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Biosynthesis and distribution of opioid peptides

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References

  1. Hughes J., Smith T.W., Kosterlitz H.W., Fothergill L.H., Morgan B.A., Morris H. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 255: 577, 1978.

    Google Scholar 

  2. Guillemin R., Ling N., Burgus R. Endorphines, peptides, d’origine hypothalamique et neurohypophysaire a activité morphinomimetique. Isolement et structure moleculaire de l’or-endorphine. CR. Acad. Sci (D) (Paris) 283: 783, 1976.

    Google Scholar 

  3. Li C.H., Chung D. Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands. Proc. Natl. Acad. Sci. USA 73: 1145, 1976.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  4. Goldstein A., Tachibana S., Lowney L.J., Hunkapiller M., Hood L. Dynorphin-(1–13), an extraordinarily potent opioid peptide. Proc. Natl. Acad. Sci. USA 76: 6666, 1979.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  5. Kangawa K., Matsuo H., Igarashi M. α-neo-endorphin: A “big” Leu-enkephalin with potent opiate activity from porcine hypothalami. Biochem. Biophys. Res. Commun. 86: 153, 1979.

    Article  PubMed  CAS  Google Scholar 

  6. Noda M., Furutani J., Takahashi H., Toyosato M., Hirose T., Inayama S., Nakanishi S., Numa S. Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature 295: 202, 1982.

    Article  PubMed  CAS  Google Scholar 

  7. Minamino N., Kangawa K., Chino N., Sakakibara S., Matsuo H. Beta-neo-endorphin, a new hypothalamic “big” Leu-enkephalin of porcine origin: its purification and the complete amino acid sequence. Biochem. Biophys. Res. Commun. 99: 864, 1981.

    Article  CAS  Google Scholar 

  8. Kakidani H., Furutani Y., Takahashi H., Noda M., Morimoto Y., Hirose T., Asai M., Inayama S., Nakanishi S., Numa S. Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor. Nature 298: 245, 1982.

    Article  PubMed  CAS  Google Scholar 

  9. Imura H. ACTH, β-endorphin and related peptides. In: Cumming I.A., Funder J.W., Mendelsohn F.A. (Eds.) Endocrinology 1980, Australian Academy of Science, Canberra, 1980, p. 58.

    Google Scholar 

  10. Nakanishi S., Taii S., Hirata Y., Matsukura S., Imura H., Numa S. A large product of cell-free translation of messenger RNA coding for corticotropin. Proc. Natl. Acad. Sci. USA 73: 4319, 1976.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  11. Nakanishi S., Inoue A., Kita T., Nakamura M., Chang A.C.Y., Cohen S.N., Numa S. Nucleotide sequence of cloned cDNA for bovine corti-cotropin-β-lipotropin precursor. Nature 278: 423, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Tanaka I., Nakai Y., Jingami H., Fukata J., Nakao K., Oki S., Nakanishi S., Numa S., Imura H. Existence of γ-melanotropin (γ-MSH)-like immunoreac-tivity in bovine and human pituitary glands. Biochem. Biophys. Res. Commun. 94: 211, 1980.

    Article  PubMed  CAS  Google Scholar 

  13. Imura H., Nakai Y., Nakao K., Oki S., Tanaka I. Control of biosynthesis and secretion of ACTH, endor phins and related peptides. In: Muller E.E., MacLeod R.M. (Eds.), Neuroendocrine perspectives. Elsevier Biomedical Press, 1982, Vol. 1, p. 137.

    CAS  Google Scholar 

  14. Zakarian S., Smyth D. Distribution of active and inactive forms of endorphins in rat pituitary and brain. Proc. Natl. Acad. Sci. USA 76: 5972, 1979.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  15. Mains R.E., Eipper B.A. Differences in the post-translational processing of /3-endorphin in rat anterior and intermediate pituitary. Proc. Natl. Acad. Sci. USA 256: 5683, 1981.

    CAS  Google Scholar 

  16. Tsukada T., Nakai Y., Jingami H., Imura H., Taii S., Nakanishi S., Numa S. Identification of the mRNA coding for the ACTH-β-lipo- tropin precursor in a human ectopic ACTH-producing tumor. Biochem. Biophys. Res. Commun. 98: 535, 1981.

    Article  PubMed  CAS  Google Scholar 

  17. Nakao K., Nakai Y., Oki S., Horii K. Imura H. Presence of immunoreactive β-endorphin in normal human plasma: a concomitant release of β-endorphin with adrenocorticotropin after metyrapone administra tion. J.Clin. Invest. 62: 1395, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  18. Nakao K., Oki S., Tanaka I., Nakai Y., Imura H. Concomitant secretion of γ-MSH with ACTH and β-en dorphin in humans. J. Clin. Endocrinol. Metab. 57:1205, 1980.

    Article  Google Scholar 

  19. Oki S., Nakao K., Tanaka I., Horii K., Nakai Y., Shimbo S., Watanabe M., Nakane T., Kuwayama, S., Kageyama N., Imura H. Concomitant secretion of adrenocorticotropin, /3-endorphin and y-melanotropin from perifused pituitary tumor cells of Cushing’s disease: effect of lysine vasopressin, rat median eminence extracts, thyrotropin-releasing hormone and luteinizing hormone-releasing hormone. J. Clin. Endocrinol. Metab. 52: 42, 1981.

    Article  PubMed  CAS  Google Scholar 

  20. Nakao K., Oki S., Tanaka I., Horii K., Nakai Y., Furui T., Fukushima M., Kuwayama A., Kageyama N., Imura H. Immunoreactive /3-endorphin and ACTH in human cerebrospinal fluid. J. Clin. Invest. 66:1383, 1980.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  21. Stern A.S., Lewis R.V., Kimura S., Rossier J., Gerber L.D., Brink L, Stein S., Udenfriend S. Isolation of the opioid heptapeptide Met-enkephalin (Arg6, Phe7) from bovine adrenal’ medullary granules and striatum. Proc. Natl. Acad. Sci. USA 76: 6680, 1979.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  22. Kilpatrick D.L, Jones B.N., Kojima K., Udenfriend S. Identification of the octapeptide (Met) enkephalin-Arg6-Gly7-Leu8 in extracts of bovine adrenal medulla. Biochem. Biophys. Res. Commun. 103: 698, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Kilpatrick D.L, Taniguchi T., Jones B.N., Stern A.S., Shively J.E., Hullihan J., Kimura S., Stern S., Udenfriend S. A highly potent 3200-dalton adrenal opioid peptide that contains both a (Met)-and (Leu) enkephalin sequence. Proc. Natl. Acad. Sci. USA 78: 3265, 1981.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  24. Yoshimasa T., Nakao K., Ohtsuki H., Li S., Imura H. Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma. J. Clin. Invest. 69:643, 1982.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  25. Ikeda Y., Nakao K., Yoshimasa T., Yanaihara N., Numa S., Imura H. Existence of Met-enkephalin-Arg6-Gly7-Leu8 with Met-enkephalin, Leu-enkephalin and Met-enkephalin-Arg6-Phe7 in the brain of guinea pig, rat and golden hamster. Biochem. Biophys. Res. Commun. 107: 656, 1982.

    Article  PubMed  CAS  Google Scholar 

  26. Kilpatrick D.L, Lewis R.V., Stein S., Udenfriend S. Release of enkephalins and enkephalin-containing pep tides from perfused beef adrenal glands. Proc. Natl. Acad. Sci. USA 77: 7473, 1980.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  27. Gubler U., Seeberg P., Hoffman B.J., Gage L.P., Udenfriend S. Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptide. Nature 295: 202, 1982.

    Article  Google Scholar 

  28. Seizinger B.R., Hollt V., Herz A. Evidence for the occurrence of the opioid octapeptide dynorphin-(1-8) in the neurointermediate pituitary of rats. Biochem. Biophys. Res. Commun. 102: 197, 1981.

    Article  PubMed  CAS  Google Scholar 

  29. Minamino N., Kangawa K., Fukuda A., Matsuo H. A new opioid octapeptide related to dynorphin from porcine hypothalamus. Biochem. Biophys. Res. Communio: 1475, 1980.

    Google Scholar 

  30. Weber E., Roth K.A., Barchas J.D. Immunohistochemical distribution of α-neo-endorphin-dynorphin neuronal system in rat brain: evidence for colocalization. Proc. Natl. Acad. Sci. USA 79: 3062, 1982.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

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Plenary lecture, XIX Meeting of the Italian Society of Endocrinology, Genova, May 11–14, 1982.

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Imura, H., Nakai, Y., Nakao, K. et al. Biosynthesis and distribution of opioid peptides. J Endocrinol Invest 6, 139–149 (1983). https://doi.org/10.1007/BF03350587

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