Abstract
The rate of adolescents with gender-nonconforming behavior and/or gender dysphoria seeking mental health care has dramatically increased in the past decade. Many of these youths also present with co-occurring psychiatric problems, including depression, anxiety, suicidality, substance use, and others. This combination may generate a complex clinical picture that challenges the ability of clinicians to accurately diagnose gender distress and develop suitable treatment recommendations. This article illustrates those challenges with two adolescent patients who developed late-onset gender dysphoria in the course of long-term mental health care for diverse psychiatric problems preceding the emergence of gender dysphoria. One underwent full progression from gender dysphoria as a male through social and medical transition to female, the other a less definitive progression from gender dysphoria as female through social transition to male without deciding for any medical treatment. The report provides details on the assessment procedures and the resulting findings, the rationale for treatment recommendations, and short-term follow-up information.
Similar content being viewed by others
References
Aitken, M., Steensma, T. D., Blanchard, R., VanderLaan, D. P., Wood, H., Fuentes, A., … Zucker, K. J. (2015). Evidence for an altered sex ratio in clinic-referred adolescents with gender dysphoria. Journal of Sexual Medicine, 12, 756–763. https://doi.org/10.1111/jsm.12817.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Press.
Aranda, G., Fernández-Rebollo, E., Pradas-Juni, M., Hanzu, F. A., Kalko, S. G., Halperin, I., & Mora, M. (2017). Effects of sex steroids on the pattern of methylation and expression of the promoter region of estrogen and androgen receptors in people with gender dysphoria under cross-sex hormone treatment. Journal of Steroid Biochemistry and Molecular Biology, 172, 20–28.
Arcelus, J., Claes, L., Witcomb, G. L., Marshall, E., & Bouman, W. P. (2016). Risk factors for non-suicidal self-injury among trans youth. Journal of Sexual Medicine, 13, 402–412.
Bauer, G. R., Scheim, A. I., Pyne, J., Travers, R., & Hammond, R. (2015). Intervenable factors associated with suicide risk in transgender persons: A respondent driven sampling study in Ontario, Canada. BMC Public Health, 15, 525. https://doi.org/10.1186/s12889-015-1867-2.
Bechard, M., VanderLaan, D. P., Wood, H., Wasserman, L., & Zucker, K. J. (2017). Psychosocial and psychological vulnerability in adolescents with gender dysphoria: A “proof of principle” study. Journal of Sex and Marital Therapy, 43, 678–688.
Becker, J., Ravens-Sieberer, U., Ottová-Jordan, V., & Schulte-Markwort, M. (2017). Prevalence of adolescent gender experiences and gender expression in Germany. Journal of Adolescent Health, 61, 83–90.
Berenbaum, S. A. (1999). Effects of early androgens on sex-typed activities and interests on adolescents with congenital adrenal hyperplasia. Hormones and Behavior, 35, 102–110.
Bosinski, H. A., Peter, M., Bonatz, G., Arndt, R., Heidenreich, M., Sippell, W. G., & Wille, R. (1997). A higher rate of hyperandrogenic disorders in female-to-male transsexuals. Psychoneuroendocrinology, 22, 361–380.
Chen, M., Fuqua, J., & Eugster, E. A. (2016). Characteristics of referrals for gender dysphoria over a 13-year period. Journal of Adolescent Health, 58, 369–371.
Connolly, M. D., Zervos, M. J., Barone, C. J., Johnson, C. C., & Joseph, C. L. (2016). The mental health of transgender youth: Advances in understanding. Journal of Adolescent Health, 59, 489–495.
Costa, R., Dunsford, M., Skagerberg, E., Holt, V., Carmichael, P., & Colizzi, M. (2015). Psychological support, puberty suppression, and psychosocial functioning in adolescents with gender dysphoria. Journal of Sexual Medicine, 12, 2206–2214.
de Graaf, N. M., Carmichael, P., Steensma, T. D., & Zucker, K. J. (2018). Evidence for a change in the sex ratio of children referred for gender dysphoria: Data from the Gender Identity Development Service in London (2000–2017). Journal of Sexual Medicine, 15, 1381–1383. https://doi.org/10.1016/j.jsxm.2018.08.002.
Donaldson, A. A., Hall, A., Neukirch, J., Kasper, V., Simones, S., Gagnon, S., … Forcier, M. (2018). Multidisciplinary care considerations for gender nonconforming adolescents with eating disorders: A case series. International Journal of Eating Disorders, 51, 475–479. https://doi.org/10.1002/eat.22868.
Ehrhardt, A. A., & Meyer-Bahlburg, H. F. L. (1984). Gender-role assessment schedule-adult (GRAS-A). Unpublished manuscript (available from the 2nd author).
Feder, S., Isserlin, L., Seale, E., Hammond, N., & Norris, M. L. (2017). Exploring the association between eating disorders and gender dysphoria in youth. Eating Disorders, 25, 310–317.
Holt, V., Skagerberg, E., & Dunsford, M. (2016). Young people with features of gender dysphoria: Demographics and associated difficulties. Clinical Child Psychology and Psychiatry, 21, 108–118.
Hughto, J. M. W., Reisner, S. L., & Pachankis, J. E. (2015). Transgender stigma and health: A critical review of stigma determinants, mechanisms, and interventions. Social Science and Medicine, 147, 222–231.
Leibowitz, S., & de Vries, A. L. (2016). Gender dysphoria in adolescence. International Review of Psychiatry, 28, 21–35.
Meyer-Bahlburg, H. F. L. (2011). Gender monitoring and gender reassignment of children and adolescents with a somatic disorder of sex development. Child and Adolescent Psychiatric Clinics of North America, 20, 639–649.
Meyer-Bahlburg, H. F. L., Dolezal, C., Baker, S. W., Ehrhardt, A. A., & New, M. I. (2006a). Gender development in women with congenital adrenal hyperplasia as a function of disorder severity. Archives of Sexual Behavior, 35, 667–684.
Meyer-Bahlburg, H. F. L., Dolezal, C., Johnson, L. L., Kessler, S. J., Schober, J. M., & Zucker, K. J. (2010). Development and validation of the Infant Orientation Questionnaire. Journal of Sex Research, 47, 598–610.
Meyer-Bahlburg, H. F. L., Dolezal, C., Zucker, K. J., Kessler, S. J., Schober, J. M., & New, M. I. (2006b). The Recalled Childhood Gender Questionnaire-Revised: A psychometric analysis in a sample of women with congenital adrenal hyperplasia. Journal of Sex Research, 43, 364–367.
Meyer-Bahlburg, H. F. L., & Ehrhardt, A. A. (1983). Sexual behavior assessment schedule-adult (SEBAS-A). Unpublished manuscript (available from the authors).
Mueller, A., Gooren, L. J., Naton-Schötz, S., Cupisti, S., Beckmann, M. W., & Dittrich, R. (2008). Prevalence of polycystic ovary syndrome and hyperandrogenemia in female-to-male transsexuals. Journal of Clinical Endocrinology and Metabolism, 93, 1408–1411.
Olson, J., Schrager, S. M., Belzer, M., Simons, L. K., & Clark, L. F. (2015). Baseline physiologic and psychosocial characteristics of transgender youth seeking care for gender dysphoria. Journal of Adolescent Health, 57, 374–380.
Olson-Kennedy, J., Cohen-Kettenis, P. T., Kreukels, B. P., Meyer-Bahlburg, H. F. L., Garofalo, R., Meyer, W., & Rosenthal, S. M. (2016). Research priorities for gender nonconforming/transgender youth: Gender identity development and biopsychosocial outcomes. Current Opinion in Endocrinology, Diabetes, and Obesity, 23, 172–179.
Peterson, C. M., Matthews, A., Copps-Smith, E., & Conard, L. A. (2017). Suicidality, self-harm, and body dissatisfaction in transgender adolescents and emerging adults with gender dysphoria. Suicide and Life-Threatening Behavior, 47, 475–482.
Polderman, T. J. C., Kreukels, B. P. C., Irwig, M. S., Beach, L., Chan, Y. M., Derks, E. M., … International Gender Diversity Genomics Consortium. (2018). The biological contributions to gender identity and gender diversity: Bringing data to the table. Behavior Genetics, 48, 95–108.
Reisner, S. L., Greytak, E. A., Parsons, J. T., & Ybarra, M. L. (2015). Gender minority social stress in adolescence: Disparities in adolescent bullying and substance use by gender identity. Journal of Sex Research, 52, 243–256.
Richards, C., Bouman, W. P., Seal, L., Barker, M. J., Nieder, T. O., & T’Sjoen, G. (2016). Non-binary or gender-queer genders. International Review of Psychiatry, 28, 95–102.
Sasaki, S., Ozaki, K., Yamagata, S., Takahashi, Y., Shikishima, C., Kornacki, T., … Ando, J. (2016). Genetic and environmental influences on traits of gender identity disorder: A study of Japanese twins across developmental stages. Archives of Sexual Behavior, 45, 1681–1695.
Simons, L., Schrager, S. M., Clark, L. F., Belzer, M., & Olson, J. (2013). Parental support and mental health among transgender adolescents. Journal of Adolescent Health, 53, 791–793.
Singh, D., Deogracias, J. J., Johnson, L. L., Bradley, S. J., Kibblewhite, S. J., Owen-Anderson, A., … Zucker, K. J. (2010). The Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults: Further validity evidence. Journal of Sex Research, 47, 49–58.
Wiepjes, C. M., Nota, N. M., de Blok, C. J. M., Klaver, M., de Vries, A. L. C., Wensing-Kruger, S. A., … den Heijer, M. (2018). The Amsterdam Cohort of Gender Dysphoria Study (1972–2015): Trends in prevalence, treatment, and regrets. Journal of Sexual Medicine, 15, 582–590.
Wood, H., Sasaki, S., Bradley, S. J., Singh, D., Fantus, S., Owen-Anderson, A., … Zucker, K. J. (2013). Patterns of referral to a gender identity service for children and adolescents (1976–2011): Age, sex ratio, and sexual orientation [Letter to the Editor]. Journal of Sex and Marital Therapy, 39, 1–6. https://doi.org/10.1080/0092623x.2012.675022.
Zucker, K. J. (2017). Epidemiology of gender dysphoria and transgender identity. Sexual Health, 14, 404–411.
Zucker, K. J., Bradley, S. J., Owen-Anderson, A., Kibblewhite, S. J., Wood, H., Singh, D., & Choi, K. (2012). Demographics, behavior problems, and psychosexual characteristics of adolescents with gender identity disorder or transvestic fetishism. Journal of Sex and Marital Therapy, 38, 151–189. https://doi.org/10.1080/0092623X.2011.611219.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Human and Animal Rights
This article does not contain any studies with human participants or animals performed by the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sevlever, M., Meyer-Bahlburg, H.F.L. Late-Onset Transgender Identity Development of Adolescents in Psychotherapy for Mood and Anxiety Problems: Approach to Assessment and Treatment. Arch Sex Behav 48, 1993–2001 (2019). https://doi.org/10.1007/s10508-018-1362-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10508-018-1362-9