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Isolated growth hormone deficiency after severe head trauma

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Abstract

In a 12-yr-old boy growth arrest occurred after severe head trauma. Evaluation of pituitary endocrine function revealed isolated growth hormone (GH) deficiency. Lack of GH response to GH-releasing factor indicated that the responsible lesion was most likely to be localized in the pituitary gland. GH substitution resulted in biochemical (somatomedin increase) and clinical (catch up growth) response.

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References

  1. Tanner J.M., Whitehouse R.H., Takaishi M. Standards from birth to maturity for height, weight, height velocity and weight velocity: british children. Arch. Dis. Child. 41: 454 and 613, 1966.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  2. Greulich W.W., Pyle S.I. Radiographic atlas of skeletal development of hand and wrist, 2nd ed. Stanford University Press, California, 1959.

    Google Scholar 

  3. Frisch H. Wachstumshormon-Mangel bei Kindern. Beurteilung hypophysärer Funktionstests. Therapie und Verlaufskontrolle. Facultas Verlag, Wien, 1983.

    Google Scholar 

  4. Barreca T., Perria C., Sannia A., Magnani G., Rolandi E. Evaluation of anterior pituitary function in patients with posttraumatic diabetes insipidus. J. Clin. Endocrinol. Metab. 51: 1279, 1980.

    Article  PubMed  CAS  Google Scholar 

  5. Israel S.L., Conston A.S. Unrecognized pituitary necrosis (Sheehan’s syndrome): a cause of sudden death. J.A.M.A. 148: 189, 1952.

    Article  CAS  Google Scholar 

  6. Klachka D.M., Winer N., Burns T.W., White J.E. Traumatic hypopituitarism occurring before puberty: survival 35 years untreated. J. Clin. Endocrinol. Metab. 28: 1768, 1968.

    Article  Google Scholar 

  7. Landau H. Pituitary insufficiency after head injury. Isr.J. Med. Sci. 14: 785, 1978.

    PubMed  CAS  Google Scholar 

  8. Porter R.J., Miller R.A. Diabetes insipidus following closed head injury. J. Neurol. Neurosurg. Psychiatry 11: 258, 1948.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Sheehan H.L, Murdoch R. Post-partum necrosis of the anterior pituitary: pathological and clinical aspects. J. Obstet. Gynaecol. Br. Emp. 45: 456, 1938.

    Article  Google Scholar 

  10. Paxson C.L., Brown DR. Posttraumatic anterior hypopituitarism. Pediatrics 57: 893, 1975.

    Google Scholar 

  11. Fink E.B. Diabetes insipidus: a clinical review and analysis of necropsy reports. Arch. Pathol. 6: 102, 1928.

    CAS  Google Scholar 

  12. Goldman K.P., Jacos A. Anterior and posterior pituitary failure after head injury: report of two cases. J. Clin. Endocrinol. Metab. 5: 119, 1945.

    Article  Google Scholar 

  13. Holbourn A.H.S. Mechanics of head injuries. Lancet 2: 438, 1943.

    Article  Google Scholar 

  14. Valenta L.J., De Feo D. Posttraumatic hypopituitarism due to a hypothalamic lesion. Am. J. Med. 68: 614, 1980.

    Article  PubMed  CAS  Google Scholar 

  15. Crompton M.R. Hypothalamic lesions following closed head injury. Brain 94: 165, 1971.

    Article  PubMed  CAS  Google Scholar 

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Eichler, I., Frisch, H., Eichler, H.G. et al. Isolated growth hormone deficiency after severe head trauma. J Endocrinol Invest 11, 409–411 (1988). https://doi.org/10.1007/BF03349069

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