Abstract:
Although infectious agents such as Staphylococcus aureus have been implicated in the pathogenesis of Wegener’s granulomatosis, the role of bacterial infections in the pathogenesis of other types of small-vessel vasculitides associated with antineutrophil cytoplasmic antibodies (ANCA) is less clear. We describe a patient who developed a non-granulomatous necrotising small vessel vasculitis and perinuclear ANCA (p-ANCA) directed against myeloperoxidase (MPO) after recurrent episodes of bacterial endocarditis due to Staph. aureus. Although cytoplasmic ANCA (c-ANCA) directed against proteinase 3 have been reported in single patients with bacterial endocarditis, to our knowledge this patient is the first reported case of an anti-MPO-ANCA positive systemic vasculitis following bacterial endocarditis.
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Received: 2 February 2001 / Accepted: 6 June 2001
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Hellmich, B., Ehren, M., Lindstaedt, M. et al. Anti-MPO-ANCA-Positive Microscopic Polyangiitis following Subacute Bacterial Endocarditis. Clin Rheumatol 20, 441–443 (2001). https://doi.org/10.1007/PL00011214
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DOI: https://doi.org/10.1007/PL00011214