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Design, solvent-free synthesis and antibacterial activity evaluation of new coumarin sulfonamides

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Abstract

A simple cost-effective and green method was presented for the synthesis of coumarin bis sulfonamides. Seventeen novel coumarin sulfonamides were synthesized in good to high yield and purity in six steps starting from 2-amino thiazole, aniline, and 4-methoxy aniline. All of the reactions have been done under green conditions without using any hazardous solvent. The chemical structures of the products were elucidated by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. Also, the anti-bacterial properties of the synthesized sulfonamides were investigated using two strains of Staphylococcus (gram-positive) and Escherichia coli (gram-negative) bacteria.

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Acknowledgements

Financial support of this study was provided by Islamic Azad University of Shahreza.

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Authors and Affiliations

  1. Department of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, Shahreza, Isfahan, Iran

    Farzaneh Aminarshad, Shima Heidari & Ahmad Reza Massah

  2. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Neda Mostajeran

  3. Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Neda Mostajeran

  4. Razi Chemistry Research Center, Islamic Azad University Shahreza Branch, Shahreza, Isfahan, Iran

    Ahmad Reza Massah

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  1. Farzaneh Aminarshad
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Aminarshad, F., Heidari, S., Mostajeran, N. et al. Design, solvent-free synthesis and antibacterial activity evaluation of new coumarin sulfonamides. J IRAN CHEM SOC 19, 547–562 (2022). https://doi.org/10.1007/s13738-021-02344-3

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  • DOI: https://doi.org/10.1007/s13738-021-02344-3

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