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Update on cryptorchidism: Endocrine, environmental and therapeutic aspects

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Abstract

Cryptorchidism is the most frequent developmental abnormality in boys, present in more than 1% of infants above three months of age. It is associated with an increased risk of infertility and testicular cancer. The etiological quest is often disappointing, except in bilateral cases or associated malformations. Recent focus is on genetic and environmental aspects. Animal models have revealed the role of genes encoding for proteins implicated in testicular migration (Insl3, Hoxa 10), but in humans results are less convincing. While some degree of endogenous hormonal abnormality is suspected in some patients, the endocrine disruptor hypothesis is also tested. It is unclear whether the incidence of cryptorchidism has really increased, or whether there is only a better screening for this condition. However, other male reproductive problems, such as subfertility, hypospadias and testicular cancer seem on the rise. This secular trend suggests the possible in utero impact of hormonally active environmental factors, such as pesticides with estrogenic or antiandrogenic effect, and is consistent with the increased risk of cryptorchidism observed in the sons of mothers exposed to diethylstilbestrol during pregnancy. From a therapeutic point of view, there is an agreement that the correction of cryptorchidism is needed, but there is controversy on the best medical and/or surgical approach and on the optimal timing. There is a recent trend in proposing early therapeutic intervention, before 1 yr of age, in the hope of improving fertility; however, there is no proof that such a strategy can reduce the risk of testicular cancer.

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References

  1. Depue R.H. Maternal and gestational factors affecting the risk of cryptorchidism and inguinal hernia. Int. J. Epidemiol. 1984, 13: 311–318.

    PubMed  CAS  Google Scholar 

  2. Hutson J.M., Hasthorpe S., Heyns C.F. Anatomical and functional aspects of testicular descent and cryptorchidism. Endocr. Rev. 1997, 18: 259–280.

    PubMed  CAS  Google Scholar 

  3. Chilvers C., Pike M.C., Forman D., Fogelman K., Wadsworth M.E.J. Apparent doubling of frequency of undescended testis in England and Wales in 1962–1981. Lancet 1984, 2: 330–332.

    PubMed  CAS  Google Scholar 

  4. Jackson M.B. The epidemiology of cryptorchidism. The John Radcliffe Hospital Cryptorchidism Research Group. Horm. Res. 1988, 30: 153–156.

    PubMed  CAS  Google Scholar 

  5. Barone M.A., Roelke M.E., Howard J., Brown J.L., Anderson A.E., Wildt D.E. Reproductive characteristics of male Florida panthers: comparative studies from Florida, Texas, Colorado, Latin America, and North American zoos. J. Mammal. 1994, 75: 150–162.

    Google Scholar 

  6. Dunbar M.R., Cunningham M.W., Wooding J.B., Roth R.P. Cryptorchidism and delayed testicular descent in Florida black bears. J. Wildl. Dis. 1996, 32: 661–664.

    PubMed  CAS  Google Scholar 

  7. Paulozzi L.J. International trends in rates of hypospadias and cryptorchidism. Environ. Health. Perspect. 1999, 107: 297–302.

    PubMed Central  PubMed  CAS  Google Scholar 

  8. Toppari J., Kaleva M., Virtanen H.E. Trends in the incidence of cryptorchidism and hypospadias. Hum. Reprod. Update 2001, 7: 282–286.

    PubMed  CAS  Google Scholar 

  9. Hadziselimovic F. Elevated placental estradiol: a possible etiologic factor of human cryptorchidism. J. Urol. 2000, 164: 1694–1695.

    PubMed  CAS  Google Scholar 

  10. Giwercman A., Carlsen E., Keiding N., Skakkebaek N.E. Evidence of increasing incidence of abnormalities of the human testis: a review. Environ. Health Perspect. 1993, 101: (Suppl 2): 65–71.

    PubMed Central  PubMed  Google Scholar 

  11. Skakkebaek N.E. Trends in male reproductive health. Environmental aspects. In: del Mazo (Ed.), Reproductive Toxicology. Plenum Press, New York, 1998, pp. 1–4.

    Google Scholar 

  12. Adami H-O., Bergström R., Möhner M., et al. Testicular cancer in nine Northern European countries. Int. J. Cancer 1994, 59: 33–38.

    PubMed  CAS  Google Scholar 

  13. Swan S.H., Elkin E.P., Fenster L. Have sperm densities declined? A reanalysis of global trend data. Environ. Health Perspect. 1997, 105: 1228–1232.

    PubMed Central  PubMed  CAS  Google Scholar 

  14. Skakkebaek N.E., Rajpert-de Meyts E., Jorgensen N., et al. Germ cell cancer and disorders of spermatogenesis: an environmental connection? APMIS 1998, 106: 3–12.

    PubMed  CAS  Google Scholar 

  15. Toppari J., Skakkebaek N.E. Sexual differentiation and environmental endocrine disrupters. Baillieres Clin. Endocrinol. Metab. 1998, 12: 143–156.

    PubMed  CAS  Google Scholar 

  16. Skakkebaek N.E., Rajpert-De Meyts E., Main K.M. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum. Reprod. 2001, 16: 972–978.

    PubMed  CAS  Google Scholar 

  17. Gill B., Kogan S. Cryptorchidism. Current concepts. Pediatr. Clin. North Am. 1997, 44: 1211–1227.

    CAS  Google Scholar 

  18. Tanyel F.C., Erdem S., Buyukpamukcu N., Tan E. Cremaster muscles obtained from boys with an undescended testis show significant neurological changes. B.J.U. Int. 2000, 85: 116–119.

    CAS  Google Scholar 

  19. Rey R., Picard J.Y. Embryology and endocrinology of genital development. Baillieres Clin. Endocrinol. Metab. 1998, 12: 17–33.

    PubMed  CAS  Google Scholar 

  20. Noh P.H., Cooper C.S., Snyder H.M. 3rd, et al. Testicular volume does not predict germ cell count in patients with cryptorchidism. J. Urol. 2000, 163: 593–596.

    PubMed  CAS  Google Scholar 

  21. Thong M-K., Lim C-T., Fatimah H. Undescended testes: incidence in 1002 consecutive male infants and outcome at 1 yr of age. Pediatr. Surg. Int. 1998, 13: 37–41.

    PubMed  CAS  Google Scholar 

  22. Bjoro K.J.R., Dybvik T. Congenital abnormalities and growth patterns among cryptorchid boys. Ann. Chir. Gynaecol. 1983, 72: 342–346.

    PubMed  Google Scholar 

  23. Mayr J.M., Lawrenz K., Berghold A. Undescended testicles: an epidemiological review. Acta Paediatr. 1999, 88: 1089–1093.

    PubMed  CAS  Google Scholar 

  24. Rajfer J., Walsh P.C. The existence of intersexuality in patients with hypospadias and cryptorchidism. J. Urol. 1976, 116: 769–770.

    PubMed  CAS  Google Scholar 

  25. Cheng W., Mya G.H., Saing H. Associated anomalies in patients with undescended testes. J. Tropic. Med. 1996, 42: 204–206.

    CAS  Google Scholar 

  26. Hutcheson J.C., Snyder H.M. 3rd, Zuniga Z.V., et al. Ectopic and undescended testes: Two variants of a single congenital anomaly? J. Urol. 2000, 163: 961–963.

    PubMed  CAS  Google Scholar 

  27. Flett M.E., Jones P.F., Youngson G.G. Emerging trends in the management of the impalpable testis. Br. J. Surg. 1999, 86: 1280–1283.

    PubMed  CAS  Google Scholar 

  28. Toppari J., Kaleva M. Maldescendus testis. Horm. Res. 1999, 51: 261–269.

    PubMed  CAS  Google Scholar 

  29. Berkowitz G.S., Lapinski R.H., Dolgin S.E., Gazella J.G., Bodian C.A., Holzman I.R. Prevalence and natural history of cryptorchidism. Pediatrics 1993, 92: 44–49.

    PubMed  CAS  Google Scholar 

  30. Scorer C.G. The descent of the testis. Arch. Dis. Child. 1964, 39: 605.

    PubMed Central  PubMed  CAS  Google Scholar 

  31. John Radcliffe Hospital Cryptorchidism Study Group. Cryptorchidism: an apparent substantial increase since 1960. B.M.J. 1986, 293: 1401–1404.

    Google Scholar 

  32. Moller H., Skakkebaek N.E. Testicular cancer and crytorchidism in relation to prenatal factors: case-control studies in Denmark. Cancer Causes Control 1997, 8: 904–912.

    PubMed  CAS  Google Scholar 

  33. Berkowitz G.S., Lapinski R.H., Godbold J.H., Dolgin S.E., Holzman I.R. Maternal and neonatal risk factors for cryptorchidism. Epidemiology 1995, 6: 127–131.

    PubMed  CAS  Google Scholar 

  34. Akre O., Lipworth., Cnattingius S., Sparen P., Ekbom A. Risk factor patterns for cryptorchidism and hypospadias. Epidemiology 1999, 10: 364–369.

    PubMed  CAS  Google Scholar 

  35. Moller H., Weidner I.S. Epidemiology of cryptorchidism and hypospadias. Epidemiology 1999, 10: 352–354.

    PubMed  CAS  Google Scholar 

  36. Gendrel D., Roger M., Job J-C. Plasma gonadotrophin and testosterone values in infants with cryptorchidism. J. Pediatr. 1980, 97: 217–220.

    PubMed  CAS  Google Scholar 

  37. Job J-C., Toublanc J-E., Chaussain J-L., Gendrel D., Roger M., Canlorbe P. The pituitary-gonadal axis in cryptorchid infants and children. Eur. J. Pediatr. 1987, 146 (Suppl. 2): S2–5.

    PubMed  Google Scholar 

  38. Kubini K., Zachmann M., Albers N., et al. Basal inhibin B and the testosterone response to human chorionic gonadotropin correlate in prepubertal boys. J. Clin. Endocrinol. Metab. 2000, 85: 134–138.

    PubMed  CAS  Google Scholar 

  39. Job J-C., Toublanc J-E., Chaussain J-L., Gendrel D., Roger M. Endocrine and immunological findings in cryptorchid infants. Horm. Res. 1988, 30: 167–172.

    PubMed  CAS  Google Scholar 

  40. Crespo Chozas D., Alonso Blanco M., Yturriaga Matarranz R., Barrio Castellanos R. The evaluation of gonadal function in postpubertal patients treated for cryptorchidism in childhood. An. Esp. Pediatr. 1999, 50: 33–38.

    Google Scholar 

  41. Longui C.A., Arnhold I.J., Mendonca B.B., D’Osvaldo A.F., Bloise W. Serum inhibin levels before and after gonadotropin stimulation in cryptorchid boys under 4 yr of age. J. Pediatr. Endocrinol. Metab. 1998, 11: 687–692.

    PubMed  CAS  Google Scholar 

  42. Gracia J., Sanchez Zalabardo J., Sanchez Garcia J., Garcia C., Ferrandez A. Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood. B.J.U. Int. 2000, 85: 1100–1003.

    CAS  Google Scholar 

  43. Miller K.D., Coughlin M.T., Lee P.A. Fertility after unilateral cryptorchidism. Paternity, time to conception, pretreatment testicular location and size, hormone and sperm parameters. Horm. Res. 2001, 55: 249–253.

    PubMed  CAS  Google Scholar 

  44. Lee P.A., Coughlin M.T. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone and semen data. Horm. Res. 2001, 55: 28–32.

    PubMed  CAS  Google Scholar 

  45. Lee P.A., Coughlin M.T., Bellinger M.F. Inhibin B.: Comparison with indexes of fertility among former cryptorchid and control men. J. Clin. Endocrinol. Metab. 2001: 86: 2576–2584.

    PubMed  CAS  Google Scholar 

  46. Quinton R., Duke V.M., Robertson A., et al. Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization. Clin. Endocrinol. (Oxf.) 2001, 55: 163–174.

    CAS  Google Scholar 

  47. Caron P., Imbeaud S., Bennet A., Plantavid M., Camerino G., Rochiccioli P. Combined hypothalamic-pituitary-gonadal defect in a hypogonadic man with a novel mutation in the DAX-1 gene. J. Clin. Endocrinol. Metab. 1999, 84: 3563–3569.

    PubMed  CAS  Google Scholar 

  48. Wiener J.S., Marcelli M., Gonzales E.T. Jr, Roth D.R., Lamb D.J. Androgen receptor gene alterations are not associated with isolated cryptorchidism. J. Urol. 1998, 160: 863–865.

    PubMed  CAS  Google Scholar 

  49. Bernstein L., Pike M.C., Depue R.H., Ross R.K., Moore J.W., Henderson B.E. Maternal hormonal levels in early gestation of cryptorchid males: a case-control study. Br. J. Cancer 1988, 58: 379–381.

    PubMed Central  PubMed  CAS  Google Scholar 

  50. Yamaguchi T., Kitada S., Osada Y. Chromosomal anomalies in cryptorchidism and hypospadias. Urol. Int. 1991, 47: 60–63.

    PubMed  CAS  Google Scholar 

  51. Kolon T.F., Wiener J.S., Lewitton M., Roth D.R., Gonzales E.T. Jr, Lamb D.J. Analysis of homeobox gene Hoxa-10 mutations in cryptorchidism. J. Urol. 1999, 161: 275–280.

    PubMed  CAS  Google Scholar 

  52. Rijli F.M., Matyas R., Pelligrini M., et al. Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. Proc. Natl. Acad. Sci. USA 1995, 92: 8185–8189.

    PubMed Central  PubMed  CAS  Google Scholar 

  53. Nef S., Parada L.F. Cryptorchidism in mice mutant for Insl3. Nat. Genet. 1999, 22: 295–299.

    PubMed  CAS  Google Scholar 

  54. Zimmermann S., Steding G., Emmen J.M., et al. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 1999, 13: 681–691.

    PubMed  CAS  Google Scholar 

  55. Tomboc M., Lee P.A., Mitwally M.F., et al. Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. J. Clin. Endocrinol. Metab. 2000, 85: 4013–4018.

    PubMed  CAS  Google Scholar 

  56. Baker L.A., Nef S., Nguyen Ronita Stapleton M.T., Pohl H., Parada L.F. The insulin-3 Gene: Lack of a genetic basis for human cryptorchidism. J. Urol. 2002, 167: 2534–2537.

    PubMed  CAS  Google Scholar 

  57. Marin P., Ferlin A., Moro E., Garolla A., Foresta C. Different insulin-like 3 (Insl3) gene mutations not associated with human cryptorchidism. J. Endocrinol. Invest. 2001, 24: RC13–RC15.

    PubMed  CAS  Google Scholar 

  58. Emmen J.M.A., Mcluskey A., Adham I., et al. Involvement of Insulin-like Factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism. Endocrinology 2000, 141: 846–849.

    PubMed  CAS  Google Scholar 

  59. Nef S., Shipman T., Parada L.F. A molecular basis for estrogen-induced cryptorchidism. Dev. Biol. 2000, 224: 354–361.

    PubMed  CAS  Google Scholar 

  60. Gill W.B. Effects on human males of in utero exposure to exogenous sex hormones. In: Mori T. and Nagasawa H. (Eds.), Toxicity of hormones in perinatal life. CRC Press Inc., Boca Raton, 1988, pp. 161–177.

    Google Scholar 

  61. Walker A.H., Bernstein L., Warren D.W., Warner N.E., Zheng X., Henderson B.E. The effect of in utero ethinyl estradiol exposure on the risk of cryptorchid testis and testicular teratoma in mice. Br. J. Cancer. 1990, 62: 599–602.

    PubMed Central  PubMed  CAS  Google Scholar 

  62. Kavlock R.J., Daston G.P., DeRosa C., et al. Research needs for the risk assessment of health and environmental effect of endocrine disruptors: A report of the USEPAsponsored workshop. Environ. Health Perspect. 1996, 104 (Suppl. 4): 715–740.

    PubMed Central  PubMed  Google Scholar 

  63. Colborn T., vom Saal F.S., Soto A.M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 1993, 101: 378–384.

    PubMed Central  PubMed  CAS  Google Scholar 

  64. Oliver Cheek A., Vonier P.M., Oberdôrster E., Collins Burow B.C., McLachlan J.A. Environmental signaling: a biological context for endocrine disruption. Environ. Health Perspect. 1998, 106 (Suppl. 1): 5–10.

    Google Scholar 

  65. Garcia-Rodriguez J., Garcia-Martin M., Nogueras-Ocana M., et al. Exposure to pesticides and cryptorchidism: geographical evidence of a possible association. Environ. Health Perspect. 1996, 104: 1090–1095.

    PubMed Central  PubMed  CAS  Google Scholar 

  66. Restrepo M., Munoz N., Day N., et al. Birth defects among children born to a population occupationally exposed to pesticides in Colombia. Scand. J. Work Environ. Health 1990, 16: 239–246.

    PubMed  CAS  Google Scholar 

  67. Weidner I.S., Moller H., Jensen T.K., Skakkebaek N.E. Cryptorchidism and hypospadias in sons of gardeners and farmers. Environ. Health Perspect. 1998, 106: 793–796.

    PubMed Central  PubMed  CAS  Google Scholar 

  68. Kristensen P., Irgens L.M., Andersen A., Bye A.S., Sundheim L. Birth defects among offspring of Norwegian farmers, 1967–1991. Epidemiology 1997, 8: 537–544.

    PubMed  CAS  Google Scholar 

  69. Garry V.F., Schreinemachers D., Harkins M.E., Griffith J. Pesticide appliers, biocides, and birth defects in rural Minnesota. Environ. Health Perspect. 1996, 104: 394–399.

    PubMed Central  PubMed  CAS  Google Scholar 

  70. Merrigiola M.C., Noonan E.A., Paulsen C.A., Bremner W.J. Annual patterns of luteinizing hormone, follicle stimulating hormone, testosterone and inhibin in normal men. Hum. Reprod. 1996, 11: 248–252.

    Google Scholar 

  71. Foster W., Chan S., Platt L., Hugues C. Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid. J. Clin. Endocrinol. Metab. 2000, 85: 2954–2957.

    PubMed  CAS  Google Scholar 

  72. Saxena M.C., Seth T.D., Mahajan P.L. Organochlorine pesticides in human placenta and accompanying fluid. Int. J. Environ. Anal. Chem. 1980, 7: 245–251.

    PubMed  CAS  Google Scholar 

  73. Burse V.W., Najam A.R., Williams C.C., et al. Utilization of umbilical cords to assess in utero exposure to persistent pesticides and polychlorinated biphenyls. J. Expo. Anal. Environ. Epidemiol. 2000, 10 (Pt2): 776–788.

    PubMed  CAS  Google Scholar 

  74. Rogan W.J. Pollutants in breast milk. Arch. Pediatr. Adolesc. Med. 1996, 150: 981–990.

    PubMed  CAS  Google Scholar 

  75. Olea N., Olea-Serrano F., Lardelli-Claret P., Rivas A., Barba-Navarro A. Inadvertent exposure to xenoestrogens in children. Toxicol. Ind. Health 1999, 15: 151–158.

    PubMed  CAS  Google Scholar 

  76. Kohlmeier L., Kohlmeier M. Adipose tissue as a medium for epidemiologic exposure assessment. Environ. Health Perspect. 1995, 103 (Suppl. 3): 99–106.

    PubMed Central  PubMed  CAS  Google Scholar 

  77. Hosie S., Loff S., Witt K., Niessen K., Waag K.L. Is there a correlation between organochlorine compounds and undescended testes? Eur. J. Pediatr. Surg. 2000, 10: 304–309.

    PubMed  CAS  Google Scholar 

  78. Sohoni P., Sumpter J.P. Several environmental oestrogens are also antiandrogens. J. Endocrinol. 1998, 158: 327–339.

    PubMed  CAS  Google Scholar 

  79. Gray L.E. Jr. Xenoendocrine disrupters: laboratory studies on male reproductive effects. Toxicol. Lett. 1998, 102-103: 331–335.

    PubMed  CAS  Google Scholar 

  80. Gray L.E. Jr, Wolf C., Lambright C., et al. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chozolinate, pp’DDE and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol. Ind. Health 1999, 15: 94–118.

    PubMed  Google Scholar 

  81. Czeizel A.E., Hegedus S., Timar L. Congenital abnormalities and indicators of germinal mutations in the vicinity of an acrylonitrile producing factory. Mutat. Res. 1999, 427: 105–123.

    PubMed  CAS  Google Scholar 

  82. Mylchreest E., Cattley R.C., Foster P.M.D. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl)phthalate. Toxicol. Sci. 1998, 43: 47–60.

    PubMed  CAS  Google Scholar 

  83. Ema M., Miyawaki E., Kawashima K. Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butylphthalate during late pregnancy. Toxicol. Lett. 2000, 111: 271–278.

    PubMed  CAS  Google Scholar 

  84. Husmann D.A., Mcphaul M.J. Time-specific androgen blockade with flutamide inhibits testicular descent in the rat. Endocrinology 1991, 129: 1409–1416.

    PubMed  CAS  Google Scholar 

  85. Mylchreest E., Sar M., Cattley R.C., Foster P.M.D. Disruption of androgen-regulated male reproductive development by di (n-butyl)phthalate during late gestation in rats is different from flutamide. Toxicol. Appl. Pharmacol. 1999, 156: 81–95.

    PubMed  CAS  Google Scholar 

  86. Imajima T., Shono T., Zakaria O., Suita S. Prenatal phthalate causes cryptorchidism postnatally by inducing transabdominal ascent of the testis in fetal rats. J. Pediatr. Surg. 1997, 32: 18–21.

    PubMed  CAS  Google Scholar 

  87. Barthold J.S., Kryger J.V., Derusha A.M., Duel B.P., Jednak R., Skafar D.F. Effects of an environmental endocrine disruptor on fetal development, estrogen receptor (alpha) and epidermal growth factor receptor expression in the porcine male genital tract. J. Urol. 1999, 162: 864–871.

    PubMed  CAS  Google Scholar 

  88. Swerdlow A.J., Higgins C.D., Pike M.C. Risk of testicular cancer in a cohort of boys with cryptorchidism. Br. Med. J. 1997, 315: 1462–1463.

    Google Scholar 

  89. Hadziselimovic F., Herzog B., Hocht B., Hecker E., Miescher E., Buser M. Screening for cryptorchid boys risking sterility and results of long-term buserelin treatment after successful orchiopexy. Eur. J. Pediatr. 1987, 146 (Suppl 2): S59–S62.

    PubMed  Google Scholar 

  90. Huff D.S., Hadziselimovic F., Snyder H.M., et al. Histologic maldevelopment of unilaterally cryptorchid testes and their undescended partners. Eur. J. Pediatr. 1993, 152 (Suppl. 2): S11–S14.

    PubMed  Google Scholar 

  91. Huff D.S., Hadziselimovic F., Snyder H.M. 3rd, Duckett J.W., Keating M.A. Postnatal testicular maldevelopment in unilateral cryptorchidism. J. Urol. 1989, 142: 546–548.

    PubMed  CAS  Google Scholar 

  92. Dieckmann K.P., Skakkebaek N.E. Carcinoma in situ of the testis: review of biological and clinical features. Int. J. Cancer 1999, 83: 815–822.

    PubMed  CAS  Google Scholar 

  93. Hedinger C. Histopathology of the cryptorchid testes. In. Bierich J.R., Giarola A. (Eds.), Cryptorchidism. Academy Press, New York, 1979, p. 29–38.

    Google Scholar 

  94. Kawakami E., Hori T., Tsutsui T. Function of controlateral testis after artificial unilateral cryptorchidism in dogs. J. Vet. Med. Sci. 1999, 61: 1107–1111.

    PubMed  CAS  Google Scholar 

  95. Kogan S.J. Fertility in cryptorchidism. An overview in 1987. Eur. J. Pediatr. 1987, 146 (Suppl. 2): S21–S24.

    PubMed  Google Scholar 

  96. Lee P.A., O’Leary L.A., Songer N.J., Coughlin M.T., Bellinger M.F., LaPorte R.E. Paternity after bilateral cryptorchidism. A controlled study. Arch. Pediatr. Adolesc. Med. 1997, 151: 260–263.

    PubMed  CAS  Google Scholar 

  97. Coughlin M.T., O’leary L.A., Songer N.J., Bellinger M.F., Laporte R.E., Lee P.A. Time to conception after orchidopexy: evidence for subfertility? Fertil. Steril. 1997, 67: 742–746.

    PubMed  CAS  Google Scholar 

  98. Mieusset R., Bujan L., Massat G., Mansat A., Pontonnier F. Clinical and biological characteristics of infertile men with a history of cryptorchidism. Hum. Reprod. 1995, 10: 613–619.

    PubMed  CAS  Google Scholar 

  99. Lee P.A., Coughlin M.T., Bellinger M.F. Paternity and hormone levels after unilateral cryptorchidism: association with pretreatment testicular location. J. Urol. 2000, 164: 1697–1701.

    PubMed  CAS  Google Scholar 

  100. Ludwig G., Potempa J. Optimal time for treating cryptorchidism. Dtsch. Med. Wochenschr. 1975, 100: 680–683.

    PubMed  CAS  Google Scholar 

  101. Engeler D.S., Hosli P.O., Bannwart F., et al. Early orchidopexy: prepubertal intratubular germ cell neoplasia and fertility outcome. Urology 2000, 56: 144–148.

    PubMed  CAS  Google Scholar 

  102. Coughlin M.T., Bellinger M.F., Lee P.A. Age at unilateral orchidopexy: effect on hormone levels and sperm count in adulthood. J. Urol. 1999, 162: 986–988.

    PubMed  CAS  Google Scholar 

  103. Lugg J.A., Penson D.F., Sadeghi F., et al. Prevention of seminiferous tubular atrophy in a naturally cryptorchid rat model by early surgical intervention. J. Androl. 1996, 17: 726–732.

    PubMed  CAS  Google Scholar 

  104. Cortes D., Thorup J.M., Lindenberg S. Fertility potential after unilateral orchidopexy: an age independent risk of subsequent infertility when biopsies at surgery lack germ cells. J. Urol. 1996, 156: 217–220.

    PubMed  CAS  Google Scholar 

  105. Lee A.P., O’Leary L.A., Songer N.J.S., Bellinger M.E., Laporte R.E. Paternity after cryptorchidism: lack of correlation with age at orchidopexy. Br. J. Urol. 1995, 75: 704–707.

    PubMed  CAS  Google Scholar 

  106. Mahmoud A.M., Comhaire F.H., Abdel-Rahim D.E., Abdel-Hafez K.M. Conception rates and assisted reproduction in subfertility due to unilateral cryptorchidism. Andrologia 1996, 28: 141–144.

    PubMed  CAS  Google Scholar 

  107. Sasagawa I., Nakada T., Yanagimachi R. Application of ICSI for cryptorchid therapy. Arch. Androl. 2000, 45: 77–83.

    PubMed  CAS  Google Scholar 

  108. Giwercman A., Grindsted J., Hansen B., Jensen O.M., Skakkebaek N.E. Testicular cancer risk in boys with maldescended testis: A cohort study. J. Urol. 1987, 138: 1214–1216.

    PubMed  CAS  Google Scholar 

  109. Pinczowski D., Mclaughlin J.K., Lackgren G., Adami A.O., Persson I. Occurrence of testicular cancer in patients operated on for cryptorchidism and inguinal hernia. J. Urol. 1991, 146: 1291–1294.

    PubMed  CAS  Google Scholar 

  110. Prener A., Engholm G., Jensen O.M. Genital anomalies and risk for testicular cancer in Danish men. Epidemiology 1996, 7: 14–19.

    PubMed  CAS  Google Scholar 

  111. Giwercman A., Bruun E., Frimodt-Moller C., Skakkebaek N.E. Prevalence of carcinoma in situ and other histopathological abnormalities in testes of men with a history of cryptorchidism. J. Urol. 1989, 142: 998–1001.

    PubMed  CAS  Google Scholar 

  112. Depue R.H., Pike M.C., Henderson B.E. Cryptorchidism and testicular cancer. J. Natl. Cancer Inst. 1986, 77: 830–833.

    PubMed  CAS  Google Scholar 

  113. Martin D.C. Malignancy in the cryptorchid testis. Urol. Clin. North Am. 1982, 9: 371–376.

    PubMed  CAS  Google Scholar 

  114. Pike M.C., Chilvers C., Peckham M.J. Effect of age at orchidopexy on risk of testicular cancer. Lancet 1986, i: 1246–1248.

    Google Scholar 

  115. Moller H., Prener A., Skakkebaek N.E. Testicular cancer, cryptorchidism, inguinal hernia, testicular atrophy and genital malformations: Case-control studies in Denmark. Cancer Causes Control 1996, 7: 264–274.

    PubMed  CAS  Google Scholar 

  116. Pyorala S., Huttunen N.P., Uhari M. A review and metaanalysis of hormonal treatment of cryptorchidism. J. Clin. Endocrinol. Metab. 1995, 80: 2795–2799.

    PubMed  CAS  Google Scholar 

  117. Rajfer J., Handelsman D.J., Swerdloff R.S., et al. Hormonal therapy of cryptorchidism. A randomized, double blind study comparing human chorionic gonadotropin and gonadotropin-releasing hormone. N. Engl. J. Med. 1986, 314: 466–470.

    PubMed  CAS  Google Scholar 

  118. Garagorri J.M., Job J.C., Canlorbe P., Chaussain J.L. Results of early treatment of cryptorchidism with human chorionic gonadotropin. J. Pediatr. 1982, 101: 923–927.

    PubMed  CAS  Google Scholar 

  119. Motta R.G., Botteon S., Mastrogiacomo I. Pulsatile treatment with gonadotrophin-releasing hormone. Minerva Endocrinol. 1990, 15: 79–90.

    PubMed  CAS  Google Scholar 

  120. Bica D.T., Hadziselimovic F. The behavior of epididymis, processus vaginalis and testicular descent in cryptorchid boys treated with Buserelin. Eur. J. Pediatr. 1993, 152 (Suppl.): S38–S42.

    PubMed  Google Scholar 

  121. Hadziselimovic F., Herzog B. Treatment with luteinizing hormone-releasing hormone analogue after successful orchidopexy markedly improves the chance of fertility later in life. J. Urol. 1997, 158: 1193–1395.

    PubMed  CAS  Google Scholar 

  122. Bica D.T., Hadziselimovic F. Buserelin treatment of cryptorchidism. A randomized, double blind, placebo-controlled study. J. Urol. 1992, 148: 617–621.

    PubMed  CAS  Google Scholar 

  123. Huff D.S., Snyder H.M. 3rd, Rusnack S.L., Zderic S.A., Carr M.C., Canning D.A. Hormonal therapy for the subfertility of cryptorchidism. Horm. Res. 2001, 55: 38–40.

    PubMed  CAS  Google Scholar 

  124. Matthews L.A., Abdul-Karim F.W., Elder J.S. Effect of preoperative chorionic gonadotropin on intraabdominal testes undergoing standard and Fowler-Stephens orchidopexy. J. Urol. 1997, 157: 2315–2317.

    PubMed  CAS  Google Scholar 

  125. Dunkel L., Taskinen S., Hovatta O., Tilly J.L., Wilkstrom S. Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J. Clin. Invest. 1997, 100: 2341–2346.

    PubMed Central  PubMed  CAS  Google Scholar 

  126. Cortes D., Thorup J., Visfeldt J. Hormonal treatment may harm the germ cells in 1 to 3-yr old boys with cryptorchidism. J. Urol. 2000, 163: 1290–1292.

    PubMed  CAS  Google Scholar 

  127. Demirbilek S., Atayurt H.F., Celik N., Aydin G. Does treatment with human chorionic gonadotropin induce reversible changes in undescended testes in boys? Pediatr. Surg. Int. 1997, 12: 591–594.

    PubMed  CAS  Google Scholar 

  128. Kaleva M., Arsolo A., Louhimo I., et al. Treatment with human chorionic gonadotrophin for cryptorchidism: clinical and histological effects. Int. J. Androl. 1996, 19: 293–298.

    PubMed  CAS  Google Scholar 

  129. Docimo S.G. The results of surgical therapy for cryptorchidism: A literature review and analysis. J. Urol. 1995, 154: 1148–1152.

    PubMed  CAS  Google Scholar 

  130. Cortes D., Thorup J.M., Visfeldt J. Cryptorchidism: Aspects of fertility and neoplasms. A study including data of 1335 consecutive boys who underwent test biopsy simultaneously with surgery for cryptorchidism. Horm. Res. 2001, 55: 21–27.

    PubMed  CAS  Google Scholar 

  131. American Academy of Pediatrics. Timing of elective surgery on the genitalia of male children with particular reference to the risks, benefits, and psychological effects of surgery and anesthesia. Pediatrics 1996, 97: 590–594.

    Google Scholar 

  132. Kogan S.J., Tennenbaum S., Gill B., Reda E., Levitt S.B. Efficacy of orchidopexy by patient age one yr for cryptorchidism. J. Urol. 1990, 144: 508–509.

    PubMed  CAS  Google Scholar 

  133. Canavese F., Cortese M.G., Magro P., et al. Cryptorchidism: medical and surgical treatment in the first yr of life. Pediatr. Surg. Int. 1998, 14: 2–5.

    PubMed  CAS  Google Scholar 

  134. Bukowski T.P., Wacksman J., Billmire D.A., Lewis A.G., Sheldon C.A. Testicular autotransplantation: A 17-yr review of an effective approach to the management of intraabdominal testis. J. Urol. 1995, 154: 558–561.

    PubMed  CAS  Google Scholar 

  135. Turek P.J., Ewalt D.H., Snyder H.M. 3rd, et al. The absent cryptorchid testis: surgical findings and their implications for diagnosis and etiology. J. Urol. 1994, 151: 718–720.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Service d’Endocrinologie, Hôpital l’Archet 1, Centre Hospitalier Universitaire de Nice, 151 route de Saint-Antoine, BP 79, 06202, Nice, Cedex 3, France

    Françoise Brucker-Davis & P. Fenichel

  2. Service d’Urologie, Hôpital Pasteur, Nice, France

    D. Chevallier

  3. INSERM, EMI 00-09, Faculté de Médecine, Nice, France

    Françoise Brucker-Davis, G. Pointis, D. Chevallier & P. Fenichel

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  1. Françoise Brucker-Davis
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  2. G. Pointis
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  4. P. Fenichel
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Correspondence to Françoise Brucker-Davis.

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Brucker-Davis, F., Pointis, G., Chevallier, D. et al. Update on cryptorchidism: Endocrine, environmental and therapeutic aspects. J Endocrinol Invest 26, 575–587 (2003). https://doi.org/10.1007/BF03345224

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