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Beyond the Wobble: The Rule of Conjugates

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Abstract.

A reexamination of the genetic code suggests a rule of conjugates which captures the observed quartet degeneracies without exception. Adenine is the conjugate of cytosine and uracil is the conjugate of guanine. Further analysis reveals that the rule of conjugates is a macrolevel manifestation of the molecular-level hydrogen-bonding and base-stacking interactions at the decoding site. This new perspective is of significance to evolutionary discussions of nucleic acid bases, genetic code, and interactions involving RNAs.

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Authors and Affiliations

  1. Department of Chemistry, Indian Institute of Technology, Hauz Khas, New Delhi-110016, India, , , , , , IN

    Bhyravabhotla Jayaram

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  1. Bhyravabhotla Jayaram
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Received: 29 November 1996 / Accepted: 8 June 1997

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Jayaram, B. Beyond the Wobble: The Rule of Conjugates. J Mol Evol 45, 704–705 (1997). https://doi.org/10.1007/PL00013144

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  • DOI: https://doi.org/10.1007/PL00013144

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