Abstract
A 47-year old woman is presented who had a left adrenal pheochromocytoma with manifestations also indicative of ectopic ACTH syndrome. The excised adrenal gland showed both an adrenal medullary tumor and adrenal cortical hyperplasia. Immunostaining also showed the presence in the tumor of ACTH and beta endorphins. The immediate post-adrenalectomy decline of catecholamines, ACTH, Cortisol and beta endorphins indicate that the adrenal itself was the source of these hormones. This patient, the thirteenth now reported in the literature, represents one form of ectopic ACTH syndrome in which the lesion is benign, and in which a successful outcome can be anticipated.
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Neff F.C., Tice G., Walker G.A., Ockerblad N. Adrenal tumor in female infant. J. Clin. Endocrinol. Metab. 2: 125, 1942.
Le Compte P.M. Cushing’s syndrome with possible pheochromocytoma. Am. J. Pathol. 20: 689, 1944.
Williams G.A., Crockett C.L., Butler W.W.S., Crispell K.R. The coexistence of pheochromocytoma and adrenocortical hyperplasia. J. Clin. Endocrinol. Metab. 20: 622, 1960.
Bourgoigne J., Dupont J.-C., Noiret R. Association d’un pheochromocytome et d’un hypercorticisme du type Cushing avec hyperaldosteronurie. Ann. Endocrinol. (Paris) 25: 269, 1964.
Meloni C.R., Tucci J., Canary J.J., Kyle L.H. Cushing’s syndrome due to bilateral adrenocortical hyperplasia caused by a benign adrenal medullary tumour. J. Clin. Endocrinol. Metab. 26: 1192, 1966.
O’Neal W.O., Kipnis D.M., Luse S.A. Secretion of various endocrine substances by ACTH-secreting tumours — gastrin, melanotropin, norepinephrine, serotonin, parathormone, vasopressin, glucagon. Cancer 21: 1219, 1968.
Schteingart D.E., Conn J.W., Orth D.N. Secretion of ACTH and α-MSH by an adrenal medullary paraganglioma. J. Clin. Endocrinol. Metab. 34: 674, 1972.
Kley H.K., Blessing M.H., Nieschlag E., Wiegelmann W., Solbach H.G., Kruskemper H.L. Virilismus bei Nebennieren-marktumor mit ektopischern ACTH Syndrom. Klin. Wochenshr. 53: 321, 1975.
Burmeister P., Simon A. Episodische Secretion von ACTH durch einen Tumor des Nebennierenmarks. Dtsch. Med. Wochenschr. 100: 1132, 1975.
Berenyi M.R., Singh G., Gloster E.S., Davidson M.I., Woldenberg D.H. ACTH producing pheochromocytoma. Arch. Pathol. Lab. Med., 101: 31, 1977.
Forman B.H., Marban E., Kayne R.D., Passarelli N.M., Bobrow S.N., Livolsi V.A., Merino M., Minor M., Farber L.R. Ectopic ACTH syndrome due to pheochromocytoma: case report and review of literature. Yale J. Biol. Med. 52: 181, 1979.
Spark R.F., Connolly P.B., Gluckin D.S., White R., Sacks B., Landsberg L. ACTH secretion from a functioning pheochromocytoma. N.Engl. J. Med. 301: 416, 1979.
Hoffman L., Martin F.I.R., Buchanan M.R.C., Batkus A., Whitworth J.A. Cushing’s syndrome due to an ACTH-secreting adrenal medullary tumour. Aust. NZ. J. Med. 70: 654, 1980.
Kovacs K., Corenblum B., Sirek A.M.T., Penz G., Ezrin C. Localization of prolactin in chromophobe pituitary ade nomas: A study of human necropsy material by immunoperoxidase technique. J. Clin. Pathol. 29: 250, 1976.
Linnoila R.I., Nettesheim P., Di Augustine R.P. Lung endocrine-like cells in hamsters treated with diethylnitrosamine: Alterations in vivo and in cell culture. Proc. Nat. Acad. Sci. USA 78: 5170, 1981.
Finley J.C., Lindsfrom P., Petrusz P. Immunocytochemical localization of beta-endorphin-containing neurons in the rat brain. Neuroendocrinology 33: 28, 1981.
Miller R.J., Chang K.J., Cooper B., Cuatrecasas P.S. Radioimmunoassay and characterization of enkephalins in rat tissues. J. Biol. Chem., 253: 531, 1978.
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Schroeder, J.O., Asa, S.L., Kovacs, K. et al. Report of a case of pheochromocytoma producing immunoreactive ACTH and beta-endorphin. J Endocrinol Invest 7, 117–122 (1984). https://doi.org/10.1007/BF03348400
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DOI: https://doi.org/10.1007/BF03348400