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Immunological and immunogenetic markers in sporadic Alzheimer’s disease

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Abstract

Background: Common polymorphisms of genes controlling inflammation-modulating cytokines and acute-phase proteins which play important roles in the pathogenesis of Alzheimer’s disease (AD) have been shown to be associated with AD. Aims: The immunological and immunogenetic markers potentially useful for the AD risk evaluation and diagnosis are briefly reviewed. Conclusion: The state-of-the-art of immunological and immunogenetic markers of AD indicates that new tools and strategies are necessary to identify gene products useful as diagnostic tools.

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References

  1. Nussbaum RL, Ellis CE. Alzheimer’s disease and Parkinson’s disease. N Engl J Med 2003; 348: 1356–64.

    Article  PubMed  CAS  Google Scholar 

  2. Consensus report of the working group on: Molecular and biochemical markers of Alzheimer’s disease. Neurobiol Aging 1998; 19: 109–16.

    Google Scholar 

  3. Teunissen CE, de Vente J, Steinbusch HW, et al. Biochemical markers related to Alzheimer’s dementia in serum and cerebrospinal fluid. Neurobiol Aging 2002; 23: 485–508.

    Article  PubMed  CAS  Google Scholar 

  4. in t’Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease. N Engl J Med 2001; 345: 1515–21.

    Article  Google Scholar 

  5. Licastro F, Chiappelli M. Brain immune responses cognitive decline and dementia: relationship with phenotype expression and genetic background. Mech Ageing Dev 2003; 124: 539–48.

    Article  PubMed  CAS  Google Scholar 

  6. Lio D, Licastro F, Scola L, et al. Interleukin-10 promoter polymorphism in sporadic Alzheimer’s disease. Genes Immun 2003; 4: 234–8.

    Article  PubMed  CAS  Google Scholar 

  7. Franceschi C, Valensin S, Lescai F, et al. Neuroinflammation and the genetics of Alzheimer’s disease: The search for a pro-inflammatory phenotype. Aging Clin Exp Res 2001; 13: 163–70.

    CAS  Google Scholar 

  8. Lee YB, Nagai A, Kim SU. Cytokines, chemokines, and cytokine receptors in human microglia. J Neurosci Res 2002; 69: 94–103.

    Article  PubMed  CAS  Google Scholar 

  9. Licastro F, Candore G, Lio D, et al. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2005; 2: 8–23.

    Article  PubMed  Google Scholar 

  10. Candore G, Balistreri CR, Colonna-Romano G, Lio D, Caruso C. Major histocompatibility complex and sporadic Alzheimer’s disease: a critical reappraisal. Exp Gerontol 2004; 39: 643–50.

    Article  Google Scholar 

  11. Combarros O, Llorca J, Sanchez-Guerra M, Infante J, Berciano J. Age-dependent association between interleukin-1A (-889) genetic polymorphism and sporadic Alzheimer’s disease. A metaanalysis. J Neurol 2003; 250: 987–9.

    Article  CAS  Google Scholar 

  12. Grimaldi LM, Casadei VM, Ferri C, et al. Association of early-onset Alzheimer’s disease with an interleukin-1alpha gene polymorphism. Ann Neurol 2000; 47: 361–5.

    Article  PubMed  CAS  Google Scholar 

  13. Li R, Yang L, Lindholm K, et al. Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death. J Neurosci 2004; 24: 1760–71.

    Article  PubMed  CAS  Google Scholar 

  14. Uberti D, Cantarella G, Facchetti F, et al. TRAIL is expressed in the brain cells of Alzheimer’s disease patients. Neuroreport 2004; 15: 579–81.

    Article  PubMed  CAS  Google Scholar 

  15. Caruso C, Franceschi C, Licastro F. Genetics of neurodegener-ative disorders. N Engl J Med 2003; 349: 193–4 (Letter).

    Article  PubMed  Google Scholar 

  16. Lio D, Caruso C. IL-10, Genetic polymorphism and its relevance to age-related diseases. In Marincola FM, ed. Interleukin 10. Eurekah.com 2004; 3.4: 1–14.

    Google Scholar 

  17. Caruso C, Candore G, Colonna-Romano G, Lio D, Franceschi C. Inflammation and life-span. Science 2005; 307: 208–9 (Letter).

    Article  PubMed  CAS  Google Scholar 

  18. Neale BM, Sham PC. The future of association studies: gene-based analysis and replication. Am J Hum Genet 2004; 75: 353–62.

    Article  PubMed  CAS  Google Scholar 

  19. Zhang R, Barker L, Pinchev D, et al. Mining biomarkers in human sera using proteomic tools. Proteomics 2004; 4: 244–56.

    Article  PubMed  CAS  Google Scholar 

  20. Cagnin A, Brooks DJ, Kennedy AM, et al. In-vivo measurement of activated microglia in dementia. Lancet 2001; 358: 461–7.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Patologia Clinica, Gruppo di Studio sull’Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, C.so Tukory 211, I-90134, Palermo, Italy

    Domenico Lio, Letizia Scola, Giuseppina Colonna Romano, Giuseppina Candore & Calogero Caruso

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  1. Domenico Lio
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  2. Letizia Scola
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  3. Giuseppina Colonna Romano
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  4. Giuseppina Candore
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  5. Calogero Caruso
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Corresponding author

Correspondence to Domenico Lio.

Additional information

This work was presented at the “International Meeting — The Aging People”, Pavia, 2–4 September 2004.

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Lio, D., Scola, L., Romano, G.C. et al. Immunological and immunogenetic markers in sporadic Alzheimer’s disease. Aging Clin Exp Res 18, 163–166 (2006). https://doi.org/10.1007/BF03327434

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  • DOI: https://doi.org/10.1007/BF03327434

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