Summary
In 4 studies involving 1048 patients with major depression, the effects of therapeutic doses of sertraline on the electrocardiogram (ECG) were compared with those of placebo and amitriptyline. ECG tracings before and at the end of 4 randomised double-blind clinical trials were evaluated without knowledge of the study medication to which patients had been assigned. In each treatment group, mean changes in heart rate and RR, PR, QRS and QT intervals were assessed, as was the incidence of changes in various ECG parameters from normal at baseline to abnormal at the final reading. The final ECG for each patient was defined as the last ECG recorded during or within 1 day after the period of double-blind therapy. There were no significant differences in any overall comparison between the sertraline and placebo groups, except for sinus arrhythmia, which was more common in the placebo group. Amitriptyline, compared with sertraline and placebo, significantly increased the heart rate and shortened the RR and QT intervals (p < 0.001). In addition, the incidence of conversion to sinus tachycardia was significantly greater in the amitriptyline group than in the placebo group. Except for conversions in rhythms (mainly from conversions in the sertraline and placebo groups to sinus bradycardia and in the amitriptyline group to sinus tachycardia), the incidence of conversions for all other ECG parameters and for all treatment groups was low and without clinical significance. ECG findings in the elderly were essentially like those noted in nonelderly patients. The results of these analyses show that sertraline has no significant effect on the clinical ECG.
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References
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd ed., American Psychiatric Association, Washington, DC, 1980
Baldessarini RJ. Drugs and the treatment of psychiatric disorders. In Gilman et al. (Eds). The Pharmacological Basis of Therapeutics, pp. 418–430, 6th Edition, Macmillan, New York, 1980
Breslow NE, Day NE. Statistical methods in cancer research, vol. 1: The analysis of case-control studies. International Agency for Research on Cancer, Lyon, 1980
Giardina E-GV. Tricyclic antidepressants in the 1980s: the cardiovascular effects of imipramine. Cardiovascular Reviews and Reports 8: 21–25, 1987
Halper JP, Mann JJ. Cardiovascular effects of antidepressant medications. British Journal of Psychiatry 153: 87–98, 1988
Lehmann EL. Nonparametrics: statistical methods based on ranks, pp. 81–95, Holden Day, San Francisco, 1975
Leonard BE. Pharmacological effects of serotonin reuptake inhibitors. Journal of Clinical Psychiatry 49(Suppl.): 12–17, 1988
Mantel N. Chi square tests with one degree of freedom: extensions of the Mantel-Haenszel procedure. Journal of the American Statistical Association 58: 690–700, 1963
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Fisch, C., Knoebel, S.B. Electrocardiographic Findings in Sertraline Depression Trials. Drug Invest 4, 305–312 (1992). https://doi.org/10.1007/BF03259409
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DOI: https://doi.org/10.1007/BF03259409