Abstract
The menopause transition period, extending from active reproductive capacity with well-characterized hormone profiles through reproductive senescence, has been less well studied than any other period of the life span except extreme old age. Yet, for the gerontologist, this is an important period to understand for at least two reasons. First, during this period changes in the neuroendocrine system and ovary may provide a model for the study of other aging-related processes. Second, specific characteristics of this transitional period (including duration, intensity, and age at menopause) may be considered “aging”, and influence short-term health and quality-of-life status, as well as life expectancy. In addition to discussing the menopause transition in terms of age and culture, we include some of the theories and conceptual models that can influence the nature and interpretation of information from this time period, and its ultimate impact on health and health practice.
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References
World Health Organization: Report of a WHO Scientific Group. Research on the menopause. WHO Technical report series 670. Geneva, 1981.
Prior J.C.: Perimenopause: The complex endocrinology of the menopausal transition. Endocr. Rev. 19: 397–498, 1998.
Metcalf M.G., Donald R.A., Livesey J.H.: Pituitary-ovarian function before, during and after the menopause: A longitudinal study. Clin. Endocrinol. (Oxf.) 17: 489–494, 1982.
van Look P.F., Lothian H., Hunter W.M., Michie E.A., Baird D.T.: Hypothalamic-pituitary-ovarian function in perimenopausal women. Clin. Endocrinol. (Oxf.) 7: 13–31, 1977.
Reyes F.I., Winter J.S.D., Faiman C.: Pituitary-ovarian relationships preceding the menopause. Am. J. Obstet. Gynecol. 129: 557–564, 1977.
Santoro N., Brown J.R., Adel T., Skurnick J.H.: Characterization of reproductive hormonal dynamics in the perimenopause. J. Clin. Endocrinol. Metab. 81: 1495–1501, 1996.
Shideler S.E., DeVane G.W., Kaira P.S., Benirschke K., Lasley B.L.: Ovarian-pituitary hormone interactions during the perimenopause. Maturitas 11: 331–339, 1989.
Klein N.A., Battaglia D.E., Mille P.B., Branigan E.F., Giudice L.C., Soules M.R.: Ovarian follicular development and the follicular fluid hormones and growth factors in normal women of advanced reproductive age. J. Clin. Endocrinol. Metab. 81: 1946–1951, 1996.
Metcalf M.G.: Incidence of ovulatory cycles in women approaching the menopause. J. Biosoc. Sci. 11: 39–48, 1979.
Reame N.E., Kelch R.P., Beitins I.Z., Zawacki C.M., Padmanabhan V.: Age effects of FSH and pulsatile LH secretion across the menstrual cycles of premenopausal women. J. Clin. Endocrinol. Metab. 81: 1512–1518, 1996.
Vagenakis A.G.: Endocrine aspects of menopause. Clin. Rheumatol. 8: 48–51, 1989.
Treloar A.E., Boynton R.E., Behn B.G., Brown B.W.: Variation of the human menstrual cycle through reproductive life. Int. J. Fertil. 12: 77–127, 1967.
Vollman R.F.: The menstrual cycle. Major problems in obste-trics and gynecology, Vol. 7, WB Saunders, Philadelphia, 1977.
Rutherford A.M.: The menopause. N. Z. Med. J. 87: 251–253, 1978.
Chakravarti S., Collins W.P., Forecast J.D., Newton J.R., Oram D.H., Studd J.W.W.: Hormonal profiles after the menopause. BMJ 2: 784–787, 1976.
Scaglia H., Medina M., Pinto-Ferreira A.L, Vazques G., Gual C., Perez-Palacios G.: Pituitary LH and FSH secretion and responsiveness in women of old age. Acta Endocrinol. (Copenh.) 81: 673–679, 1976.
Baird D.T., Guevara A.: Concentration of unconjugated estrone and estradiol in peripheral plasma in non-pregnant women throughout the menstrual cycle, castrate and postmenopausal women and men. J. Clin. Endocrinol. Metab. 29: 149–156, 1969.
Longcope G.: Metabolic clearance rates and blood production rates of estrogens in postmenopausal women. Am. J. Obstet. Gynecol. 111: 778–781, 1971.
Longcope C., Franz C., Morello C., Baker R., Johnston C.C. Jr.: Steroid and gonadotropin levels in women during the peri-menopausal years. Maturitas 8: 189–196, 1986.
Sowers M.F., Crutchfield M., Bandekar R., Randolph J.F., Shapiro B., Schork M.A., Jannausch M.: Bone mineral density and its change in pre and perimenopausal white women: the Michigan Bone Health Study. J. Bone Miner. Res. 13: 1134–1140, 1998.
Sowers M.F., Crawford S., Sternfeld B., Morgenstein D., Gold E., Greendale G., Evans D., Neer R., Matthews K., Sherman S., Lo A., Weiss G., Kelsey J.: SWAN: A multi-center, multi-ethnic, community-based cohort study of women and the menopausal transition. (in press).
Hunter M.: The South-East England longitudinal study of the climacteric and postmenopause. Maturitas 14: 117–126, 1992.
Metcalf M.G., Livesey J.H.: Gonadotropin excretion in fertile women: effect of age and the onset of the menopausal transition. J. Endocrinol. 105: 357–362, 1985.
Longcope C.: Hormone dynamics at the menopause. Ann. N.Y. Acad. Sci. 592: 21–30, 1990.
Flint M.P.: Secular trends in menopause age. J. Psychosom. Obstet. Gynecol. 18: 65–72, 1997.
Scragg R.F.R.: Menopause and reproductive span in rural Niu-gini. In: Proceedings of the Annual Symposium of the Papua New Guinea Medical Society, Port Moresby, 1973, pp. 126–144.
Mattison D.R., Thorgeirsson S.S.: Smoking and industrial pollution, and their effects on menopause and ovarian cancer. Lancet 1: 187–188, 1978.
Baron J.A.: Smoking and estrogen-related disease. Am. J. Epidemiol. 119: 9–22, 1984.
Lindquist O., Bengtsson C.: The effect of smoking on menopausal age. Maturitas 1: 191–199, 1979.
Jick H., Porter J.: Relation between smoking and age of natural menopause. Lancet ii:1354–1355, 1977.
Andersen F.S., Transbol I., Christiansen C.: Is cigarette smoking a promoter of the menopause? Acta Med. Scand. 212: 137–139, 1982.
Adena M.A., Gallagher H.G.: Cigarette smoking and the age at menopause. Ann. Hum. Biol. 9: 121–130, 1982.
McKinlay S.M., Bifano N.L., McKinlay J.B.: Smoking and age at menopause in women. Ann. Intern. Med. 103: 350–356, 1985.
Brambilla D.J., McKinlay S.M.: A prospective study of factors affecting age at menopause. J. Clin. Epidemiol. 42: 1031–1039, 1989.
Willet W., Stampfer M.J., Bain C., Lipnick R., Speizer F.E., Rosner B., Cramer D., Hennekens C.H.: Cigarette smoking, relative weight, and menopause. Am. J. Epidemiol. 117: 651–658, 1983.
Whelan E.A., Sandler D.P., McConnaughey D.R., Weinberg C.R.: Menstrual and reproductive characteristics and age at natural menopause. Am. J. Epidemiol. 131: 625–632, 1990.
Garrido-Latorre F., Lazcano-Ponce E.C., Lopez-Carrillo L., Hernandez-Avila M.: Age of natural menopause among women in Mexico City. Int. J. Gynaecol. Obstet. 53: 159–166, 1996.
MacMahon B., Worcester J.: Age at menopause, United States 1960–1962. National Center for Health Statistics, Rockville, MD. Vital and health statistics, series 11, no. 19, 1966.
Brand P.C., Lehert P.H.: A new way of looking at environmental variables that may affect the age at menopause. Maturitas 1: 121–132, 1978.
Torgerson D.J., Thomas R.E., Campbell M.K., Reid D.M.: Alcohol consumption and age of maternal menopause are associated with menopause onset. Maturitas 26: 21–25, 1997.
Khaw K.T.: Epidemiology of the menopause. BMJ 48: 249–261, 1992.
Michnovicz J.J., Hershcopf R.J., Naganuma H., Bradlow H.L., Fishman J.: Increased 2-hydroxilation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N. Engl. J. Med. 315: 1151–1154, 1986.
Longcope C., Johnston C.C.: Androgen and estrogen dynamics in pre- and postmenopausal women: a comparison between smokers and nonsmokers. J. Clin. Endocrinol. Metab. 67: 379–383, 1988.
Richardson S.J., Nelson J.F.: Follicular depletion during the menopausal transition. Ann. N.Y. Acad. Sci. 592: 13–20, 1990.
Cresswell J.L., Egger P., Fall C.H.D., Osmond C., Fraser R.B., Barker D.J.P.: Is the age of menopause determined in-utero? Early Hum. Dev. 49: 143–148, 1997.
Snowdon D.A., Kane R.L., Beeson W.L., Burke G.L., Sprafka J.M., Potter J., Iso H., Jacobs D.R., Phillips R.L.: Is early natural menopause a biologic marker of health and aging? Am. J. Public Health 79: 709–714, 1989.
Cooper C., Inskip H., Croft P., Campbell L., Smith G., McLaren M., Coggon D.: Individual risk factors for hip osteoarthritis: obesity, hip injury, and physical activity. Am. J. Epidemiol. 147: 516–522, 1998.
Gardsell P., Johnell O., Nilsson B.E.: The impact of menopausal age on future fragility fracture risk. J. Bone Miner. Res. 6: 429–433, 1991.
Matthews K.A., Wing R.R., Kuller L.H., Meilahn E.N., Plantinga P.: Influence of the peri-menopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch. Intern. Med. 154: 2349–2355, 1994.
McKinlay S.M., Brambilla D.J., Posner J.G.: The normal menopause transition. Maturitas 14: 103–115, 1992.
Neugarten B.L., Kraines R.J.: Menopausal symptoms in women of various ages. Psychosom. Med. 27: 266–273, 1965.
Thompson B., Hart S.A., Durno D.: Menopausal age and symptomatology in a general practice. J. Biosoc. Sci. 5: 71–82, 1973.
McKinlay S.M., Jefferys M.: The menopausal syndrome. Br. J. Prev. Soc. Med. 28: 108–115, 1974.
Boulet M.: The menopause and the climacteric in seven Asian countries. Six International Congress on the Menopause, Parthenon, New Jersey, 1990.
Chompootweep S., Tankeyoon M., Yamarat K., Poomsuwan P., Dusitsin N.: The menopausal age and climacteric complaints in Thai women in Bangkok. Maturitas 17: 63–71, 1993.
Goodman M.J., Stewart C.J., Gilbert F.: Patterns of menopause: a study of certain medical and physiological variables among Caucasian and Japanese women living in Hawaii. J. Gerontol. 32: 291–298, 1977.
Holte A.: Influences of natural menopause on health complaints: A prospective study of healthy Norwegian women. Maturitas 14: 127–141, 1992.
Beyene Y.: Cultural significance and physiological manifestations of menopause. A biocultural analysis. Cult. Med. Psychiatry 10: 47–71, 1986.
Erlik Y., Meldrum D.R., Judd H.L.: Estrogen levels in postmenopausal women with hot flashes. Obstet. Gynecol. 59: 403–407, 1982.
Kato I., Toniolo P., Akhmedkhanov A., Koenig K., Shore R., Zeleniuch-Jacquotte A.: Prospective study of factors influencing the onset of natural menopause. J. Clin. Epidemiol. 51: 1271–1276, 1998.
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Sowers, M.F.R. The menopause transition and the aging process: A population perspective. Aging Clin Exp Res 12, 85–92 (2000). https://doi.org/10.1007/BF03339895
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DOI: https://doi.org/10.1007/BF03339895