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Proteomic analysis of hepatotoxicity induced by titanium nanoparticles in mouse liver

  • Biochemistry
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Abstract

Differentially expressed proteins in mouse liver caused by toxicity of titanium nanoparticles (TiO2 NPs) were screened. More than 1,400 protein spots in mouse liver were detected by twodimensional gel electrophoresis, and 15 proteins that showed greater than 2-fold expressional changes in response to TiO2 NPs were identified by liquid chromatography-tandem mass spectrometry. Of these, 12 proteins were down-regulated and 3 proteins were up-regulated upon treatment with TiO2 NPs. The 15 differentially expressed proteins could be used for detection of inflammation, apoptosis, and antioxidative reaction for treatment of acute hepatic damage by TiO2 NPs.

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Authors and Affiliations

  1. Department of Medical Biotechnology, SoonChunHyang University, Asan, Chungnam, 336-600, Republic of Korea

    Yu-Mi Jeon, Seul-Ki Park & Mi-Young Lee

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  1. Yu-Mi Jeon
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  2. Seul-Ki Park
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Correspondence to Mi-Young Lee.

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Jeon, YM., Park, SK. & Lee, MY. Proteomic analysis of hepatotoxicity induced by titanium nanoparticles in mouse liver. J Korean Soc Appl Biol Chem 54, 852–859 (2011). https://doi.org/10.1007/BF03253172

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  • DOI: https://doi.org/10.1007/BF03253172

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