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Thyroid function and plasma immunoglobulins in subjects with Down’s syndrome (DS) during ontogenesis and zinc therapy

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Abstract

Thyroid function parameters and immunoglobulin concentrations in sera of outpatients with Down’s syndrome (DS, n=110) of different ages (DS1= 1–9 years; DS2= 6–15; DS3= 15–35) were compared with those of age-matched controls (n=110). Although mean serum TSH was higher in all DS groups, thyroid hormone concentrations were significantly lower only in DS3. In DS1, a notable frequency rate of high T4 and T3 was found. Serum concentrations of thyroxine binding globulin (TBG) were significantly higher in all DS groups. Free T4 and T3 indexes, calculated as the ratio of total hormone: TBG concentrations, were lower in all DS groups. IgA serum concentrations were significantly higher in all DS groups, IgA was higher in DS1 and DS2. Serum zinc levels were lower in all DS groups. Repeated examination after one year revealed lower T4 and higher TSH in DS patients treated with zinc during this interval as compared to values observed before treatment. Our results suggest a high occurrence rate of complex immune and endocrine disorders with thyroid dysregulation in DS patients, with zinc deficiency playing a considerable role.

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References

  1. Lejeune J., Gautier M., Turpin R. Etude des chromosomes somatique de neuf enfantes mongolien. C.R. Seances Acad. Sci. (Paris) 248: 1721, 1953.

    Google Scholar 

  2. Wolozin B., Scicutella A., Davies P. Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA 85: 6202, 1988.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  3. Dewald G.W., Diez-Martin J.L., Steffen S.L., Jenkins R.B., Stupca P.J., Burgert E.O. Hematologic disorders in 13 patients with acquired trisomy 2 and 13 individuals with Down syndrome. Am. J. Med. Genet. (Suppl.) 7: 247, 1990.

    CAS  Google Scholar 

  4. Oster J., Mikkelsen M., Nielsen A. Mortality and life-able in Down syndrome. Acta Paediatr. Scand. 64: 322, 1975.

    Article  PubMed  CAS  Google Scholar 

  5. Saxena K.M., Pryles C.V. Thyroid function in mongolism. J. Pediatr. 67: 363, 1965.

    Article  PubMed  CAS  Google Scholar 

  6. Cutler A.T., Benezra-Obeiter R., Brink S.T. Thyroid function in young children with Down syndrome. Am. J. Dis. Child. 140: 479, 1986.

    PubMed  CAS  Google Scholar 

  7. Kennedy R.L., Jones T.H., Cuckle H.S. Down’s syndrome and the thyroid. Clin. Endocrinol. (Oxf.) 37: 471, 1992.

    Article  CAS  Google Scholar 

  8. Lobo E.H., Khan M., Tew J. Community study of hypothyroidism in Down’s syndrome. Br. Med. J. 1: 1253, 1980.

    Article  Google Scholar 

  9. Burgio G.R., Lanzanecchia A., Maccario R., Vitiello A., Ugazio A.G. Immunodeficiency in Down syndrome: T lymphocyte subset imbalance in trisomie children. Clin. Exp. Immunol. 33: 298, 1978.

    PubMed Central  PubMed  CAS  Google Scholar 

  10. Ugazio A.G., Maccario R., Norarangelo J.D., Burgio G.R. Immunology of Down syndrome. A review. Am. J. Med. Genet. (Suppl.) 7: 204, 1990.

    CAS  Google Scholar 

  11. Zori R.T., Desmond A.S., Ostrer H., Williams C.A., Spillar R., Riley W.J. Relationship of autoimmunity to thyroid dysfunction in children with Down syndrome. Am. J. Med. Genet. (Suppl.) 7: 238, 1990.

    CAS  Google Scholar 

  12. Bjorkestén B., Bäck O., Gustavson K.H., Hallmans G., Häglof B., Tämvik A. Zinc and immune function in Down’s syndrome. Acta Pediatr. Scand. 69: 183, 1980.

    Article  Google Scholar 

  13. Prasad A.S. Clinical, endocrinological and biochemical effects of zinc deficiency. Clin. Endocrinol. Metabol. 14: 567, 1985.

    Article  CAS  Google Scholar 

  14. Sharav T., Collins R.M., Baab P.J. Growth studies in infants and children with Down’s syndrome and elevated levels of thyrotropin. Am. J. Dis. Child. 142: 1302, 1988.

    PubMed  CAS  Google Scholar 

  15. Pueschel S.M., Pezzullo J.C. Thyroid dysfunction in Down’s syndrome. Am. J. Dis. Child. 139: 636, 1985.

    PubMed  CAS  Google Scholar 

  16. Crino A., Gianotti A., Digilio M.C., Albertini G., De Marchi C., Borelli P. Evaluation of elevated levels of TSH in children and adolescents with Down’s syndrome. J. Endocrinol. Invest. (Suppl. 3) 13: 76, 1990.

    Google Scholar 

  17. Burr W.A., Ramsden D.B., Evans S.E., Hogan T., Hoffenberg R. Concentration of thyroxine-binding globulin: value of direct assay. Br. Med. J. 1: 485, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  18. Pozzan G.B., Rigon F., Girelli M.E., Rubello D., Busnardo B., Bacchietti C. Thyroid function in patients with Down syndrome: Preliminary results from non-institutionalized patients in the Veneto region. Am. J. Med. Genet. (Suppl.) 7: 57, 1990.

    CAS  Google Scholar 

  19. Sharav T. Thyroid dysfunction and growth retardation Down’s syndrome. In: Castells S., Wisniewski K.E. (Eds.), Growth hormone treatment in Down’s syndrome. John Wiley & Sons, Chichester, 1993, p. 73.

    Google Scholar 

  20. Crino A., Ciampalini P., DiGiglio M.C., Obregon M.G., Gianotti A., Borrelli P. Abnormal thyrotropin secretion in Down’s syndrome In: Castells S., Wisniewski K.E. (Eds.), Growth hormone treatment in Down’s syndrome. John Wiley & Sons, Chichester, 1993, p. 101.

    Google Scholar 

  21. Glass C.K., Holloway J.M. Regulation of gene expression by the thyroid hormone receptor. Biochim. Biophys. Acta 1032: 157, 1990.

    PubMed  CAS  Google Scholar 

  22. Wada S., King J.C. Effects of low zinc intake on basal metabolic rate, thyroid hormones and protein utilization in adult men. J. Nutr. 116: 1045, 1986.

    PubMed  CAS  Google Scholar 

  23. Napolitano G., Palka G., Lio S., Bucci I., De Remigis P., Stuppia L., Monaco F. Is zinc deficiency a cause of subclinical hypothyroidism in Down syndrome? Ann. Genet. 33: 9, 1990.

    CAS  Google Scholar 

  24. Licastro F., Mocchegiani E., Zanotti M., Arena G., Masi M., Fabris N.A. Zinc affects the metabolism of thyroid hormones in children with Down’s syndrome: normalization of thyroid stimulating hormone and of reversal triiodothyronine plasmic levels by dietary zinc supplementation. Int. J. Neurosc. 65: 259, 1992.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Immunology, Children’s Hospital, Bratislava, Slovakia

    M. S̆ustrová

  2. Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, Bratislava, 83306, Slovakia

    Vladimir S̆trbák M.D.

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  1. M. S̆ustrová
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  2. Vladimir S̆trbák M.D.
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S̆ustrová, M., S̆trbák, V. Thyroid function and plasma immunoglobulins in subjects with Down’s syndrome (DS) during ontogenesis and zinc therapy. J Endocrinol Invest 17, 385–390 (1994). https://doi.org/10.1007/BF03347724

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  • DOI: https://doi.org/10.1007/BF03347724

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