Abstract
To study the evolution of human X-linked red and green opsin genes, genomic sequences in large regions of the two genes were compared. The divergences in introns 3, 4, and 5 and the 3′ flanking sequence of the two genes are significantly lower than those in exons 4 and 5. The homogenization mechanism of introns and the 3′ flanking sequence of human red and green opsin genes is probably gene conversion, which also occurred in exons 1 and 6. At least one gene conversion event occurred in each of three regions (1,3, and 5) in the sequences compared. In conclusion, gene conversion has occurred frequently between human red and green opsin genes, but exons 2, 3, 4, and 5 have been maintained distinct between the two genes by natural selection.
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References
Asenjo AB, Rim J, Oprian DD (1994) Molecular determinants of human red/green color discrimination. Neuron 12:1131–1138
Drummond-Borg M, Deeb SS, Motulsky AG (1989) Molecular patterns of X chromosome-linked color vision genes among 134 men of European ancestry. Proc Natl Acad Sci USA 86:983–987
Ibbotson R, Hunt DM, Bowmaker JK, Mollon JD (1993) Sequence divergence and copy number of the middle- and long-wave photo-pigment genes in Old World monkeys. Proc R Soc Br 247:145–154
Kimura M (1980) A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 16:111–120
Li WH (1993) Unbiased estimation of the rates of synonymous and nonsynonymous substitution. J Mol Evol 36:96–99
Li WH (1997) Molecular evolution. Sinauer, Sunderland, MA, pp 315–318
Merbs SL, Nathans J (1992a) Absorption spectra of human cone pigments. Nature 356:433–435
Merbs SL, Nathans J (1992b) Absorption spectra of the hybrid pigments responsible for anomalous color vision. Science 258:464–466
Merbs SL, Nathans J (1993) Role of hydroxyl-bearing amino acids in differentially tuning the absorption spectra of the human red and green cone pigments. Photochem Photobiol 58:706–710
Nathans J, Thomas D, Hogness DS (1986) Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science 232:193–202
Neitz M, Neitz J, Jacobs GH (1991) Spectral tuning of pigments underlying red-green color vision. Science 252:971–974
Shyue SK, Li L, Chang BHJ, Li WH (1994) Intronic gene conversion in the evolution of human X-linked color vision genes. Mol Biol Evol 11(3):548–551
Vollrath D, Nathans J, Davis RW (1988) Tandem array of human visual pigment genes at Xq28. Science 240:1669–1671
Winderickx J, Battisti L, Hibiya Y, Motulsky AG, Deeb SS (1993) Haplotype diversity in the human red and green opsin genes: evidence for frequent sequence exchange in exon 3. Hum Mol Genet 2:1413–1421
Zhou YH, Li WH (1996) Gene conversion and natural selection in the evolution of X-linked color vision genes in higher primates. Mol Biol Evol 13(6):780–783
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Zhao, Z., Hewett-Emmett, D. & Li, WH. Frequent gene conversion between human red and green opsin genes. J Mol Evol 46, 494–496 (1998). https://doi.org/10.1007/PL00013147
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DOI: https://doi.org/10.1007/PL00013147