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Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ (1994). Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 12:155–166
Arancio O, Kandel ER, Hawkins RD (1995) Activity-dependent long-term enhancement of transmitter release by presynaptic 3′,5′-cyclic GMP in cultured hippocampal neurons. Nature 376:74–80
Ardell MD, Aragon I, Oliveira L, Porche GE, Burke E, Pittler SJ (1996) The β subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit. FEBS Lett 389:213–218
Ardell MD, Makhija AK, Olivera L, Miniou P, Viegas-Péquignot E, Pittler SJ (1995) cDNA, gene structure, and chromosomal localisation of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel. Genomics 28:32–38
Baumann A, Frings S, Godde M, Seifert R, Kaupp UB (1994) Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae. EMBO J 13:5040–5050
Baylor D (1996) How photons start vision Proc Natl Acad Sci USA 93:560–565
Beavo JA (1995) Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 75:725–748
Berghard A, Buck LB, Liman ER (1996) Evidence for distinct signaling mechanism in two mammalian olfactory sense organs. Proc Natl Acad Sci USA 93:2365–2369
Biel M, Zong X, Distler M, Bosse E, Klugbauer N, Murakami M, Flockerzi V, Hofmann F (1994) Another member of the cyclic nucleotide-gated channels family expressed in testis, kidney and heart. Proc Natl Acad Sci USA 91:3505–3509
Biel M, Zong X, Hofmann F (1996a) Cyclic nucleotide-gated cation channels: molecular diversity, structure and cellular functions. Trends Cardiovasc Med 6:274–280
Biel M, Zong X, Ludwig A, Sautter A, Hofmann F (1996b) Molecular cloning and expression of a modulatory subunit of the cyclic nucleotide-gated cation channel. J Biol Chem 271:6349–6355
Bönigk W, Altenhofen W, Müller F, Dose A, Illing M, Molday RS, Kaupp UB (1993) Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels. Neuron 10:865–877
Bönigk W, Müller F, Middendorff R, Weyand I, Kaupp UB (1996) Two alternatively spliced forms of the cGMP-gated channel α-subunit from cone photoreceptor are expressed in the chick pineal organ. J Neuroscience 16:7458–7468
Bradley J, Li J, Davidson N, Lester HA, Zinn K (1994) Heteromeric olfactory cyclic nucleotide-gated channels: A new subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci USA 91:8890–8894
Bradley J, Zhang Y, Bakin R, Lester HA, Ronnett GV, Zinn K (1997) Functional expression of the heteromeric “olfactory” cyclic nucleotide-gated channel in hippocampus: a potential effector of synaptic plasticity in brain neurons. J Neuroscience 17:1993–2005
Breer H, Raming K, Krieger J (1994) Signal recognition and transduction in olfactory neurons. Biochim Biophys Acta 1224:277–287
Broillet MC, Firestein S (1996) Direct activation of the olfactory cyclic nucleotidegated channel through modification of sulfhydryl groups by NO compounds. Neuron 16:377–385
Broillet MC, Firestein S (1997) β subunits of the olfactory cyclic nucelotide-gated channel form a nitric oxide activated Ca2+ channel. Neuron 18:951–958
Brown RL, Gramling R, Bert RJ, Karpen JW (1995) Cyclic GMP contact points within the 63-kDa subunit and a 240-kDa associated protein of retinal rod cGMP-activated channels. Biochemistry 34:8365–8370
Brunet LJ, Gold GH, Ngai J (1996) General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17:681–693
Chen TY, Illing M, Hsu YT, Yau KW, Molday RS (1994) Subunit 2 (or β) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca2+-calmodulin modulation. Proc Natl Acad Sci USA 91:11757–11761
Chen TY, Peng YW, Dhallan RS, Ahamed B, Reed RR, Yau KW (1993) A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature 362:764–767
Chen TY, Yau KW (1994) Direct modulation by Ca2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature 368:545–548
Cobbs WH, Barkdoll AE III, Pugh EN Jr (1985) Cyclic GMP increases photocurrent and light sensitivity of retinal cones. Nature 317:64–66
Coburn CM, Bargmann CI (1996) A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans. Neuron 17:695–706
Colamartino G, Menini A, Torre V (1991) Blockage and permeation of divalent cations through the cyclic GMP-activated channel from tiger salamander retinal rods. J Physiol 440:189–206
Colville CA, Molday RS (1996) Primary structure and expression of the human β-subunit and related proteins of the rod photoreceptor cGMP-gated channel. J Biol Chem 271:32968–32974
Cook NJ, Hanke W, Kaupp UB (1987) Identification, purification, and functional reconstitution of the cyclic GMP-dependent channels from rod photoreceptors. Proc Natl Acad Sci USA 84:585–589
Dhallan RS, Yau KW, Schrader KA, Reed RR (1990) Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature 347:184–187
Ding C, Potter ED, Qiu W, Coon SL, Levine MA, Guggino SE (1997) Cloning and widespread distribution of the rat rod-type cyclic nucleotide-gated cation channel. Am J Physiol 272:C1335–1344
Distler M, Biel M, Flockerzi V, Hofmann F (1994) Expression of cyclic nucleotidegated cation channels in non-sensory tissues and cells. Neuropharmacology 33:1275–1282
Doyle DA, Cabral JM, Pfuetzner RA, Kuo A, Gulbis J, Cohen SL, Chait BT, MacKinnon R (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:69–77
Dryer S, Henderson D (1991) A cyclic GMP-activated channel in dissociated cells of chick pineal gland. Nature 353:756–758
Eismann E, Müller F, Heinemann SH, Kaupp UB (1994) A single negative charge within the pore region of a cGMP-gated channel controls rectification, Ca2+ blockage, and ion selectivity. Proc Natl Acad Sci USA 91:1109–1113
Fesenko EE, Kolesnikov SS, Lyubarsky AL (1985) Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segments. Nature 313:310–313
Finn JT, Grunwald ME, Yau KW (1996) Cyclic nucleotide-gated ion channels: an extanded family with diverse functions. Annu Rev Physiol 58:395–426
Finn JT, Solessio EC, Yau KW (1997) A cGMP-gated cation channel in depolarizing photoreceptors of the lizard parietal eye. Nature 385:815–819
Firestein S (1992) Electric signals in olfactory transduction. Current Opinion in Neurobiology 2:444–448
Frings S, Lynch JW, Lindemann B (1992) Properties of cyclic nucleotide-gated channels mediating olfactory transduction: Activation, selectivity, and blockage. J Gen Physiol 100:45–67
Frings S, Seifert R, Godde M, Kaupp UB (1995) Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron 15:169–179
Garbers DL (1989) Molecular basis of fertilization. Annu Rev Biochem 58:719–742
Goldstein SAN (1996) A structural vignette common to voltage sensors and conduction proes: canaliculi. Neuron 16:717–722
Gordon SE, Downing-Park J, Zimmerman AL (1995) Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor. J Physiol 486:533–546
Gordon SE, Oakley JC, Varnum MD, Zagotta WN (1996) Altered ligand specificity by protonation in the ligand binding domain of cyclic nucleotide-gated channels. Biochemistry 35:3994–4001
Gordon SE, Varnum MD, Zagotta WN (1997) Direct interaction between amino-and carboxyl-terminal domains of cyclic nucleotide-gated channels. Neuron 19:431–441
Gordon SE, Zagotta WN (1995a). Subunit interactions in coordination of Ni2+ in cyclic nucleotide-gated channels. Proc Natl Acad Sci USA 92:10222–10226
Gordon SE, Zagotta WN (1995b) Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels. Neuron 14:857–864
Gordon SE, Zagotta WN (1995c) A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors. Neuron 14:177–183
Goulding EH, Tibbs GR, Liu D, Siegelbaum SA (1993) Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels. Nature 364:61–64
Goulding EH, Tibbs GR, Siegelbaum SA (1994) Molecular mechanism of cyclic nucleotide-gated channel activation. Nature 372:369–374
Grunwald ME, Yu WP, Yu HH, Yau KW (1998) Identification of a domain on the β-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin. J Biol Chem 273:9148–9157
Guy HR, Durell SR, Warmke J, Drysdale R, Ganetzky B (1991) Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels. Science 254:730
Hatt H, Ache BW (1994) Cyclic nucleotide-and inositol phosphate-gated ion channels in lobster olfactory neurons. Proc Natl Acad Sci USA 91:6264–6268
Haynes LW (1995a) Permeation of internal and external monovalent cations through the catfish cone photoreceptor cGMP-gated channel. J Gen Physiol 106:485–505
Haynes LW (1995b) Permeation and block by internal and external cations of the catfish cone photoreceptor cGMP-gated channel. J Gen Physiol 106:507–523
Haynes LW, Yau KW (1985) Cyclic GMP-sensitive conductance in outer segment membrane of the catfish cones. Nature 317:61–64
Heginbotham L, Abramson T, MacKinnon R (1992) A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science 258:1152–1155
Henn DK, Baumann A, Kaupp UB (1995) Probing the transmembrane topology of cyclic nucleotide-gated ion channels with a gene fusion approach. Proc Natl Acad Sci USA 92:7425–7429
Hess P, Tsien RW (1984) Mechanism of ion permeation through calcium channels. Nature 309:453–456
Hofmann F, Dostmann W, Keilbach A, Landgraf W, Ruth P (1992) Structure and physiological role of cGMP-dependent protein kinase. Biochem Biophys Acta 1135:51–60
Hofmann F, Ludwig A, Pfeifer A (1994) Cyclic GMP and the control of airways smooth muscle tone. In: Raeburn D, Giembycz MA (eds) Airways smooth muscle: Biochemical control of contraction and relaxation. Birkhäuser Verlag, Basel, pp 253–269
Hoshi T, Zagotta WN, Aldrich RW (1990) Biophysical and molecular mechanism of Shaker potassium channel inactivation. Science 250:533–538
Hsu YT, Molday RS (1993) Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin. Nature 361:76–79
Ikura M, Clore GM, Gronenborn AM, Zhu G, Klee CB, Bax A (1992) Solution structure of a calmodulin-target peptide complex by multidimensional NMR. Science 256:632–638
Jan LY, Jan YN (1992) Structural elements involved in specific K+ channel functions. Annu Rev Physiol 54:537–555
Kaupp UB, Niidome T, Tanabe T, Terada S, Bönigk W, Stühmer W, Cook NJ, Kangawa K, Matsuo H, Hirose T, Miyata T, Numa S (1989) Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 342:762–766
Kingston PA, Zufall F, Barnstable CJ (1996) Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: novel targets for cAMP/cGMP function. Proc Natl Acad Sci USA 93:10440–10445
Komatsu H, Mori I, Rhee JS, Akaike N, Ohshima Y (1996) Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17:707–718
Körschen HG, Illing M, Seifert R, Sesti F, Williams A, Gotzes S, Colville C, Müller F, Dose A, Godde M, Molday L, Kaupp UB, Molday RS (1995) A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor. Neuron 15:627–636
Kramer RH, Goulding E, Siegelbaum SA (1994) Potassium channel inactivation peptide blocks cyclic nucleotide-gated channels by binding to the conserved pore domain. Neuron 12:655–662
Kumar VD, Weber IT (1992) Molecular model of the cyclic GMP-binding domain of the cyclic GMP-gated ion channel. Biochemistry 31:4643–4649
Kurahashi T, Menini A (1997) Mechanism of odorant adaptation in the olfactory receptor cell. Nature 385:725–729
Liman ER, Buck LB (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron 13:611–621
Liu DT, Tibbs GR, Siegelbaum SA (1996) Subunit stoichiometry of cyclic nucleotide-gated channels and effects of subunit order on channel function. Neuron 16:983–990
Liu M, Chen TY, Ahamed B, Li J, Yau KW (1994) Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel. Science 266:1348–1354
MacKinnon R (1995) Pore loops: an emerging theme in ion channel structure. Neuron 14:889–892
McKay DB, Steitz TA (1981) Structure of catabolite gene activator protein at 2.9 A resolution suggests binding to left-handed B-DNA. Nature 290:744–749
Menini A (1990) Currents carried by monovalent cations through cyclic GMP-activated channels in excised patches from salamander rods. J Physiol 424:167–185
Misaka T, Kusakabe Y, Emori Y, Gonoi T, Arai S, Abe K (1997) Taste buds have a cyclic nucleotide-activated channel, CNGgust. J Biol Chem 272:22623–22629
Molday RS, Molday LL, Dose A, Clark-Lewis I, Illing M, Cook NJ, Eismann E, Kaupp UB (1991) The cGMP-gated channel of the rod photoreceptor cell: Characterization and orientation of the amino terminus. J Biol Chem 266:21917–21922
Nakamura T, Gold GH (1987) A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325:442–444
Nawy S, Jahr CE (1991) cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter. Neuron 7:677–683
Root MJ, MacKinnon R (1993) Identification of an external divalent cation-binding site in the the pore of a cGMP-activated channel. Neuron 11:459–466
Ruiz ML, Karpen JW (1997) Single cyclic nucleotide-gated channels locked in different ligand-bound states. Nature 389:389–392
Sautter A, Biel M, Hofmann F (1997) Molecular cloning of cyclic nucleotide-gated cation channel subunits from rat pineal gland. Mol Brain Res 48:171–175
Sautter A, Zong X, Hofmann F, Biel M (1998). An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons. Proc Natl Acad USA 95:4696–4701
Savchenko A, Barnes S, Kramer RH (1997) Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide. Nature 390:694–698
Schaad NC, Vanecek J, Rodriguez IR, Klein DC, Holtzclaw L, Russel JT (1995) Vasoactive intestinal peptide elevates pinealocyte intracellular calcium concentrations by enhancing influx: evidence for involvement of a cyclic GMP-dependent mechanism. Mol Pharmacol 47:923–933
Sesti F, Eismann E, Kaupp UB, Nizzari M, Torre V (1995) The multi-ion nature of the cGMP-gated channel from vertebrate rods. J Physiol 487:17–36
Shabb JB, Corbin JD (1992) Cyclic nucleotide-binding domains in proteins having diverse functions. J Biol Chem 267:5723–5726
Shiells RA, Falk G (1990) Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein. Proc R Soc Lond 242:91–94
Sugimoto Y, Yatsunami K, Tsujimoto M, Khorana HG, Ichikawa A (1991) The amino acid sequence of a glutamic acid-rich protein from bovine retina as deduced from the cDNA sequence. Proc Natl Acad Sci USA 88:3116–3119
Sun ZP, Akabas MH, Goulding EH, Karlin A, Siegelbaum SA (1996) Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating. Neuron 16:141–149
Tang CY, Papazian DM (1997) Transfer of voltage independence from a rat olfactory channel to the Drosophila ether-à-go-go K+-channel. J Gen Physiol 109:301–311
Thompson SH (1997) Cyclic GMP-gated channels in a sympathetic neuron cell line. J Gen Physiol 110:155–164
Tibbs GR, Goulding EH, Siegelbaum SA (1997) Allosteric activation and tuning of ligand efficacy in cyclic nucleotide-gated channels. Nature 86:612–615
Torre V, Straforini M, Sesti F, Lamb TD (1992) Different channel-gating properties of two classes of cyclic GMP-activated channel in vertebrate photoreceptors. Proc R Soc London Ser B 250:209–215
Vaandrager AB, De Jonge HR (1994) Effect of cyclic GMP on intestinal transport. Adv Pharmacol 26:252–282
Varnum MD, Black KD, Zagotta WN (1995) Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels. Neuron 15:619–625
Varnum MD, Zagotta WN (1997) Interdomain interactions underlying activation of cyclic nucleotide-gated channels. Science 278:110–113
Weitz D, Zoche M, Müller F, Beyermann M, Körschen HG, Kaupp UB, Koch KW (1998) Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the N-terminus of the β-subunit. EMBO J 17:2273–2284
Weyand I, Godde M, Frings S, Weiner J, Müller F, Altenhofen W, Hatt H, Kaupp UB (1994) Cloning and functional expression of a cyclic nucleotide-gated channel from mammalian sperm. Nature 368:859–863
Yang J, Ellinor PT, Sather WA, Zhang JF, Tsien RW (1993) Molecular determinants of Ca2+ selectivity and ion permeation of L-type Ca2+ channels. Nature 366:158–161
Yau KW, Nakatani K (1985) Light-suppressible, cyclic GMP-sensitive conductance in the plasma membrane of a truncated rod outer segment. Nature 317:252–255
Zagotta WN, Siegelbaum SA (1996) Structure and function of cyclic nucleotide-gated channels. Annu Rev Neurosci 19:235–263
Zimmerman AL, Baylor DA (1992) Cation interactions within the cyclic GMP-activated channel of retinal rods from the tiger salamander. J Physiol 449:759–783
Zong X, Zucker H, Hofmann F, Biel M (1998) Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels. EMBO J 17:353–362
Zufall F, Firestein S (1993) Divalent cations block the cyclic nucleotide-gated channel of olfactory receptor neurons. J Neurophysiol 69:1758–1768
Zufall F, Firestein S, Shepherd GM (1994) Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu Rev Biophys Biomol Struct 23:577–607
Zufall F, Shepherd GM, Barnstable CJ (1997) Cyclic nucleotide-gated channels as regulator of CNS development and plasticity. Curr Opin Neurobiol 7:404–412
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Biel, M., Zong, X., Ludwig, A., Sautter, A., Hofmann, F. (1999). Structure and function of cyclic nucleotide-gated channels. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 135. Reviews of Physiology, Biochemistry and Pharmacology, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0033672
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