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B-type natriuretic peptide in patients with clinical hyperthyroidism

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Abstract

Aims: To investigate the level and clinical significance of plasma B-type natriuretic peptide (BNP) in patients with hyperthyroidism. Methods: Plasma BNP was measured in 32 healthy subjects and 67 patients with clinical hyperthyroidism. Left ventricular anatomy and function was assessed with echocardiography. Results: The average BNP in hyperthyroid patients was higher than that in healthy subjects (186±140 vs 34±17 ng/l, p =0.001). The increase in BNP was mainly found in hyperthyroid patients who had clinical and echocardiographic evidence of left ventricular dysfunction (250±190 ng/l). The BNP level in patients with hyperthyroidism, but with normal left ventricular function, was similar to that of the controls (37±17 vs 34±17, ng/l, p > 0.05). Multi-regression analysis showed that left atrial diameter and left ventricular ejection fraction were independently associated with the plasma levels of BNP. Conclusions: there is a significant elevation in plasma BNP in patients with hyperthyroidism; the increase is largely due to hyperthyroidism-induced left ventricular dysfunction. Measurements of plasma BNP may help to detect heart failure in patients with clinical hyperthyroidism.

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References

  1. Nakamura S, Naruse M, Naruse K, et al. Atrial natriuretic peptide and brain natriuretic peptide coexist in the secretory granules of human cardiac myocytes. Am J Hypertens 1991, 4: 909–12.

    Article  PubMed  CAS  Google Scholar 

  2. Maeda K, Tsutamota T, Wada A, Hisanaga T, Kinoshita M. Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction. Am Heart J 1998, 135: 825–32.

    Article  PubMed  CAS  Google Scholar 

  3. Dao Q, Krishaswamy P, Kazanegra R, et al. Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. J Am Coll Cardiol 2001, 37: 379–85.

    Article  PubMed  CAS  Google Scholar 

  4. Davis M, Epsniner E, Richards G, et al. Plasma brain natriuretic peptide in assessment of acute dyspnoea. Lancet 1994, 343: 440–4.

    Article  PubMed  CAS  Google Scholar 

  5. Cowie MR, Struthers AD, Wood DA, Coats AJ. Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet 1997, 350: 1349–53.

    Article  PubMed  CAS  Google Scholar 

  6. Maisel AS, Krishnaswamy P, Nowak RM, et al. Breathing Not Properly Multinational Study Investigators. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 2002, 347: 161–7.

    Article  PubMed  CAS  Google Scholar 

  7. Wei TM, Zeng CL, Chen LP, et al. Bedside tests of B-type natriuretic peptide in the diagnosis of left ventricular diastolic dysfunction in hypertensive patients. Eur J Heart Fail 2004, (in press).

    Google Scholar 

  8. Klein I. Thyroid hormone and the cardiovascular system. Am J Med 1990, 88: 631–7.

    Article  PubMed  CAS  Google Scholar 

  9. Riaz K, Forker AD, Isley WL, Hamburg MS, McCullough PA. Hyperthyroidism: a “curable” cause of congestive heart failure—three case reports and a review of the literature. Congest Heart Fail 2003, 9: 40–6.

    Article  PubMed  Google Scholar 

  10. Forfar JC, Muir AL, Sawers SA, Toft AD. Abnormal left ventricular function in hyperthyroidism: evidence for a possible reversible cardiomyopathy. N Engl J Med 1982, 307: 1165–70.

    Article  PubMed  CAS  Google Scholar 

  11. Boccalandro C, Boccalandro F, Orlander P, Wei CF. Severe reversible dilated cardiomyopathy and hyperthyroidism: case report and review of the literature. Endocr Pract 2003, 9: 140–6.

    Article  PubMed  Google Scholar 

  12. Kohno M, Horio T, Yasunari K, et al. Stimulation of brain natriuretic peptide release from the heart by thyroid hormone. Metabolism 1993, 42:1059–64.

    Article  PubMed  CAS  Google Scholar 

  13. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 2001, 344: 501–9.

    Article  PubMed  CAS  Google Scholar 

  14. Nordyke RA, Gilbert FI Jr, Harada ASM. Graves’ disease: influence of age on clinical findings. Arch Intern Med 1988, 148: 626–31.

    Article  PubMed  CAS  Google Scholar 

  15. Schultz M, Faber J, Kistorp C, et al. N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) in different thyroid function states. Clin Endocrinol (Oxf) 2004, 60:54–9.

    Article  CAS  Google Scholar 

  16. Silvet H, Young-Xu Y, Walleigh D, Ravid S. Brain natriuretic peptide is elevated in outpatients with atrial fibrillation. Am J Cardiol 2003, 92: 1124–7.

    Article  PubMed  CAS  Google Scholar 

  17. Wozakowska-Kaplon B. Effect of sinus rhythm restoration on plasma brain natriuretic peptide in patients with atrial fibrillation. Am J Cardiol 2003, 93: 1555–8.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Lishui City Central Hospital, Zhejiang Province, the People’s Republic of China

    T. Wei, C. Zeng, Y. Tian & Q. Chen

  2. School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia

    L. Wang MD, PhD

Authors
  1. T. Wei
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  2. C. Zeng
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  3. Y. Tian
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  4. Q. Chen
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  5. L. Wang MD, PhD
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Correspondence to L. Wang MD, PhD.

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Wei, T., Zeng, C., Tian, Y. et al. B-type natriuretic peptide in patients with clinical hyperthyroidism. J Endocrinol Invest 28, 8–11 (2005). https://doi.org/10.1007/BF03345522

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  • DOI: https://doi.org/10.1007/BF03345522

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