Abstract
Pretreatment with methysergide, a blocker of serotoninergic receptors, significantly reduced the TSH response to TRH in six male volunteers. The TRH-induced PRL release was also slightly decreased, while plasma GH levels were not significantly modified by TRH either during the control period or after methysergide. These results indicate that alterations of central nervous system monoaminergic pathways may modify the hypophysiotropic effects of TRH.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bowers C.Y., Friesen H.G., Hwang P., Guyda H.G., Folkers K. Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide. Biochem. Biophys. Res. Commun. 45: 1033, 1971.
Jacobs L.S., Snyder P.J., Wilber J.F., Utiger R.D., Daughday W.H. Increased serum prolactin after administration of synthetic thyrotropin releasing hormone (TRH) in man. J. Clin. Endocrinol. Metab. 33: 996, 1971.
Irie M., Tsushima T. Increase of serum growth hormone concentration following thyrotropin-releasing hormone injection in patients with acromegaly or gigantism. J. Clin. Endocrinol. Metab. 35: 97, 1972.
Schalch D.S., Gonzalez-Barcena D., Kastin A.J., Schally A.V., Lee L.A. Abnormalities in the release of TSH in response to thyrotropin-releasing hormone (TRH) in patients with disorders of the pituitary, hypothalamus and basal ganglia. J. Clin. Endocrinol. Metab. 35: 609, 1972.
Gonzalez-Barcena D., Kastin A.J., Schalch D.S., Torres-Zamora M., Perez-Pasten E., Kato A., Schally A.V. Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men. J. Clin. Endocrinol. Metab. 36: 117, 1973.
Maeda K., Kato Y., Ohgo S., Chihara K., Yoshimoto Y., Yamaguchi N., Kuromaru S., Imura H. Growth hormone and prolactin release after injection of thyrotropin-releasing hormone in patients with depression. J. Clin. Endocrinol. Metab. 40: 501, 1975.
Maeda K., Kato Y., Yamaguchi N., Chihara K., Ohgo S., Iwasaki Y., Yoshimoto Y., Moridera K., Kuromaru S., Imura H. Growth hormone release following thyrotropin-releasing hormone injection into patients with anorexia nervosa. Acta Endocrinol. (Kbh) 81: 1, 1976.
Collu R., Leboeuf G., Letarte J., Ducharme J.R. Increase in plasma growth hormone levels following thyrotropin-releasing hormone injection in children with primary hypothyroidism. J. Clin. Endocrinol. Metab. 44: 888, 1977.
Douglas W.W. Histamine and antihistamines; 5-hydroxytryptamine and antagonists. In: Goodman LS., and Gilman A. (Eds.). The pharmacological basis of therapeutics. Macmillian Co. Ltd., London, 4th edition 1970, p 621.
Odell W.D., Wilber J.F., Paul W.E. Radioimmunoassay of thyrotropin in human serum. J. Clin. Endocrinol. Metab. 25: 1179, 1965.
Sinha Y.N., Selby F.W., Lewis U.J., Vanderlaan W.P. A homologous radioimmunoassay for human prolactin. J. Clin. Endocrinol. Metab. 36: 509, 1973.
Schalch O.S., Parker M.L A sensitive double antibody immunoassay for human growth hormone in plasma. Nature 203: 1141, 1964.
Egge A.C., Rogol A.O., Varina M.M., Blizzard R.M. Effect of cyproheptadine on the TRH-stimulated prolactin and TSH release in man. J. Clin. Endocrinol. Metab. 44: 210, 1977.
Stone C.A., Wenger H.C., Ludden C.T., Stavorski J.M., Ross, C.A. Antiserotonin-antihistaminic properties of cyproheptadine. J. Pharmacol. Exp. Ther. 131: 73, 1961.
Gilbert J.C., Goldberg J.I. Characterization by cyproheptadine of the dopamine-induced contraction in canine isolated arteries J. Pharmacol. Exp. Ther. 193: 435, 1975.
Bivens C.H., Lebovitz H.E., Feldman J.M. Inhibition of hypoglycemia-induced growth hormone secretion by the serotonin antagonists cyproheptadine and methysergide. N. Engl. J. Med. 289: 236, 1973.
Mendelson W.B., Jacobs L.S., Reichman J.D., Othmer E., Cryer P.E., Trivedi B., Daughaday W.H. Suppression of sleep-related prolactin secretion and enhancement of sleep-related growth hormone secretion. J. Clin. Invest. 56: 690, 1975.
Chihara K., Kato Y., Maeda K., Matsukura S., Imura H. Suppression by cyproheptadine of human growth hormone and Cortisol secretion during sleep. J. Clin. Invest. 57: 1393, 1976.
Creese I., Burt O.R., Snyder S.H. The dopamine receptor: differential binding of d-LSD and related agents to agonist and antagonist states. Life Sci. 17: 1715, 1975.
Burrow G.N., May P.B., Spaulding S.W., and Donabedian R.K. TRH and dopamine interactions affecting pituitary hormone secretion J. Clin. Endocrinol Metab. 45: 65, 1977.
Ferrari C., Paracchi A., Rondena M., Beck-Peccoz P., Faglia G. Effect of two serotonin antagonists on prolactin and thyrotropin secretion in man. Clin. Endocrinol. 5: 575, 1976.
Chiodini P.G., Liuzzi A., Müller E.E., Botalla L., Cremascoli A., Oppizzi G., Verde A., Silvestrini F. Inhibitory effect of an ergoline derivative, methergoline, on growth hormone and prolactin levels in acromegalic patients J. Clin. Endocrinol. Metab. 43: 356, 1976.
Collu R., Clermont M.J., Letarte J., Leboeuf G., Ducharme J.R. Inhibition of pentobarbital-induced release of growth hormone by thyrotropin-releasing hormone. Endocrinol. Res. Commun. 2: 123, 1975.
Collu R., Clermont M.J., Ducharme J.R. Effects of thyrotropin-releasing hormone on prolactin, growth hormone and corticosterone secretions in adult male rats treated with pentobarbital or morphine. Eur. J. Pharmacol. 37: 133, 1976.
Tache Y., Du Ruisseau P., Ducharme J.R., Collu R. Antagonism of pentobarbital-induced hormonal changes by TRH in rats. Eur. J. Pharmacol. 45: 369, 1977.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Collu, R. The effect of TRH on the release of TSH, PRL and GH in man under basal conditions and following methysergide. J Endocrinol Invest 1, 121–124 (1978). https://doi.org/10.1007/BF03350358
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03350358