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A Case Study of the Utility of the HapMap Database for Pharmacogenomic Haplotype Analysis in the Taiwanese Population

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Abstract

Background: Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to determine the contribution of genes to drug efficacy. The goal of this work was to evaluate the feasibility of using SNP information of the Han Chinese in Beijing (CHB) population from the HapMap database for clinical association studies in the Taiwanese (TWN) population.

Methods: We compared the HapMap populations with our TWN study population with regard to allele frequencies for common SNPs in two candidate genes for antidepressant treatment response to determine the applicability of the HapMap CHB data for SNP selection in the TWN population.

Results and conclusion: Our preliminary results suggest that there was no significant difference, in terms of allele and haplotype frequencies, between the CHB population of the HapMap database and the TWN population collected by Vita Genomics Inc. Therefore, it is possible to use the CHB population of the HapMap database for SNP selection in association studies for the TWN population. Using haplotype analysis, we generated a panel of SNPs that may be strongly relevant to antidepressant response in this population.

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Acknowledgments

The authors extend their sincere appreciation to Vita Genomics Inc. for funding the research. The authors have no conflicts of interest that are directly relevant to the content of this study.

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Authors and Affiliations

  1. Vita Genomics Inc., Taipei, Taiwan

    Eugene Lin, Yuchi Hwang & Chi-Meng Tzeng

  2. GeneCore BioTechnologies Co. Ltd, Shanghai, China

    Chi-Meng Tzeng

Authors
  1. Eugene Lin
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  2. Yuchi Hwang
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  3. Chi-Meng Tzeng
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Correspondence to Eugene Lin.

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Lin, E., Hwang, Y. & Tzeng, CM. A Case Study of the Utility of the HapMap Database for Pharmacogenomic Haplotype Analysis in the Taiwanese Population. Mol Diag Ther 10, 367–370 (2006). https://doi.org/10.1007/BF03256213

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  • DOI: https://doi.org/10.1007/BF03256213

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