Abstract
The aim of the present work was to investigate the swelling behavior and the in vitro release of acemetacin and bovine serum albumin from alginate gel beads crosslinked with Ca2+ or Ba2+. The release profiles suggested that the extent of swelling of the alginate beads played an important role in the release of drug. Small drugs are mainly released via diffusion through the alginate gel matrix. Compared with small drugs, large molecule drugs are difficult to diffuse through the pores of the matrix bead until the beads swell to a certain extent to provide enough large pores. The Ba2+ crosslinked alginate beads showed slower release rate compared with the Ca2+ crosslinked alginate beads, whether loaded the large molecules or small drugs. In conclusion, the Ba2+ crosslinked alginate beads are considered more suitable than Ca2+ crosslinked alginate beads for using as a sustained release vehicle especially for large molecule drugs.
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References
Das S, Ng KY. Colon-specific Delivery of Resveratrol: Optimization of Multi-particulate Calcium-pectinate Carrier [J]. Int. J. Pharm., 2010,385(1–2):20–28
Kim TH, Park YH, Kim KJ, et al. Release of Albumin from Chitosancoated Pectin Beads in vitro [J]. Int. J. Pharm., 2003,250(2):371–383
Al-Musa S, Abu FD, Badwan AA. Evaluation of Parameters Involved in Preparation and Release of Drug Loaded in Crosslinked Matrices of Alginate [J]. J. Control. Release, 1999,57(3):223–232
Kikuchi A, Kawabuchi M, Watanabe A, et al. Effect of Ca2+-alginate Gel Dissolution on Release of Dextran with Different Molecular Weights [J]. J. Control. Release, 1999,58(1):21–28
Wee S, Gombotz WR. Protein Release from Alginate Matrices [J]. Adv. Drug Deliv. Rev., 1998,31(3):267–285
Witschi C, Mrsny RJ. In vitro Evaluation of Microparticles and Polymer Gels for Use as Nasal Platforms for Protein Delivery [J]. Pharm. Res., 1999,16(3):382–390
Vandenberg GW, De La Noue J. Evaluation of Protein Release from Chitosan-alginate Microcapsules Produced Using External or Internal Gelation [J]. J. Microencapsul., 2001,18(4):433–441
Vandenberg GW, Drolet C, Scott SL, et al. Factors Affecting Protein Release from Alginate-chitosan Coacervate Microcapsules During Production and Gastric/intestinal Simulation [J]. J. Control. Release, 2001,77(3):297–307
Mukai-Correa R, Prata AS, Alvim ID, et al. Controlled Release of Protein from Hydrocolloid Gel Microbeads Before and after Drying [J]. Curr. Drug Deliv., 2004,1(3):265–273
Zheng CH, Liang WQ, Li F, et al. Optimization and Characterization of Chitosan-coated Alginate Microcapsules Containing Albumin [J]. Pharmazie, 2005,60(6):434–438
Silva CM, Ribeiro AJ, Ferreira D, et al. Insulin Encapsulation in Reinforced Alginate Microspheres Prepared by Internal Gelation [J]. Eur. J. Pharm. Sci., 2006,29(2):148–159
Xu Y, Zhan C, Fan L, et al. Preparation of Dual Crosslinked Alginate-Chitosan Blend Gel Beads and in vitro Controlled Release in Oral Sitespecific Drug Delivery System [J]. Int. J. Pharm., 2007,336(2):329–337
Nagamori E, Honda H, Kobayashi T. Release of Embryogenic Carrot cells with High Regeneration Potency from Immobilized Alginate Beads [J]. J. Biosci. Bioeng., 1999,88(2):226–228
McLennan G, Johnson MS, Stookey KR, et al. Kinetics of Release of Heparin from Alginate Hydrogel [J]. J. Vasc. Interv. Radiol., 2000,11(8):1 087–1 094
Thorsen F, Read TA, Lund-Johansen M, et al. Alginate-encapsulated Producer Cells: A Potential New Approach for the Treatment of Malignant Brain Tumors [J]. Cell Transplant., 2000,9(6):773–783
Calafiore R, Luca G, Calvitti M, et al. Cellular Support Systems for Alginate Microcapsules Containing Islets, as Composite Bioartificial Pancreas [J]. Ann. N. Y. Acad. Sci., 2001,944:240–251
Klinkenberg G, Lystad KQ, TDW L, et al. Cell Release from Alginate Immobilized Lactococcus Lactis SSp. lactis in Chitosan and Alginate Coated Beads [J]. J. Dairy Sci., 2001,84(5):1 118–1 127
Pasparakis G, Bouropoulos N. Swelling Studies and in vitro Release of Verapamil from Calcium Alginate and Calcium Alginate-chitosan Beads [J]. Int. J. Pharm., 2006,323(1–2):34–42
Batycky RP, Hanes J, Langer R, et al. A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres [J]. J. Pharm. Sci., 1997,86(12):1 464–1 477
Sriamornsak P, Thirawong N, Puttipipatkhachorn S. Emulsion Gel Beads of Calcium Pectinate Capable of Floating on the Gastric Fluid: Effect of Some Additives, Hardening Agent or Coating on Release Behavior of Metronidazole[J]. Eur. J. Pharm. Sci., 2005,24(4):363–373
Morch YA, Donati I, Strand BL, et al. Effect of Ca2+, Ba2+, and Sr2+ on Alginate Microbeads [J]. Biomacromolecules, 2006,7(5):1 471–1 480
Castro GR, Chen J, Panilaitis B, et al. Emulsan-alginate Beads for Protein Adsorption [J]. J. Biomater. Sci. Polym. Ed., 2009,20(4):411–426
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Funded by the Chongqing Yuzhong District Science and Technology Project (No. 20100203), the Chongqing Municipal Education Commissionfunded project (No. KJ110323), the Chongqing Municipal Health Bureau Funded Project (2010-2-202) and the Chongqing Natural Science Foundation (No. CSTC, 2008BB5397)
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Yuan, P., Jia, Y., Zhang, L. et al. Swelling studies and in vitro release of acemetacin and BSA from alginate gel beads crosslinked with Ca2+ or Ba2+ . J. Wuhan Univ. Technol.-Mat. Sci. Edit. 27, 669–674 (2012). https://doi.org/10.1007/s11595-012-0526-z
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DOI: https://doi.org/10.1007/s11595-012-0526-z