:1–7
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Sato, K., Kameyama, M., Ishiwata, K. et al. Dynamic study of methionine uptake in glioma using positron emission tomography. Eur J Nucl Med 19, 426–430 (1992). https://doi.org/10.1007/BF00177369
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DOI: https://doi.org/10.1007/BF00177369