Abstract.
Ras-related guanosine triphosphatases (GTPases) couple receptor activity to a number of intracellular signalling events culminating in the control of cell morphology and gene transcription. In culture cells, the best-understood Ras-dependent signalling pathway involves the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK) cascade. A growing body of evidence has recently been accumulating to suggest a crucial role of Ras and MAPK signalling in neuronal functions connected to synaptic plasticity. In the present review article we discuss the experimental basis supporting the notion that the Ras/MAPK pathway interacts with other synaptic mechanisms to regulate invertebrate and vertebrate behavioural responses such as those implicated in learning and memory processes.
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Received 21 October 1999; received after revision 27 December 1999; accepted 27 December 1999
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Mazzucchelli, C., Brambilla*, R. Ras-related and MAPK signalling in neuronal plasticity and memory formation . CMLS, Cell. Mol. Life Sci. 57, 604–611 (2000). https://doi.org/10.1007/PL00000722
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DOI: https://doi.org/10.1007/PL00000722