Abstract
Nocardiosis is a life-threatening opportunistic infection in immunocompromised patients. Herein, we present successful adjunctive use of liposomal nebulized amikacin and tedizolid in a recipient of allogeneic hematopoietic stem cell transplantation infected with Nocardia nova complex who presented multiple complications to conventional therapeutic options.
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Acknowledgements
The authors gratefully acknowledge Philip Robinson, Anne-Claire Uhres, and Veronica Rodriguez-Nava.
On behalf of the Lyon HEMINF study group: F. Ader, V. Alcazer, E. Bachy, M. Balsat, F. Barraco, M. Boccard, A. Conrad, S. Ducastelle-Leprêtre, O. Dumitrescu, D. Dupont, V. Escuret, E. Ferrant, T. Ferry, E. Frobert, H. Ghesquières, L. Karlin, H. Labussière-Wallet, M-V. Larcher, F. Laurent, B. Lina, G. Lina, J. Menotti, P. Miailhes, G. Monneret, F. Morfin-Sherpa, T. Perpoint, M. Rabodonirina, M. Renault, C. Roure-Sobas, V. Safar, G. Salles, P. Sesques, X. Thomas, F. Valour, F. Venet, F. Wallet, M. Wallon.
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SS contributed to conception and design of the study, acquisition of the data, and drafted the manuscript; CTF, SR, DL, and HLW contributed to acquisition of the data and revision of the paper for important intellectual content; IM carried out the review of PET TDM, imagery selection, and revision of the paper for important intellectual content; OD and EH provided Nocardia strain identification and drug susceptibility testing, and revision of the paper for important intellectual content; FA was the ID senior physician in charge of patients’ management, the project initiator, and drafted the manuscript. All authors cited above have read and approved the final version of the manuscript.
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The detailed outline of the manuscript was explained to the patient who gave his written consent for publication. The consent was then transmitted to the Lyon University Hospital Ethics Committee (Comité d’Ethique, Hospices Civils de Lyon), which approved the study.
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Soueges, S., Triffault-Fillit, C., Roux, S. et al. Long-term use of liposomal nebulized amikacin and tedizolid for the treatment of disseminated nocardiosis after allogeneic hematopoietic stem cell transplantation. Eur J Clin Microbiol Infect Dis 40, 2033–2036 (2021). https://doi.org/10.1007/s10096-021-04186-6
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DOI: https://doi.org/10.1007/s10096-021-04186-6