Skip to main content

Advertisement

SpringerLink
Log in

Foveolar Choroidal Blood Flow in Idiopathic Macular Hole

  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose: To measure choroidal blood flow from foveal region in the eyes with idiopathic macular hole. Methods: Thirteen patients with macular hole and 20 age-matched healthy subjects were included into the study. While group 1 consisted of 13 eyes of idiopathic stage 4 macular hole, seven fellow eyes of the same patients with stage 1a macular hole formed the group 2. The control group (group 3) comprised the randomly selected eye of 20 age-matched healthy subjects. Mean values of blood perfusion parameters that were composed of volume, flow and velocity, were recorded from foveal region of fundus using Heidelberg Retinal Flowmeter (HRF). The differences between the three groups were compared with unpaired t-test, Wilcoxon Signed Rank and Fisher’s Exact test using statistical package program. Results: The mean blood volume and velocity in the eyes with stage 4 macular hole (group 1) and in the eyes with stage 1a macular hole (group 2) were both significantly lower than the eyes in control eyes (group 3) ( p < 0.05, unpaired t-test). Although, the mean blood “flow” parameter of group 2 was significantly lower than group 3 ( p < 0.05, unpaired t-test), there was no statistical difference in the “flow” parameter between group 1 and group 3 ( p > 0.05, unpaired t-test). The comparison between group 1 and group 2 revealed no significant difference in any perfusion parameter ( p > 0.05, Wilcoxon Signed Rank Test). Conclusion: Although, it may be result of macular hole, not necessarily the cause of it, these findings suggest that the eyes with idiopathic macular hole are associated with reduced foveolar blood flow. The measurement of the foveolar blood flow from choriocapillaris may be useful for identifying the subjects who have increased risk of development of macular hole in future. The study showed the association of a decrease in foveolar choroidal blood flow in eyes with idiopathic macular hole using HRF. Authors suggested that quantitative measurement of foveolar choroidal blood flow may be helpful for identifying the subjects who have increased risk of development of idiopathic macular hole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. InstitutionalAuthorNameThe Eye Disease Case–Control Study Group (1994) ArticleTitleRisk factors for idiopathic macular holes Am J Ophthalmol 118 754–776

    Google Scholar 

  2. CM Morgan H Schatz (1985) ArticleTitleIdiopathic macular holes Am J Ophthalmol 99 437–444 Occurrence Handle3985081

    PubMed  Google Scholar 

  3. RR Margherio CL Schepens (1972) ArticleTitleMacular breaks: 1. Diagnosis, etiology, and observations Am J Ophthalmol 74 219–232 Occurrence Handle4559896

    PubMed  Google Scholar 

  4. PJ Mc Donnell SL Fine AI Hillis (1982) ArticleTitleClinical features of idiopathic macular cyst and holes Am J Ophthalmol 93 777–786 Occurrence Handle7091263

    PubMed  Google Scholar 

  5. CM Morgan H Schatz (1986) ArticleTitleInvolutional macular thinning: a premacular hole condition Ophthalmology 93 153–161 Occurrence Handle3951821

    PubMed  Google Scholar 

  6. RD Allen J Brown H Zwick (2004) ArticleTitleLaser-induced macular holes demonstrate impaired choroidal perfusion Retina 24 92–97 Occurrence Handle10.1097/00006982-200402000-00013 Occurrence Handle15076949

    Article  PubMed  Google Scholar 

  7. G Michelson M Langhans MJM Groh (1995) ArticleTitleClinical investigation of the combination of a scanning laser ophthalmoscope and laser Doppler flowmeter Ger J Ophthalmol 4 342–349 Occurrence Handle8751099

    PubMed  Google Scholar 

  8. G Michelson B Schmauss MJ Langhans (1996) ArticleTitlePrinciple, validity, and reliability of Scanning Laser Doppler flowmetry J Glaucoma 5 99–105 Occurrence Handle8795741

    PubMed  Google Scholar 

  9. G Michelson B Schmauss (1995) ArticleTitleTwo dimensional mapping of the perfusion of the retina and optic nerve head Br J Ophthalmol 79 1126–1132 Occurrence Handle8562550

    PubMed  Google Scholar 

  10. R Bonner Nossal (1990) Principles of laser-Doppler flowmetry A Shepherd (Eds) Laser-Doppler Flowmetry Kluwer Boston 17–44

    Google Scholar 

  11. JD Gass (1988) ArticleTitleIdiopathic senile macular hole: its early stages and pathogenesis Arch Ophthalmol 106 629–639 Occurrence Handle3358729

    PubMed  Google Scholar 

  12. MH Rawji JG Flanagan (2001) ArticleTitleIntraocular and interocular symmetry in normal retinal capillary perfusion J Glaucoma 10 4–12 Occurrence Handle10.1097/00061198-200102000-00003 Occurrence Handle11219638

    Article  PubMed  Google Scholar 

  13. L Wang G Cull GA Cioffi (2001) ArticleTitleDepth of penetration of scanning laser doppler flowmetry in the primate optic nerve Arch Ophthalmol 119 1810–1814 Occurrence Handle11735792

    PubMed  Google Scholar 

  14. JD Gass (1995) ArticleTitleReappraisal of biomicroscopic classification of stages of development of a macular hole Am J Ophthalmol 119 752–759 Occurrence Handle7785690

    PubMed  Google Scholar 

  15. RN Johnson JDM Gass (1988) ArticleTitleIdiopathic macular holes: observations, stages of formation and implications for surgical intervention Ophthalmology 95 917–924 Occurrence Handle3174041

    PubMed  Google Scholar 

  16. NE Kelly RT Wendel (1991) ArticleTitleVitreous surgery for idiopathic macular holes: results of a pilot study Arch Ophthalmol 190 654–659

    Google Scholar 

  17. M Tsujikawa Y Sato JM Lewis Y Tano (1997) ArticleTitleSecondary vitrectomy for the treatment of macular holes occurring after vitrectomy Ophthalmic Surg Lasers 28 336–337 Occurrence Handle9101578

    PubMed  Google Scholar 

  18. WJ Lipham WE Smiddy (1997) ArticleTitleIdiopathic macular hole following vitrectomy; implications for pathogenesis Ophthalmic Surg Lasers 28 633–639 Occurrence Handle9268993

    PubMed  Google Scholar 

  19. Foos RY . Surface wrinkling retinopathy. In: Freeman HM, Hirose T, Schepens CL (Eds). Vitreous Surgery and Advances in Fundus Diagnosis and Treatment. New York, Appleton: 1977; 23–28.

  20. AM Roth RY Foos (1971) ArticleTitleSurface wrinkling retinopathy in eyes enucleated at autopsy Trans Am Acad Ophthalmol Otolaryngol 75 1047–1058 Occurrence Handle5097819

    PubMed  Google Scholar 

  21. DJ Apple (1981) Anatomy and histopathology of the macular region Rabb (Eds) Macular Disease Little Brown & Co. Boston 1–9

    Google Scholar 

  22. CE Riva SD Cranstoun JE Grunwald BL Petrig (1994) ArticleTitleChoroidal blood flow in the foveal region of the human ocular fundus Invest Ophthalmol Vis Sci 35 4273–4281 Occurrence Handle8002247

    PubMed  Google Scholar 

  23. JE Grunwald (1998) ArticleTitleFoveolar choroidal blood flow in age-related macular degeneration Invest Ophthalmol Vis Sci 39 385–390 Occurrence Handle9477998

    PubMed  Google Scholar 

  24. JE Grunwald SM Hariprasad J Dupont (1998) ArticleTitleEffect of aging on foveolar choroidal circulation Arch Ophthalmol 116 150–154 Occurrence Handle9488265

    PubMed  Google Scholar 

  25. A Bill G Sperber K Ujiie (1983) ArticleTitlePhysiology of the choroidal vascular bed Int Ophthalmol 6 101–107 Occurrence Handle10.1007/BF00127638 Occurrence Handle6403480

    Article  PubMed  Google Scholar 

  26. GA Croffi A Granstam A Alm (2003) Ocular circulation PL Kaufman A Alm (Eds) Adler’s Physiology of the Eye Mosby St Louis 747–784

    Google Scholar 

  27. JW Kiel WAJ ven Heuven (1995) ArticleTitleOcular perfusion pressure and choroidal blood flow in rabbit Invest Ophthalmol Vis Sci 36 579–585 Occurrence Handle7890489

    PubMed  Google Scholar 

  28. CE Riva P Titze M Hero BL Petrig (1997) ArticleTitleEffect of acute decreases of perfusion pressure on choroidal blood flow in humans Invest ophthalmol Vis Sci 38 1752–1760 Occurrence Handle9286263

    PubMed  Google Scholar 

  29. JV Lovasik H Kergoat CE Riva BL Petrig M Geiser (2003) ArticleTitleChoroidal blood flow during exercise-induced changes in the ocular perfusion pressure Invest Ophthalmol Vis Sci 44 2126–2132 Occurrence Handle10.1167/iovs.02-0825 Occurrence Handle12714652

    Article  PubMed  Google Scholar 

  30. A Longo M Geiser CE Riva (2000) ArticleTitleSubfoveal choroidal blood flow response to light-dark exposure Invest Ophthalmol Vis Sci 41 2678–2683 Occurrence Handle10937582

    PubMed  Google Scholar 

  31. C Flügel ER Tamm B Mayer E Lutjen-Drecoll (1994) ArticleTitleSpecies differences in choroidal vasodilative innervation: evidence for specific intrinsic nitrerjic and VIP-positive neurons in the human eye Invest Ophthalmol Vis Sci 35 592–599 Occurrence Handle7509326

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Medical School of Cerrahpasa, Istanbul University, 4, Kisim T.O 94 Bolk D1, l, Ataköy-Istanbu, 34750, Turkey

    Cengiz Aras, Ozcan Ocakoglu & Nilufer Akova

Authors
  1. Cengiz Aras
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ozcan Ocakoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nilufer Akova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cengiz Aras.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aras, C., Ocakoglu, O. & Akova, N. Foveolar Choroidal Blood Flow in Idiopathic Macular Hole. Int Ophthalmol 25, 225–231 (2004). https://doi.org/10.1007/s10792-005-5014-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-005-5014-4

Keywords

Search

Navigation