Abstract
This paper is a review of studies examining the neurobehavioral antecedents of schizophrenia which flesh out neurodevelopmental models of schizophrenia by detailing the time course of the ontogeney of neurobehavioral impairments in schizophrenia. A follow back design was used to identify precursors of psychotic symptoms in children with a schizophrenic disorder. The vast majority of children with a schizophrenic disorder had significant developmental delays beginning early in life. For example, gross deficits in early language development were found in almost 80% of the schizophrenic children. Somewhat later in development impairments in fine motor and bi-manual coordination are noted. Some of these early developmental delays are transitory. For example, basic language skills are among the best preserved neurocognitive functions in children and adults with schizophrenia. The results of our crosssectional neurocognitive studies suggest that children with schizophrenia suffer from limitations in the ability to engage in effortful cognitive processing or impairments in working memory. The links between these elementary neurocognitive impairments and the development of formal thought disorder as well as discourse deficits in children with a schizophrenic disorder will be discussed.
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Asarnow RF, Nuechterlein KH, Torquato R, Subotnik K, Fogelson D (1997) Paper submitted at the international congress on schizophrenia research. Cognitive/ neuropsychological abnormalities in the parents of children with a schizophrenic disorder
Asarnow JR (1994) Annotation: Childhood-onset schizophrenia. J ChildhPsychol Psychiatry 35: 1345–1371
Asarnow RF, Asarnow JR (1994) Childhood-onset schizophrenia: Editor’s introduction. Schizophr Bull Vol 20 4: 591–597
Asarnow RF, Asamen J, Granholm E, Sherman T, Watkins JM, Williams ME (1994) Cognitive/neuropsychological studies of children with a schizophrenic disorder. Schizophr Bull Vol 20 4: 647–669
Asarnow RF, Granholm E, Sherman T (1991) Span of apprehension in schizophrenia. In: Steinhauer SR, Gruzelier JH, Zubin J (eds), Handbook of Schizophrenia: vol 5. Neuropsychology. Psychophysiology, and Information Processing (pp 335–370). New York: Elsevier
Asarnow JR (1988) Children at risk for schizophrenia. Schizophr Bull 14: 613–632
Asarnow RF, Tanguay PE, Bott L, Freeman BJ (1987) Patterns of intellectual functioning in non-retarded autistic and schizophrenic children. J Child Psychol Psychiatry 28: 273–280
Asarnow RF, Sherman T (1984) Studies of visual information processing in schizophrenic children. Child Dev 55: 249–261
Asarnow RF, MacCrimmon DJ (1982) Attention, information processing, neuropsychological functioning, and thought disorder during the acute and partial recovery phases of schizophrenia: A longitudinal study. Psychiatry Res 1: 309–319
Asarnow RF, MacCrimmon DJ (1978) Residual performance deficit in clinically remitted schizophrenies a marker of schizophrenia? J Abnorm Psychol 87: 597
Asarnow RF, Steffy RA, MacCrimmon DJ, Cleghorn JM (1977) An attentional assessment of foster children at risk for schizophrenia. J Abnorm Psychol 86: 267–275
Bartfai A, Pedersen NL, Asarnow RF, Schalling D (1991) Genetic factors for the span of apprehension test: A study of normal twins. Psychiatry Res 38: 115–124
Bleuler E (1911) Dementia Praecox or the group of schizophrenias. Translated by Zinkin J. New York, NY: International Universities Press 1950
Cannon TD (1997) On the nature and mechanisms of obstetric influences in schizophrenia: A review and synthesis of epidemiologic studies. International Review of Psychiatry 9: 387–397
Eggers CH (1991) Stimulus barrier model of schizophrenia: Convergence of neurobiological and developmental-psychological factors. In: Eggers (ed) Schizophrenia and youth. Etiology and Therapeutic Consequences. Springer: Berlin Heidelberg New York, pp 29–40
Fish G, Marcus J, Hans SL, Auerbach JG, Perdue S (1992) Infants at risk for schizophrenia: sequelae of a genetic neurointegrative defect: A review and replication analysis of pnadysmaturation in the Jerusalem Infant Development Study. Arch Gen Psychiatry 49: 221–235
Fish B (1977) Neurobiologic antecedents of schizophrenia in children. Arch Gen Psychiatry 34: 1297–1313
Gjerde PF (1983) Attentional capacity dysfunction and arousal in schizophrenia. Br J Psychiatry 153: 437–443
Gottesman II, Hanson DR (1982) Introduction. In: Gottesman II, Shields J (1982) Schizophrenia: The Epigenetic Puzzle. New York: Cambridge University Press
Granholm E, Asarnow RF, Marder SR (1991) Controlled information processing resources and the development of automatic detection responses in schizophrenia. J Abnorm Psychology 100: 22–30
Hirst W, Kalmar D (1987) Characterizing attentional resources. J Exp Psychology: General 116: 68–81
Kahneman D (1973) Attention and Effort. Englewood Cliffs, NJ: Prentice-Hall
Kraeplin E (1896) Psychiatrie. Ein Lehrbuch fur Studierende und Ärzte. Barth, Leipzig
Meehl PE (1962) Schizotaxia, schizotypy, schizophrenia. Am Psychologist 17: 827–838
Nuechterlein KH, Dawson ME (1984) Information processing and attentional functioning in the course of schizophrenic disorder. Schizophr Bull 10: 160–203
Nuechterlein KH (1983) Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. J Abnorm Psychology 92: 4–28
Park S, Holzman PS, Goldman-Rakic PS (1995) Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry 52: 821–828
Reitan RM (1958) Validity of the trail making test as an indicator of organic brain damage. Perceptual and motor skills 8: 271–276
Sherman T, Asarnow RF (1985) The cognitive disabilities of the schizophrenic child. In: Sigman M (ed) Children with Emotional Disorders and Developmental Disabilities: Assessment and Treatment, pp 153–170. Grune and Stratton, New York
Schneider W, Dumais ST, Shiffrin RA (1984) Automatic and controlled processing and attention. In: Parasuraman R, Beatty J, Davies J (eds) Varieties of Attention (pp 1–27). Academic, San Diego
Schneider SG, Asarnow RF (1987) A comparison between the cognitive/ neuropsychological impairments of non-retarded autistic and schizophrenic children. J Abnormal Child Psychol 15: 29–46
Watkins JM, Asarnow RF, Tanguay PE (1988) Symptom development in childhood-onset schizophrenia. J Child Psychol 29: 865–878
Watt NF, Lubensky AW (1976) Childhood roots of schizophrenia. J Consult Clin Psychol 44: 363–375
Wickens CD (1984) Processing resources in attention. In: Parasuraman R, Beatty J, Davies J (eds) Varieties of Attention (pp 63–102). New York: Academic Press
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Asarnow, R.F. Neurocognitive impairments in schizophrenia: A piece of the epigenetic puzzle. European Child & Adolescent Psychiatry 8 (Suppl 1), S5–S8 (1999). https://doi.org/10.1007/PL00010684
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DOI: https://doi.org/10.1007/PL00010684