Skip to main content
SpringerLink
Log in

Molecular design of temperature-responsive polymers as intelligent materials

  • Chapter
  • First Online:
Responsive Gels: Volume Transitions II

Part of the book series: Advances in Polymer Science ((POLYMER,volume 110))

Abstract

In recent years, temporal control of drug delivery has been of interest in basic and applied fields as a new approach to achieve improved drug therapies. This new drug delivery may be achieved by utilization of “intelligent” polymeric materials having the functions of sensing, processing and acting. Stimuli-responsive polymers have been investigated as potential molecular devices to achieve intelligent drug delivery systems such as self-regulating and externally nodulated drug delivery systems.

In this chapter, temperature responsive swelling-shrinking changes in hydrogels were reviewed from the view point of polymer-water interaction and polymer-polymer interaction. In particular, characteristics of interpenetrating polymer networks (IPN) constructed of two distinct polymers which lead to novel temperature-responsive swelling changes were discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

PIPAAm:

poly(N-isopropyl acrylamide)

RMA:

alkyl methacrylate

PEO:

poly(ethylene oxide)

APy:

poly(acryloylpyrrolidine)

PMAA:

poly(methacrylic acid)

PAAm:

polyacrylamide

PAAc:

poly(acrylic acid)

IPN-X:

Interpenetrating polymer networks of poly(AAm-co-BMA) (BMA X wt%) and PAAc (AAm:AAc=1:1)

NVP:

N-vinyl-2-pyrrolidone

PBA:

m-aminophenyl-boric acid

PVA:

poly(vinyl alcohol)

7 References

  1. Okano T, Bae YH, Kim SW (1990) In: Kost J (ed) Pulsed and self-regulated drug delivery. CRC Press, Boca Raton, FL, p 17

    Google Scholar 

  2. Bae YH, Okano T, Kim SW (1990) J Polym Sci B Polym Phys 28: 923

    Article  Google Scholar 

  3. Bae YH, Okano T, Kim SW (1991) Pharm Res 8: 531

    Article  PubMed  Google Scholar 

  4. Bae YH, Okano T, Kim SW (1987) Macromol Chem. Rapid Commun 8: 481

    Article  Google Scholar 

  5. Okano T, Bae YH, Jacobs H, Kim SW (1990) J Controlled Release 11: 255

    Article  Google Scholar 

  6. Bae YH, Okano T, Sakurai Y (1991) Pharm Res 8: 624

    Article  PubMed  Google Scholar 

  7. Yoshida R, Sakai K, Okano T, Sakurai Y (1991) Polym J 23: 1111

    Article  Google Scholar 

  8. Yoshida R, Sakai K, Okano T, Sakurai Y (1992) J Biomater Sci Polym Edn 3: 243

    Google Scholar 

  9. Yoshida R, Sakai K, Okano T, Sakurai Y (1992) Ind Eng Chem Res 31: 2339

    Article  Google Scholar 

  10. Sakai K, Ozawa K, Mimura R, Ohashi H (1987) J Membrance Sci 32: 3

    Article  Google Scholar 

  11. Yoshida R, Sakai K, Okano T, Sakurai Y (1991) J Biomater Sci Polym Edn 3: 155

    Google Scholar 

  12. Molyneux P (1984) Interactions between polymers. In: Water-soluble synthetic polymers: Properties and behavior, vol II, CRC Press, Boca Raton, FL, USA, p 159

    Google Scholar 

  13. Mukae K, Bae YH, Okano T, Kim SW (1990) Polym J 22: 206

    Article  Google Scholar 

  14. Bae YH, Okano T, Kim SW (1988) Makromol Chem Rapid Commun 9: 185

    Article  Google Scholar 

  15. Baranovsky VY, Litomanovich AA, Papisov IM, Kabanov VA (1981) Euro Polym J 17: 969

    Article  Google Scholar 

  16. Osada Y (1979) J Polym Sci 17: 3485

    Google Scholar 

  17. Osada Y, Sato M (1976) J Polym Sci Polym Lett Ed 14: 129

    Article  Google Scholar 

  18. Osada Y, Sato M (1980) Polym Lett Ed 14: 1057

    Google Scholar 

  19. Osada Y, Takeuchi Y (1983) Polym J 15: 279

    Google Scholar 

  20. Osada Y (1977) J Polym Sci Polym Chem Ed 15: 255

    Article  Google Scholar 

  21. Osada Y (1980) J Polym Sci 18: 281

    Google Scholar 

  22. Bailay FE, Lundberg RD, Callard RW (1964) J Polym Sci Part A, 2: 845

    Article  Google Scholar 

  23. Smith KL, Winslow AE, Petersen DE (1959) Ind Eng Chem 51: 1361

    Article  Google Scholar 

  24. Litmanovich AA, Papisov IM, Kabanov VA (1981) Euro Polym J 17: 981

    Article  Google Scholar 

  25. Iliopoulos I, Audebert R (1985) Polym Bull 13: 171

    Google Scholar 

  26. Bedner B, Li Z, Huang Y, Chang LCP, Morawetz H (1985) Macromolecules 18: 1829

    Article  Google Scholar 

  27. Oyama HT, Tang WT, Frank CW (1987) Macromolecules 20: 474

    Article  Google Scholar 

  28. Heyward JJ, Ghiggino KP (1989) Macromolecules 22: 1159

    Article  Google Scholar 

  29. Oyama HT, Hemker DJ, Frank CW (1989) Macromolecules 22: 1255

    Article  Google Scholar 

  30. Bednar B, Morawetz H, Shafer JA (1984) Macromolecules 17: 1634

    Article  Google Scholar 

  31. Abe K, Koide M, Tsuchida E (1977) Macromolecules 10: 1259

    Article  Google Scholar 

  32. Iliopoulos I, Audebert RA (1991) Macromolecules 24: 2566

    Article  Google Scholar 

  33. Bekturov EA, Bimendina LA (1981) Adv Polym Sci 41: 99

    Google Scholar 

  34. Tsuchida E, Abe K (1982) Adv Polym Sci 45: 1

    Google Scholar 

  35. Adachi H, Nishi S, Kotaka T (1982) Polym J 14: 985

    Google Scholar 

  36. Nishi S, Kotaka T (1985) Macromolecules 18: 1519

    Article  Google Scholar 

  37. Nishi S, Kotaka T (1986) Macromolecules 19: 978

    Article  Google Scholar 

  38. Silberberg A, Eliassaf J, Katchalsky A (1957) J Polym Sci 23: 259

    Article  Google Scholar 

  39. Klenina OV, Fain EG (1981) Polym Sci USSR 23: 1439

    Article  Google Scholar 

  40. Katono H, Maruyama A, Sanui K, Ogata N, Okano T, Sakurai Y (1991) J Controlled Release, 16: 215

    Article  Google Scholar 

  41. Ilmain F, Tanaka T, Kokufuta E (1991) Nature, 349: 400

    Article  Google Scholar 

  42. Katono H, Sanui K, Ogata N, Okano T, Sakurai Y (1991) Polymer J 23: 1179

    Article  Google Scholar 

  43. Kitano S, Kataoka K, Koyama Y, Okano T, Sakurai Y (1991) Makromol Chem Rapid Commun 12: 227

    Article  Google Scholar 

  44. Kitano S, Hisamitsu I, Koyama Y, Kataoka K, Okano T, Sakurai Y (1991) Polym Adv Tech 2: 261

    Article  Google Scholar 

  45. Kitano S, Koyama Y, Kataoka K, Okano T, Sakurai Y (1991) J Control Release 19: 162

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biomedical Engineering, Tokyo Women's Medical College, Shinjuku-ku, 162, Tokyo, Japan

    Teruo Okano

Authors
  1. Teruo Okano
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

K. Dušek

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag

About this chapter

Cite this chapter

Okano, T. (1993). Molecular design of temperature-responsive polymers as intelligent materials. In: Dušek, K. (eds) Responsive Gels: Volume Transitions II. Advances in Polymer Science, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0021133

Download citation

  • DOI: https://doi.org/10.1007/BFb0021133

  • Received:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56970-1

  • Online ISBN: 978-3-540-47836-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation