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Mixed-ligand complexes of ruthenium(II) incorporating a diazo ligand: Synthesis, characterization and DNA binding

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Abstract

Mixed-ligand complexes of the type [Ru(N-N)2(dzdf)]Cl2, where N-N is 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen) and 9-diazo-4,5-diazafluorene (dzdf), have been synthesized and characterized by elemental analysis, UV-Vis, IR and NMR spectroscopy. Binding of these complexes with calf thymus DNA (CT-DNA) has been investigated by absorption spectroscopy, steady-state emission spectroscopy and viscosity measurements. The experimental results indicate that the size and shape of the intercalating ligands have marked effect on the binding affinity of the complexes to CT-DNA. The complex [Ru(phen)2(dzdf)]Cl2 binds with CT-DNA through an intercalative binding mode, while the complex [Ru(bpy)2(dzdf)]Cl2 binds electrostatically.

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Authors and Affiliations

  1. Department of Chemistry, University of Pune, Pune, 411 007, India

    Megha S Deshpande & Avinash S Kumbhar

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  1. Megha S Deshpande
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  2. Avinash S Kumbhar
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Correspondence to Avinash S Kumbhar.

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Dedicated to the memory of the late Professor Bhaskar G Maiya

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Deshpande, M.S., Kumbhar, A.S. Mixed-ligand complexes of ruthenium(II) incorporating a diazo ligand: Synthesis, characterization and DNA binding. J Chem Sci 117, 153–159 (2005). https://doi.org/10.1007/BF03356110

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