Abstract
The aim of this study was to analyze and compare clinico pathological aspects of Riedel’s thyroiditis (RT) and the fibrous variant of Hashimoto’s thyroiditis (HTFV), and to show their immunohistochemical features. We reviewed 6 cases of HTFV and 4 cases of RT. Compared to RT, HTFV patients had hypothyroidism, no pressure symptoms, and frequently diagnostic fineneedle aspiration biopsy (FNAB) cytology. At histology, invasion of surrounding tissues and presence of occlusive phlebitis distinguished RT from HTFV. At immunohistochemistry, RT — compared to HTVF — was characterized by: 1) a more abundant fibrous reaction, and granulocytic, monocytic and eosinophil infiltration; 2) few plasmacells, CD8+ T- and B-lymphocytes. The results of our study add further evidence regarding the separation of RT and HTFV in their peculiar clinical, laboratory, cyto-histological and immunohistochemical aspects.
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Malotte M.J., Chonkich G.D., Zuppan C.W. Riedel’s thyroiditis. Arch. Otolaryngol. Head Neck Surg. 1991, 117: 214–217.
Vitti P., Rago T., Barbesino G., et al. Thyroiditis: clinical aspects and diagnostic imaging. Rays 1999, 24: 301–314.
Li Volsi V.A. Surgical pathology of the thyroid. W.B. Saunders, Philadelphia, 1990, 245–267.
Katz S.M., Vichery A.L. The fibrous variant of Hashimoto’s thyroiditis. Hum. Pathol. 1974, 5: 161–170.
Heufelder A.E., Goellner J.R., Bahn R.S., et al. Tissue eosinophilia and eosinophil degranulation in Riedel’s invasive fibrous thyroiditis. J. Clin. Endocrinol. Metab. 1996, 81: 977–984.
Ewing J. Neoplastic disease. 3th ed. W.B. Saunders, Philadelphia, 1928, p. 961.
Woolner L.B., McConahey W.M., Beahrs O.H. Invasive fibrous thyroiditis (Riedel’s struma). J. Clin. Endocrinol. Metab. 1957, 17: 201–220.
Meijer S., Hausman R. Occlusive phlebitis, a diagnostic feature in Riedel’s thyroiditis. Virchows Arch. Pathol. A. Histol. 1978, 377: 339–349.
Gooding G.A.W., Higgins C.B. Sonography of the thyroid and parathyroid. Radiol. Clin. North Am. 1993, 9: 975–979.
De May R.M. Riedel’s thyroiditis. In: The art and science of cytopathology. Aspiration cytology. ASCP Press, Chicago, 1996, 721–722.
Papi G., Corrado S., Cesinaro A.M., et al. Riedel thyroiditis: clinical, pathological and imaging features. Int. J. Clin. Pract. 2002, 56: 65–67.
Taunberger J.K., Merino Maria J., Medeiros L.J. A thyroid biopsy with histologic features of both Riedel’s thyroiditis and the fibrous variant of Hashimoto’s thyroiditis. Hum. Pathol. 1992, 23: 1072–1075.
Zelmanovitz F., Zelmanovitz T., Beck M., Cerski C.T., Schmid H., Czepielewski M.A. Riedel’s thyroiditis associated with high titers of antimicrosomal and antithyroglobulin antibodies and hypothyroidism. J. Endocrinol. Invest. 1994, 17: 733–737.
Jukie C., Vieillefond A., Desligneres S., Schaison G., Grunfeld J.P., Franc B. Hashimoto’s thyroiditis associated with Riedel’s thyroiditis and retroperitoneal fibrosis. Pathol. Res. Pract. 1997, 193: 573–577.
Baloch Z.W., Saberi M., LiVolsi V.A. Simultaneous involvement of thyroid by Riedel’s disease and fibrosing Hashimoto’s thyroiditis: a case report. Thyroid 1998, 8: 337–341.
Baloch Z.W., Feldman M.D., LiVolsi V.A. Combined Riedel’s disease and fibrosing Hashimoto’s thyroiditis: a report of three cases with two showing coexisting papillary carcinoma. Endocr. Pathol. 2000, 11: 157–167.
Harach H.R., Williams E.D. Fibrous thyroiditis — an immunopathological study. Histopathology 1983, 7: 739–751.
Weetman A.P., McGregor A.M. Autoimmune thyroid disease: further developments in our understanding. Endocr. Rev. 1994, 15: 788–830.
Iitaka M., Aguayo J..F, Iwatani Y., et al. Studies of the effect of suppressor T lymphocytes on the induction of antithyroid microsomal antibody-secreting cells in autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 1988, 66: 708–714.
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Papi, G., Corrado, S., Carapezzi, C. et al. Riedel’s thyroiditis and fibrous variant of Hashimoto’s thyroiditis: A clinicopathological and immunohistochemical study. J Endocrinol Invest 26, 444–449 (2003). https://doi.org/10.1007/BF03345200
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DOI: https://doi.org/10.1007/BF03345200