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Inflammatory markers in women with a recent history of gestational diabetes mellitus

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Abstract

Gestational diabetes mellitus (GDM) is a risk factor for both Type 2 diabetes (DM2) and insulin-resistance syndrome (IRS). C-reactive protein (CRP), fibrinogen and leukocyte count are increased in the IRS and predict DM2 and cardiovascular disease (CVD). The chemochine monocyte chemoattractant protein-1 (MCP-1/CCL2) is also elevated in DM2 and CVD. Recent evidence suggests a relation between chronic inflammation and GDM, but post-delivery information on inflammatory markers in these high-risk women is lacking. Serum levels of CRP, fibrinogen, MCP-1/CCL2, and leukocyte blood count have been assessed in 26 women with and 26 women without a recent history of GDM, matched for age, body mass index (BMI), post-partum duration and parity. DM2 was excluded in all the participants by an oral glucose tolerance test (OGTT). Women with previous GDM showed significantly higher CRP (p=0.007) and fibrinogen (p=0.02) serum concentrations, whereas MCP-1/CCL2 serum levels and leukocyte blood count were comparable in the two groups. Overall, CRP levels significantly correlated with BMI (r=0.40, p=0.03), waist-to-hip ratio (WHR) (r=0.44, p=0.001), fasting insulin (r=0.27, p=0.04), insulin-resistance assessed by means of the homeostatic model (HOMA) (r=0.28, p=0.04), and fibrinogen concentration (r=0.49, p=0.0001). At linear regression analysis, only WHR and fibrinogen were independently associated with CRP levels. In conclusion, the increase of inflammatory markers may be one of the first detectable disorders in healthy women at high risk of DM2 and IRS, like those with a GDM history.

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Authors and Affiliations

  1. Department of Internal Medicine, Policlinico Universitario “G. Martino”, Via C. Valeria, 98124, Messina, Italy

    A. Di Benedetto MD, G. T. Russo, E. Di Cesare, E. Alessi & D. Cucinotta

  2. Department of Gynecological Science, University of Messina, Messina, Italy

    F. Corrado & R. D’Anna

  3. Department of Experimental Pathology and Microbiology, University of Messina, Messina, Italy

    G. Nicocia

Authors
  1. A. Di Benedetto MD
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  2. G. T. Russo
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  3. F. Corrado
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  4. E. Di Cesare
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  8. D. Cucinotta
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Correspondence to A. Di Benedetto MD.

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Di Benedetto, A., Russo, G.T., Corrado, F. et al. Inflammatory markers in women with a recent history of gestational diabetes mellitus. J Endocrinol Invest 28, 34–38 (2005). https://doi.org/10.1007/BF03345527

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