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Metabolic parameters after BioEnterics Intragastric Balloon placement in obese patients

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Abstract

Background: BioEnterics Intragastric Balloon (BIB®) is a non-invasive, temporary and relatively safe procedure shown to be effective in the short-term treatment of obesity. Nowadays, BIB® does not show convincing evidence of significant long-term weight loss, as compared with conventional management, and data regarding changes in metabolic and nutritional parameters are lacking. Methods: Forty obese patients [11 males, 29 females, age 36.65±10.6 yr, body mass index (BMI) 44.9±8.9 kg/m2] were evaluated before and 3 and 6 months after BIB® placement by assessment of anthropometric and biochemical parameters as well as nutritional habits. Results: Patients showed a significant reduction in weight (−13.2±6.5%), BMI (−13.2%), waist circumference (−6.5 cm), and percentage of fat mass (−19.5%), but not fat-free mass. A significant improvement in insulin sensitivity but not in lipid pattern was seen. After BIB® insertion, a significant reduction in caloric intake was paralleled by a redistribution of nutrients; in particular, increased lipid (12.8%) and decreased carbohydrate (−11.7%) percentage, but not absolute intake was observed. Conclusion: These data show that BIB® improves anthropometric parameters, with reduction of fat mass and preservation of fat-free mass, as well as insulin resistance, but not other metabolic features. The observed change in dietary habits, with a relative increase in lipid intake, once BIB® is removed, might favor body weight regain and impact negatively on body weight composition and the other traits of the metabolic syndrome.

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Authors and Affiliations

  1. Endocrinology and Diabetes Unit Department of Medical Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy

    F. Donadio, L. F. Sburlati, B. Masserini, E. M. Lunati, P. Beck-Peccoz & E. Orsi MD

  2. Surgery Unit, Department of Surgery, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy

    E. Lattuada, M. A. Zappa & E. Mozzi

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  1. F. Donadio
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  2. L. F. Sburlati
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  3. B. Masserini
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  4. E. M. Lunati
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  5. E. Lattuada
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  6. M. A. Zappa
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  7. E. Mozzi
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  8. P. Beck-Peccoz
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  9. E. Orsi MD
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Correspondence to E. Orsi MD.

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Donadio, F., Sburlati, L.F., Masserini, B. et al. Metabolic parameters after BioEnterics Intragastric Balloon placement in obese patients. J Endocrinol Invest 32, 165–168 (2009). https://doi.org/10.1007/BF03345708

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