Abstract
Two azoospermic patients with isolated hypogonadotropic hypogonadism (IHH) no. 1, 24-year-old, and no. 2, 31-year-old), never treated before, were given gonadotropin therapy (GT) (FSH, 225 IU/week, and HCG, 4000 IU/week) and followed up monthly for sperm characteristics. After 6 (no.1) and 9 (no. 2) months of treatment, immotile spermatozoa appeared in the semen. Two months later motile spermatozoa also appeared. A motile sperm concentration sufficiently high for computer motion analysis (CASA) was achieved 1 month later 9th and 12th month, respectively. At the 13th (no.1) and 17th (no.2) month of GT, CASA showed a small population of spermatozoa with a very good motility pattern. In the next ovulatory cycle the patients’ partners became pregnant.
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This work was supported by MURST 60% Grants and by CNR targeted Project “Prevention and Control of Diseases Factors”, Subproject “Control of Human Fertility” Grant n. 9200082.
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Lenzi, A., Lombardo, F., Gandini, L. et al. Computer assisted sperm motility analysis at the moment of induced pregnancy during gonadotropin treatment for hypogonadotropic hypogonadism. J Endocrinol Invest 16, 683–686 (1993). https://doi.org/10.1007/BF03348911
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DOI: https://doi.org/10.1007/BF03348911