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12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

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Mycoscience

Abstract

Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.

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Acknowledgments

This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas 17035029 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to M. N. We thank Ms. M. Endo and A. Fujita for their excellent technical assistance.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo, 105-8512, Japan

    Taiko Oda

  2. Tohoku Pharmaceutical University, Aoba-ku, Sendai, 981-8558, Japan

    Jinzhong Xu, Kazuyo Ukai, Takahiro Nakazawa & Michio Namikoshi

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  1. Taiko Oda
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  2. Jinzhong Xu
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  3. Kazuyo Ukai
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  4. Takahiro Nakazawa
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  5. Michio Namikoshi
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Correspondence to Michio Namikoshi.

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Oda, T., Xu, J., Ukai, K. et al. 12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity. Mycoscience 51, 317–320 (2010). https://doi.org/10.1007/s10267-010-0035-x

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  • DOI: https://doi.org/10.1007/s10267-010-0035-x

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