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Plasma somatostatin-like immunoreactivity and somatostatin-28 levels in obese men

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Abstract

Somatostatin (SS) impairs nutrient absorption. It has been suggested that hyposomatostatinaemia may be involved in the pathogenesis of obesity. However, data on postprandial SS-like immunoreactivity (SLI) levels in obese subjects are controversial and the levels of SS-28, the main molecular form of circulating SLI in healthy subjects, have not been determined. To characterise the fasting and postprandial plasma pattern of SLI and SS-28 in obese men, we studied eight obese men (age 24–32 yr, BMI 33–42 kg/m2), with normal glucose tolerance test and normal gastric emptying of solids, and eight healthy men (age 24–39 yr, BMI 21–24 kg/m2). Blood samples were taken at regular intervals in fasting conditions and for 2 h after a standard solid-liquid meal (2.3 MJ). Plasma SLI and SS-28 were measured by RIA. Our results showed that fasting and postprandial plasma SLI and SS-28 levels were not significantly different in healthy and obese subjects. In conclusion SS-28 is the predominant form of circulating SLI in obese subjects. The normal pattern of fasting and postprandial plasma SLI and SS-28 levels in such subjects suggests that somatostatin does not have a pathogenetic role in obesity.

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Authors and Affiliations

  1. Istituto di Scienze Mediche, Università di Milano, IRCCS-Ospedale Maggiore di Milano, Padiglione Granelli, Via F. Sforza 35, 20122, Milano, Italy

    Maddalena Peracchi M.D., F. Carola, B. Bareggi & G. Basilisco

  2. II Cattedra di Endocrinologia, Università di Milano, Istituto Scientifico Ospedale S. Luca, Milano, Italy

    F. Cavagnini

  3. Servizio di Medicina Nucleare, IRCCS-Ospedale Maggiore di Milano, Milano, Italy

    R. Benti

  4. Istituto Scientifico Ospedale S. Giuseppe, Piancavallo, Verbania, Italy

    G. Baccalaro

Authors
  1. Maddalena Peracchi M.D.
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  2. F. Carola
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  3. F. Cavagnini
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  4. R. Benti
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  5. B. Bareggi
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  6. G. Baccalaro
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  7. G. Basilisco
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Peracchi, M., Carola, F., Cavagnini, F. et al. Plasma somatostatin-like immunoreactivity and somatostatin-28 levels in obese men. J Endocrinol Invest 21, 20–23 (1998). https://doi.org/10.1007/BF03347281

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  • DOI: https://doi.org/10.1007/BF03347281

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