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Advances in the medical and surgical treatment of pituitary adenomas: The role of long-acting somatostatin analogs

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References

  1. Reubi J.C., Landolt A.M. The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status. J. Clin. Endocrinol. Metab. 68: 844, 1989.

    Article  CAS  PubMed  Google Scholar 

  2. Spada A., Reza-Elahi F., Lania A., Gil del Alamo P., Bassetti M., Faglia G. Alterations in receptor status and postreceptor events in human pituitary tumors. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam, 1991, p. 95.

    Google Scholar 

  3. Schonbrunn A. Somatostatin action in pituitary cells involves two independent transduction mechanisms. Metabolism. 39 (Suppl. 2): 96, 1990.

    Article  CAS  PubMed  Google Scholar 

  4. Daughaday W.H., Starkey R.H., Saltman S., Gavin J.R. III, Mills-Dunlap B., Heath-Monnig E. Characterization of serum growth hormone (GH) and insulin-like growth factor I in active acromegaly with minimal elevation of serum GH. J. Clin. Endocrinol. Metab. 65: 617, 1987.

    Article  CAS  PubMed  Google Scholar 

  5. Clemmons D.R., Van Wyk J.J., Ridgway E.C., Kliman B., Kjellberg R.N., Underwood L.E. Evaluation of acromegaly by radioimmunoassay of Somatomedin-C. N. Engl. J. Med. 301: 1138, 1977.

    Article  Google Scholar 

  6. Chiodini P.G., Liuzzi A., Botalla L., Oppizzi G., Müller E.E., Silvestrini F. Stable reduction of plasma growth hormone (hGH) levels during chronic administration of 2 Br-alfa-ergocryptine (CB 154) in acromegalic patients. J. Clin. Endocrinol. Metab. 40: 705, 1975.

    Article  CAS  PubMed  Google Scholar 

  7. Plewe G., Beyer J., Krause U., Neufeld M., Del Pozo E. Long-acting and selective suppression of growth hormone secretion by somatostatin analogue SMS 201–995 in acromegaly. Lancet 2: 782, 1984.

    Article  CAS  PubMed  Google Scholar 

  8. Lamberts S.W.J., Oosterom R., Neufeld M., Del Pozo E The somatostatin analog SMS 201–995 induces longacting inhibition of growth hormone secretion without rebound hypersecretion in acromegalic patients. J. Clin. Endocrinol. Metab. 60: 1161, 1985.

    Article  CAS  PubMed  Google Scholar 

  9. Harris A.G., Prestele H., Herold K., Boerlin V. Long-term efficacy of Sandostatin (SMS 201–995, octreotide) in 178 patients: results from the international multicenter acromegaly study group. In: Lamberts S.W.J. (Ed.), Sandostatin in the treatment of acromegaly. Springer, Berlin 1988, pp. 117.

    Chapter  Google Scholar 

  10. Tauber J.P., Babin T., Tauber M.T., Vigoni F., Bonafe A., Ducasse M., Harris A.G., Bayard F. Long-term effects of continuous subcutaneous infusion of the somatostatin analog octreotide in the treatment of acromegaly. J. Clin. Endocrinol. Metab. 68: 917, 1989.

    Article  CAS  PubMed  Google Scholar 

  11. Lamberts S.W.J., Uitterlinden P., Schnijff P.C., Klijn J.G.M. Therapy of acromegaly with Sandostatin: the predictive value of an acute test, the value of somatomedin-C measurements in dose adjustment and the definition of a biochemical “cure”. Clin. Endocrinol. (Oxf) 29: 411, 1988.

    Article  CAS  Google Scholar 

  12. Giovanelli M., Losa M., Baiguini M., Motti E., Ducati A. Transcranial vs. transsphenoidal approach in the surgical treatment of pituitary adenomas. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam 1991, p. 313.

    Google Scholar 

  13. Ross D.A., Wilson C.B. Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. J. Neurosurg. 68: 854, 1988.

    Article  CAS  PubMed  Google Scholar 

  14. Landolt A.M., Lllig R., Zapf J. Surgical treatment of acromegaly. In: Lamberts S.W.J. (Ed.), Sandostatin in the treatment of acromegaly. Springer, Berlin, 1988, pp. 23.

    Chapter  Google Scholar 

  15. Losa M., Oeckler R., Schopohl J., Müller O.A., Alba-Lopez J., von Werder K. Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegaly. J. Neurosurg. 70: 561, 1989.

    Article  CAS  PubMed  Google Scholar 

  16. Falhbusch R., Buchfelder M., Huk W.J., Nistor R., Steinmeier R., Zrinzo A. Correlation between MRI and intraoperative findings in pituitary adenomas. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam, 1991, pp. 245.

    Google Scholar 

  17. Barkan A., Lloyd R.V., Chandler W.F., Hatfield M.K., Gebarski S.S., Kelch R.P., Beitins I.Z. Preoperative treatment of acromegaly with long-acting somatostatin analog SMS 201–995: Shrinkage of invasive pituitary macroadenomas and improved surgical remission rate. J. Clin. Endocrinol. Metab. 67: 1040, 1988.

    Article  CAS  PubMed  Google Scholar 

  18. Nicola G.C., Tonnarelli G., Griner A.C., Zancaner F., Picozzi P., Roccucci P. Surgery for recurrence of pituitary adenomas. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam, 1991, p. 329.

    Google Scholar 

  19. Laws E.R. Jr., Fode N.C., Redmond M.J. Transsphenoidal surgery following unsuccessful prior therapy. An assessment of benefits and risks in 158 patients. J. Neurosurg. 63: 823, 1985.

    Article  PubMed  Google Scholar 

  20. D’Enideu M.C., Harrison L.C. Rapid improvement in visual field defects following bromocriptine treatment of patients with non-functioning pituitary adenomas. Clin. Endocrinol. (Oxf) 25: 697, 1986.

    Article  Google Scholar 

  21. Warnet A., Timsit J., Chanson P., Guillausseau P.J., Zamfirescu F., Harris A.G., Derome P., Cophignon J., Lubetzki J. The effect of somatostatin analogue on chiasmal dysfunction from pituitary macroadenomas. J. Neurosurg. 71: 687, 1989.

    Article  CAS  PubMed  Google Scholar 

  22. Faglia G., Bazzoni N., Spada A., Arosio M., Ambrosi B., Spinelli F., Sara R., Bonino C., Lunghi F. In vivo detection of somatostatin receptors in patients with functionless pituitary adenoma by means of a radioiodinated analog of somatostatin ([123-I] SDZ 204-090). J. Clin. Endocrinol. Metab. 73: 850, 1991.

    Article  CAS  PubMed  Google Scholar 

  23. Oppenheim D.S., Klibanski A. Medical therapy of glycoprotein hormone-secreting pituitary tumors. Endocr. Metab. Clin. North Am. 18: 339, 1989.

    CAS  Google Scholar 

  24. Ebersold M.J., Quast L.M., Laws E.R. Jr. Long-term results in transsphenoidal removal of nonfunctioning pituitary adenomas. J. Neurosurg. 64: 713, 1986.

    Article  CAS  PubMed  Google Scholar 

  25. Kovalic J.J., Grigsby P.W., Fineberg B.B. Recurrent pituitary adenomas after surgical resection: The role radiation therapy. Radiology 177: 273, 1990.

    CAS  PubMed  Google Scholar 

  26. Molitch M.E., Russell E.J. The pituitary “incidentaloma”. Ann. Intern. Med. 112: 925, 1990.

    Article  CAS  PubMed  Google Scholar 

  27. Buchfelder M., Fahlbusch R., Becher W., Mann H. TSH-sezernierende Hypophysenadenome. Med. Welt 42: 1033, 1991.

    Google Scholar 

  28. Gesundheit N., Petrich P.A., Nissim M., Dahlberg A., Doppman J.L., Emerson C.H., Lewis E., Braverman LE., Oldfield E.H., Weintraub B.D. Thyrotropin-secreting pituitary adenomas: Clinical and biochemical heterogeneity. Case reports and follow-up of nine patients. Ann. Intern. Med. 111: 827, 1987.

    Article  Google Scholar 

  29. Beckers A., Abs R., Mahler C., Vandalem J.L., Pirens G., Hennen G., Stevenaert A. Thyrotropin-secreting pituitary adenomas: Report of seven cases. J. Clin. Endocrinol. Metab. 72: 477, 1991.

    Google Scholar 

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Authors

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Participants of the “Conference on Medical and Surgical Treatment of Pituitary Adenomas” (Zürich, 5th October, 1991)

The meeting was supported by an educational grant by Sandoz Pharmaceutics, Germany and Italy.

G.C. Andrioli (Dept. of Neurosurgery, Ospedale Galliera, Genova), C. Anile (Dept. of Neurosurgery, Università Cattolica, Roma), D. Billeci (Dept. of Neurosurgery, Ospedale di Treviso, University of Padova, Treviso), R. Buonaguidi (Institute of Neurosurgery, University of Pisa, Pisa), G. Camboni (Sandoz Pharmaceutics, Milano), A. Carteri (Dept. of Neurosurgery, Ospedale di Treviso, University of Padova, Treviso), H.J. Dennler (Sandoz Pharmaceutics, Nürnberg), G. Faglia (Istitute of Endocrine Sciences, University of Milano, Milano), B. Fraioli (Dept. of Neurosurgery, Università La Sapienza, Roma), G. Frank (Dept. of Neurosurgery, Ospedale Bellaria, Bologna), G. Galli (Chair of Neurosurgery, University of Brescia, Brescia), E. Halves (Dept. of Neurosurgery, Krankenhaus Altona, Hamburg), O. Hey (Dept. of Neurosurgery, University of Mainz, Mainz), G. Hildebrandt (Dept. of Neurosurgery, University of Köln, Köln), E. Knosp (Dept. of Neurosurgery, University of Mainz, Mainz), A.M. Landolt (Klinik im Park, Zürich), A. Liuzzi (Dept. of Endocrinology, Ospedale Niguarda, Milano), D.K. Lüdecke (Dept. of Neurosurgery, University of Hamburg, Hamburg), G. Maira (Dept. of Neurosurgery, Università Cattolica, Roma), G. Marini (Chair of Neurosurgery, University of Brescia, Brescia), G.C. Nicola (Dept. of Neurosurgery, Istituto Neurologico Besta, Milano), R. Oeckler (Dept. of Neurosurgery, Klinikum Groβhadern, University of München, München), U. Plöckinger (Dept. of Endocrinology, Klinikum Steglitz, University of Berlin, Berlin), H.J. Quabbe (Dept. of Endocrinology, Klinikum Steglitz, University of Berlin, Berlin), M. Renoldi (Sandoz Pharmaceutics, Milano), W. Saeger (Dept. of Pathology, Marienkrankenhaus, Hamburg), M. Scanarini (Dept. of Neurosurgery, University of Padova, Padova), J. Schramm (Dept. of Neurosurgery, University of Bonn, Bonn), N. Sicolo (Dept. of Internal Medicine, University of Padova, Padova), A. Spada (Institute of Endocrine Sciences, University of Milano, Milano), R. Spaziante (Dept. of Neurosurgery, Università Federico II, Napoli), W.I. Steudel (Dept. of Neurosurgery, University of the Saarland, Homburg), F. Tomasello (Dept. of Neurosurgery, University of Messina, Messina), K. von Werder (Dept. of Medicine, Schloβpark Klinik, University of Berlin, Berlin), V. Wiederhold (Sandoz Pharmaceutics, Nürnberg), J. Zimmermann (Sandoz Pharmaceutics, Nürnberg).

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Fahlbusch, R., Giovanelli, M., Buchfelder, M. et al. Advances in the medical and surgical treatment of pituitary adenomas: The role of long-acting somatostatin analogs. J Endocrinol Invest 16, 449–460 (1993). https://doi.org/10.1007/BF03348882

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