Abstract
ABSTRACT. A 38-yr-old woman with a history of malignant melanoma (MM) presented with a thyroidal nodule. Fine needle aspiration biopsy of the thyroid was consistent with metastatic MM. The patient underwent thyroidectomy: microscopic examination revealed a follicular carcinoma nodule harboring a focus of metastatic melanoma. On review of the fine needle aspiration biopsy specimen, the population of cells with more uniform nuclei with focal follicle formation, which initially was interpreted as cells originating from normal thyroid tissue, was seen to actually represent the follicular carcinoma component. Tumor-to-tumor metastasis is an interesting phenomenon and there are only few cases of MM metastasis to other tumors. MM metastasis into a neoplastic thyroid nodule is a very rare combination and may be explained because the nodule in question represents the most highly vascularized component of the thyroid.
Similar content being viewed by others
References
Giuffrida D, Ferrau F, Pappalardo A, et al. Metastasis to the thyroid gland: a case report and review of literature. J Endocrinol Invest 2003, 26: 560–3.
Haugen BR, Nawaz S, Cohn A, et al. Secondary malignancy of the thyroid gland: a case report and review of literature. Thyroid 1994, 4: 297–300.
Wolf G, Aigner RM, Schwarz T, Nicoletti R. Diagnosis of malignant melanoma in the thyroid with f18-FDG PET scan. Hautarzt 2002, 53: 332–3.
Wolf G, Aigner RM, Humer-Fuchs U. Renal cell carcinoma metastasis in a microfollicular adenoma of the thyroid gland. Acta Med Austriaca 2002, 29: 141–2.
Grignon DJ, Ro JY, Ayala AG. Malignant melanoma with metastasis to adenocarcinoma of the prostate. Cancer 1989, 63: 196–8.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Terzi, A., Altundag, K., Saglam, A. et al. Isolated metastasis of malignant melanoma into follicular carcinoma of the thyroid gland. J Endocrinol Invest 27, 967–968 (2004). https://doi.org/10.1007/BF03347543
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03347543