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Reduced Release of DNA from Streptococcus pneumoniae After Treatment with Rifampin in Comparison to Spontaneous Growth and Ceftriaxone Treatment

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Abstract

 In order to study the release of DNA from Streptococcus pneumoniae in vitro during spontaneous growth and treatment with ceftriaxone or rifampin, a semiquantitative polymerase chain reaction was used. During spontaneous growth, high concentrations of bacterial DNA were released. Exposure to 10 μg/ml of ceftriaxone decreased the DNA release, in median, by 19 times (P=0.03 vs. spontaneous growth). Treatment with 10 μg/ml of rifampin led to a reduction of DNA release, in median, by a factor of 49 (P=0.03 vs. ceftriaxone; six experiments performed on different days).

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Authors and Affiliations

  1. Department of Neurology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany e-mail: rnau@gwdg.de Tel.: +49-551-398455 Fax: +49-551-398405, , , , , , DE

    J. Gerber, H. Fleischer, A. Wellmer & R. Nau

  2. Department of Bacteriology, University of Göttingen, Kreuzbergring 57, 37075 Göttingen, Germany, , , , , , DE

    H. Eiffert

  3. Department of Medical Statistics, University of Göttingen, Humboldtallee 32, 37075 Göttingen, Germany, , , , , , DE

    U. Munzel

Authors
  1. J. Gerber
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  2. H. Eiffert
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  3. H. Fleischer
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  4. A. Wellmer
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  5. U. Munzel
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  6. R. Nau
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Gerber, J., Eiffert, H., Fleischer, H. et al. Reduced Release of DNA from Streptococcus pneumoniae After Treatment with Rifampin in Comparison to Spontaneous Growth and Ceftriaxone Treatment. EJCMID 20, 490–493 (2001). https://doi.org/10.1007/PL00011291

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  • DOI: https://doi.org/10.1007/PL00011291

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