Abstract.
To study sex differences in mutation rate in primates, we sequenced the third introns of the AMGX and AMGY genes from humans, orangutans, and squirrel monkeys and estimated that the male-to-female ratio of mutation rate is α= 5.14 with the 95% confidence interval (2.42, 16.6). Combining this data set and the data sets from ZFX/ZFY and SMCX/SMCY introns, we obtained an estimate of α= 5.06 with the 95% confidence interval reduced to (3.24, 8.79). The α value is significantly higher in higher primates than in rodents.
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Received: 19 August 1996 / Accepted: 22 November 1996
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Huang, W., Chang, BJ., Gu, X. et al. Sex Differences in Mutation Rate in Higher Primates Estimated from AMG Intron Sequences . J Mol Evol 44 , 463 –465 (1997). https://doi.org/10.1007/PL00006166
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DOI: https://doi.org/10.1007/PL00006166