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Near fatal acute colchicine intoxication in a child. A case report

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Abstract

An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastro-intestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug.

Conclusion To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

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Authors and Affiliations

  1. Paediatric Department B, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, , , , , , IL

    Aviv Goldbart

  2. Paediatric Rheumatology Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, , , , , , IL

    Joseph Press

  3. Paediatric Intensive Care Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, , , , , , IL

    Shaul Sofer

  4. Paediatric Haemato-Oncology Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, PO Box 151, Beer-Sheva, Israel e-mail: Kapelush@bgumail.bgu.ac.il Fax: +972-7-6400528, , , , , , IL

    Joseph Kapelushnik

Authors
  1. Aviv Goldbart
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  2. Joseph Press
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  3. Shaul Sofer
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  4. Joseph Kapelushnik
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Received: 24 January 2000 / Accepted: 15 May 2000

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Goldbart, A., Press, J., Sofer, S. et al. Near fatal acute colchicine intoxication in a child. A case report. Eur J Pediatr 159, 895–897 (2000). https://doi.org/10.1007/PL00008364

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  • DOI: https://doi.org/10.1007/PL00008364

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