Abstract:
Objective and design: Inflammatory and tumorous bronchi were screened in order to obtain new tumor relevant cytogenetic parameters. Material or subjects: Bronchial cells of 32 patients were cultivated by standard cell culture procedures. Methods: Tetraploidy and aneuploidy was determined by enumeration of chromosome 7 and 8 versus the number of centrosomes. The resulting data were correlated with histopathological data. Results: Tetra- and aneuploidy of epithelial cells were detectable in 76 % of tumor cell cultures, 75 % of high grade inflammatory tissues and 40 % of non- and low grade-inflammatory tissues. Additionally, we observed centrosome hyperamplification and multipolar mitoses not only in the tumor but also in the early stages of inflammation. Conclusion: Inflammatory bronchi already show tumor-specific features and may consequently represent the preliminary genetic stage of cancer development in bronchi.
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Received 20 August 2001; returned for revision 15 January 2002; accepted by M. J. Parnham 19 April 2002
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Lothschütz, D., Jennewein, M., Pahl, S. et al. Polyploidization and centrosome hyperamplification in inflammatory bronchi. Inflamm. res. 51, 416–422 (2002). https://doi.org/10.1007/PL00000323
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DOI: https://doi.org/10.1007/PL00000323