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Reflex control of the human cardiovascular system

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Reviews of Physiology, Biochemistry and Pharmacology, Volume 105

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 105))

Abstract

The surge of knowledge about the autonomic regulation of the human cardiovascular system which commenced in the 1940s was a consequence of many events. These included the information gained from animal studies of the various reflexogenic zones which modulate the circulation, the demonstration of the feasibility of cardiac catheterization in man; the urgent need in the Second World War for information on the effects of gravitational forces on the human cardiovascular system which were encountered in military aircraft; the development of instrumentation and techniques applicable to human studies; and the growing number of clinician-scientists able to divise and conduct appropriate studies and of informed volunteers willing to act as subjects for the experiments. To these should be added the demonstration in 1948, in the splenic nerves of the ox, that norepinephrine was the sympathetic neurotransmitter (von Euler 1948) and in the same year the development of the concept of two types of adrenoceptors, alpha and beta (Ahlquist 1948).

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  1. Mayo Clinic and Foundation, Rochester, Minnesota, USA

    John T. Shepherd

  2. Centro di Fisiologia Clinica e Ipertensione, University of Milan, Milan, Italy

    Giuseppe Mancia

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Shepherd, J.T., Mancia, G. (1986). Reflex control of the human cardiovascular system. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 105. Reviews of Physiology, Biochemistry and Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0034497

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