Abstract
The aim of this research was to establish the importance of calcium intake through mineral water on vertebral bone density in women. To this purpose, we examined 255 women divided into two groups: those regularly drinking a high calcium content mineral water (group A; no.=175) and those using different type of water with a lower calcium content (group B; no.=80). Their dietary daily calcium intake was determined by means of a validated questionnaire (N.I.H. Consensus statement) and vertebral bone density was measured by Dual-Energy X-ray absorptiometry (Unigamma-plus ACN densitometer). Women in group A ingested a significantly higher quantity of calcium in water than women in group B (mean difference 258 mg; 95% confidence limits: 147-370 mg). The average bone density values were slightly but significantly higher in group A as compared to group B (mean±SD: 1.044+0,15 vs 1.002+0,14; p=0.03). In addition to age, BMI and menopausal status, calcium intake was a significant predictor of spinal BMD. These 4 variables explained about 35% of the spinal BMD variance. When the analysis was repeated separately for pre- and post-menopausal subjects, calcium remained a significant predictor in post-menopausal women (t=2.28; p=0.02), but not in premenopausal women. These results underline the importance of a lifelong daily calcium intake, resulting by the regular drinking of high bioavailable calcium water, in order to maintain bone mass after the menopause, in comparison to the use of a lower content calcium water.
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References
N.I.H. Consensus Conference 1994, 12: 4, 1–31.
Nordin B.E.C., Heaney R.P. Calcium supplementation of diet: justified by present evidence. Br. Med. J. 1990, 300: 1056–1059.
Passeri M., Passeri G. Le osteopatie senili In: G. Crepaldi, (Ed.), Trattato di Gerontologia e Geriatria, UTET, Torino, 1992, p. 839–864.
Couzy F., Kastenmayer P., Vigo M., Clough J., Munoz-Box R., Barclay D.V. Calcium bioavailability from a calcium- and sulfaterich mineral water, compared with milk, in young adult women. Am. J. Clin. Nutr. 1995, 62: 1239–1245.
Peterson C.A., Evrell J.A.C., Erdmand J.W.J. Alterations in calcium intake on peak bone mass in female rat. J. Bone Miner. Res. 1995, 10: 1, 81–95.
Blumson A., Herrington K., Hannon R.A., Shao P., Eyre D.R., Eastell R. The effect of calcium supplementation on the circadian rhythm of bone resorption. J. Clin. Endocrinol. Metab. 1994, 79: 730–734.
Heaney R.P., Recker R.R., Saville P.D. Calcium balance and calcium requirement in middleaged women. Am. J. Clin. Nutr. 1977, 30: 1603–1608.
Johnston C.C., Miller J.Z., Slemenda C.W., Reister T.K., Hui S., Christian J.C., Peacock M. Calcium supplementation and increases in bone mineral density in children. N. Engl. J. Med. 1992, 327: 82–87.
Nellans H.N. Intestinal calcium absorption. Miner. Electrolyte Metab. 1990, 16: 101–108.
Elders P.J.M., Netelenbos J.C., Lips P., Van Ginkel F.C., Khoe E., Leeuwenkamp O.R., Hackeng W.H.L., Van den Slelt P.F. Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age. J. Clin. Endocrinol. Metabol. 1991, 73: 533–540.
Recker R.R., Saville P.D., Heaney R.P. Effects of estrogens and calcium carbonate on bone loss in postmenopausal women. Ann. Intern. Med. 1977, 87: 649–655.
Reid I.R., Armes R.W., Evans M.C., Gamble G.D., Sharpe S.J. Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial. Am. J. Med. 1995, 98: 331–337.
Riggs B.L., Wahner H.W., Melton L.J. III, Richelson L.S., Judd H.L., O’Fallon W.M. Dietary calcium intake and rates of bone loss in women. J. Clin. Invest. 1987, 80: 979–982.
Riis B., Thomsen K., Christiansen C. Does calcium supplementation prevent postmenopausal bone loss? A double-blind controlled clinical study. N. Engl. J. Med. 1985, 316: 173–177.
Matkovic V., Kostial K., Simonovic I., Buzina R., Brodarec A., Nordin B.E.C. Bone status and fracture rates in two regions of Yugoslavia. Am. J. Clin. Nutr. 1979, 32: 540–549.
Heaney R.P., Dowell M.S. Absorbability of calcium in a high-calcium mineral water. Osteoporosis Int. 1994, 4: 323–324.
Albanese A.A., Edelson A.H., Lorenze E.J., Woodhull M.L., Wein E.H. Problems of bone health in elderly. N Y State J. Med. 1975, 75: 326–336.
Lamke B., Sjoberg H.E., Sylven M. Bone mineral content in women with Colles’ fracture: effect of calcium supplementation. Acta Orthop. Scand. 1978, 49: 143–147.
Sheikh M.S., Schiller L.R., Fordtran J.S. In vivo intestinal absorption of calcium in humans. Miner. Electrolyte Metab. 1990, 16: 130–146.
Baran D., Sorensen A., Grimes J., Lew R., Karellas A., Johnson B., Roche J. Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: a three-year prospective study. J. Clin. Endocrinol. Metab. 1990, 70: 264–270.
Johnell O., Gullberg B., Kanis J.A., Allander E., Elffors L., Dequeker J., Dilsen G., Gennari C., Lopes Vaz A., Lyritis G., Mazzuoli G., Miravet L., Passeri M., Perez Cano R., Rapado A., Ribot C. Risk factors for hip fracture in European women: the Medos study. J. Bone Miner. Res. 1995, 10: 1802–1809.
Cepollaro C., Orlandi G., Gonnelli S., Arditti J.C., Borracelli D., Toti E., Gennari C. Effect of calcium supplementation as a high calcium mineral water on bone loss in early post-menopausal women. Calcif. Tissue Int. 1966, 59: 238–239.
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Costi, D., Calcaterra, P.G., Iori, N. et al. Importance of bioavailable calcium drinking water for the maintenance of bone mass in post-menopausal women. J Endocrinol Invest 22, 852–856 (1999). https://doi.org/10.1007/BF03343658
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DOI: https://doi.org/10.1007/BF03343658